[1]徐 磊,李 骥,梁志强,等.知葛通脉颗粒治疗糖尿病周围神经病变临床研究*[J].陕西中医,2019,(8):1049-1052.
　XU Lei,LI Ji,LIANG Zhiqiang,et al.Clinical efficacy of Zhige Tongmai granules for treating diabetic peripheral neuropathy[J].,2019,(8):1049-1052.
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知葛通脉颗粒治疗糖尿病周围神经病变临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1049-1052
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Clinical efficacy of Zhige Tongmai granules for treating diabetic peripheral neuropathy
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.08.017
作者:
徐 磊; 李 骥; 梁志强; 曹烨民 △
上海中医药大学附属上海市中西医结合医院脉管病科（上海 200082）
Author(s):
XU Lei; LI Ji; LIANG Zhiqiang; et al.
Department of Vascular Diseases, Shanghai TCM Integrated Hospital Shanghai University of Traditional Chinese Medicine （Shanghai 200082）
关键词:
糖尿病周围神经病变; 痹证; 知葛通脉颗粒; 脾肾两虚; 临床症状评分; TCSS评分
Keywords:
Key words Diabetic peripheral neuropathy; Arthromyodynia; Zhige Tongmai granules; Spleen and kidney deficiency; Clinical symptom score; TCSS score
分类号:
R587.2
文献标志码:
A
摘要:
摘 要 目的：观察知葛通脉颗粒对糖尿病周围神经病变的疗效。方法：选取120例糖尿病周围神经病变的患者作为研究对象。将患者按随机数字表法分为治疗组（口服知葛通脉颗粒）和对照组（口服甲钴胺片）各60例。两组均治疗3个月，比较两组治疗前、后临床症状评分、TCSS评分、神经传导速度等指标的差异。结果:治疗组临床症状评分总有效率为85.00%，优于对照组的58.30%（P＜0.01）。治疗组TCSS评分较对照组降低更显著(P＜0.05)。治疗后两组患者神经传导速度比治疗前有明显的改善（P＜0.05），但是治疗组改善更明显（P＜0.05）。结论：知葛通脉颗粒治疗糖尿病周围神经病变有良好的疗效。
Abstract:
Abstract Objective：To observe the effect of Zhige Tongmai granules for diabetic peripheral neuropathy (DPN).Methods：The 120 patients with diabetic peripheral neuropathy were divided into treatment group (n=60,oral Zhige Tongmai particles) and control group (n=60,oral mecobalamin tablets) according to the random number table method. Both groups were treated for 3 months,the clinical symptom score,TCSS score,nerve conduction velocity and other indicators were compared between two groups. Results：The total effective rate of clinical symptom scores in the treatment group was 85.00%,which was better than that in the control group(58.30%) (P＜0.01)；The TCSS score of the treatment group was significantly lower than that of the control group(P＜0.05)；After treatment,the nerve conduction velocity in the treatment group was more higher than that in tne control group (P＜0.05).Conclusion：Zhige Tongmai granule has good curative effect on diabetic peripheral neuropathy.

参考文献/References:

[1] 方朝晖,吴以岭,赵进东. 糖尿病周围神经病变中医临床诊疗指南：2016年版[J]. 中医杂志,2017,58(7):625-630.
[2] 中华医学会内分泌学分会. 中国成人2型糖尿病预防的专家共识[J]. 中华内分泌代谢杂志,2014,30(4):277-283.
[3] 国家食品药品监督管理总局.中药新药临床研究指导原则[M].北京：中国医药科技出版社,2002:361-364.
[4] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南：2013年版 [J].中华糖尿病杂志,2014,6(7):469-470.
[5] 吉杏媛,李新华,程 萍,等. 糖尿病周围神经病变中医诊治研究进展[J]. 实用中医药杂志,2016,32(9):943-945.
[6] 陈威妮,刘志龙,段素静,等. 当归四逆汤对糖尿病周围神经病变患者震动感觉阈值的影响[J]. 陕西中医,2016,37(6):660-661.
[7] 许延林.前列地尔注射液治疗糖尿病周围神经病变38例疗效观察[J].陕西医学杂志,2016,45(9):1233-1234.
[8] Lu J,Luo Y,Wang J,et al. Association of type 2 diabetes susceptibility loci with peripheral nerve function in a Chinese population with diabetes[J]. J Diabetes Investig，2016，8(1):115-120.
[9] 王淑珍,刘连友. 糖尿病周围神经病变的诊治进展[J]. 现代诊断与治疗,2016,27(19):3738-3740.
[10] 杨秀颖,张 莉,陈 熙,等. 2 型糖尿病周围神经病变机制研究进展[J]. 中国药理学通报,2016,32(5)：598-602.
[11] 范 佳,省格丽. 糖尿病周围神经病变中医研究进展[J]. 新疆中医药,2016,34(4):144-147.
[12] 李 颖,李 刚,冯 波. 糖尿病周围神经病变的诊治进展[J]. 中国糖尿病杂志,2013,21(9)：769-772.
[13] 王淑珍,刘连有.糖尿病周围神经病变中医治疗进展[J]. 中国临床医生杂志,2016,44(3):30-32.
[14] 李黔云,杜义斌,段艳蕊. 中西医结合治疗糖尿病周围神经病变54例临床观察[J]. 河北中医,2015,37(5):705-707.
[15] 王文艳. 益气活血法治疗气虚血瘀型糖尿病周围神经病变临床研究[J]. 中医学报,2015,30(11):1586-1587.
[16] 王瑞阳,马文杰. 糖尿病周围神经病变的中西医研究进展[J]. 中医临床研究,2016,8(3)：89-90.
[17] 冬梅巴提布尔. 从“痰瘀”论治糖尿病周围神经病变[J]. 光明中医,2016,31(14):2012-2014.
[18] 潘廷梅,王 旭. 丹参葛根配方颗粒治疗糖尿病周围神经病变临床观察[J]. 四川中医,2015,33(6):70-71.
[19] 白 清. 黄芪桂枝五物汤对糖尿病周围神经病变的疗效及神经传导速度的影响[J]. 中成药,2015,37(5):962-964.
[20] 刘思洋,赵兴冉,顾 健,等. 葛根黄连有效组分配伍抗2型糖尿病机制初步研究[J]. 中药材,2016,39(3):641-644.
[21] 陈笑南,张国伟. 知母抗糖尿病的研究进展[J]. 医学研究与教育,2014,31(5)：85-88.
[22] 蒋 学. 白僵蚕活性成分分离纯化及其药理作用的研究[D]. 浙江大学,2013.
[23] 赵红霞,汪文来,贾海骅,等. 单味中药防治糖尿病的现代研究探讨[J]. 中国医药导刊,2013,15(10)：1692-1694.
[24] 栗 明,杨珊娜,杨 可,等. 中药治疗糖尿病性周围神经病变的药理学研究进展[J]. 中国临床保健杂志,2016,19(1):107-110.
[25] 饶潇潇,姚广涛,文小平. 中药干预糖尿病周围神经病变作用机制研究进展[J]. 中国中医药信息杂志,2017,24(4):130-133.

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备注/Memo

备注/Memo:
上海市虹口区卫生和计划生育委员会医学科研课题 (虹卫1704-15)
更新日期/Last Update: 2019-08-15