[1]陈利民,牛聪慧,陆一兰.柴胡左金汤辨证治疗胃食管反流病疗效研究[J].陕西中医,2019,(8):1091-1093.
　CHEN Limin,NIU Conghui,LU Yilan..Clinical effect on patients with gastroesophageal reflux disease treated with Chaihu Zuojin decoction[J].,2019,(8):1091-1093.
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柴胡左金汤辨证治疗胃食管反流病疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1091-1093
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Clinical effect on patients with gastroesophageal reflux disease treated with Chaihu Zuojin decoction
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.08.029
作者:
陈利民; 牛聪慧; 陆一兰
湖北省麻城市人民医院 （麻城 438300）
Author(s):
CHEN Limin; NIU Conghui; LU Yilan.
People’s Hospital of Macheng City in Hubei Province (Macheng 438300）
关键词:
胃食管反流病;  柴胡左金汤; 辨证施治; 雷贝拉唑钠肠溶片; 疗效
Keywords:
Key words Gastroesophageal reflux disease; Chaihu Zuojin decoction; Treatment based on syndrome differentiation; Rabeprazole sodium enteric-coated table; Effect
分类号:
R573
文献标志码:
A
摘要:
摘 要 目的：评价柴胡左金汤辨证治疗胃食管反流病的临床疗效。方法：收集胃食管反流病患者60例随机分为治疗组、对照组，治疗组采用柴胡左金汤辨证化裁治疗，对照组采用雷贝拉唑钠肠溶片口服治疗。两组治疗疗程均为8周，比较两组治疗前后症状积分变化以及停药2个月后复发率。结果：两组治疗前反酸、烧心、嗳气、胃脘胀满症状积分无统计学差异（P＞0.05）。治疗后两组上述症状积分均有不同程度下降（P＜0.05），但治疗组较对照组在反酸、烧心、胃脘胀满改善更明显（P＜0.05）。治疗组总有效率96.67%，高于对照组80.00%，差异有统计学意义（P＜0.01）。在随访期结束治疗组有4例复发，复发率13.33%；对照组有12例复发，复发率为40.00%，两组复发率比较，差异有统计学意义（P＜0.05）。结论：中药柴胡左金汤辨证治疗胃食管反流病疗效确切，可有效改善反酸、烧心、嗳气、胃脘胀满症状，改善反流现象。
Abstract:
Abstract Objective :To investigate the clinical effect of Chaihu Zuojin decoction in the treatment of gastroesophageal reflux disease(GERD).Methods：60 cases of GERD collected according to the diagnostic criteria and inclusion criteria，were randomly divided into two groups. The treatment group(n=30) was treated with Chaihu Zuojin decoction，and the control group(n=30) was treated with rabeprazole sodium enteric-coated tablet(20mg/d). The course of treatment was 8 weeks.The changes of symptom score and recurrence rate after 2 months of with drawal were compared between the two groups before and after treatment. Results：There was no significant difference in symptom scores of acid reflux，heartburn，belching and epigastric fullness before treatment between the two groups（P＜0.05）.After treatment，the scores of the above symptoms in both groups decreased in varying degrees（P＜0.05）.The improvement of acid reflux，heart burn and epigastric fullness in the treatment group was more obvious than that in the control group（P＜0.05）.The total effective rate of the treatment group was 96.67%，higher than that of the control group (80.00%，P＜0.01). At the end of the follow-up period，there were 4 recurrences in the treatment group (13.33%) and 12 recurrences in the control group (40.00%). There was a significant difference in the recurrence rate between the two groups(P＜0.05).Conclusion：Chinese medicine Chaihu Zuojin decoction has definite curative effect on gastroesophageal reflux disease. It can effectively improve the symptoms of acid reflux，heartburn，belching and epigastric fullness，and improve reflux phenomenon. 

参考文献/References:

[1] 李军祥,陈 誩,李 岩.胃食管反流病中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2018,26(3):221-226，232.
[2] 庞鹏宇,王沁易.曾升海教授从肝论治胃食管反流病经验[J].陕西中医,2016,37(3):344-345.
[3] 沈 晨，张声生，赵鲁卿，等.228例胃食管反流病患者中医证候及症状分布特点[J].中国中西医结合消化杂志,2015,23(9):622-625. 
[4] 王万卷,宗湘裕,杜长海,等.反流性食管炎中医证素分布特点的临床研究[J].河北中医,2014,36(7):996-997.
[5] 陈旻湖,侯晓华,肖英莲，等.2014年中国胃食管反流病专家共识意见[J].胃肠病学,2015,20(3):155-168.
[6] 王国建,陈 建.质子泵抑制剂过度使用常见不良事件的循证评价[J].中国医院药学杂志,2013，33(11):919-922.
[7] 李培润,王小涛,叶秀红.左金抑反汤治疗反流性食管炎32例[J].陕西中医,2012,33(1):19-20.
[8] 耿昌海，姚 轶，洪 兵.旋覆代赭汤加味治疗肝胃郁热型胃食管反流病疗效及其机制[J].辽宁中医药大学学报，2016,18(9):177-180.
[9] 李京伟，陈玉琴，吴海滨，等.开郁降逆汤加减治疗肝胃郁热型胃食管反流病30例[J].中国民族民间医药，2018,27(9):70-73.
[10] 李 岩,陈治水,危北海.胃食管反流病中西医结合诊疗共识意见(2010)[J].中国中西医结合杂志,2011，31(11):1550-1553.
[11] 国家食品药品监督管理总局.中药新药临床研究指导原则(试行) [M].北京:中国医药科技出版社,2002: 124-129.
[12] 中华中医药学会脾胃病分会.胃食管反流病中医诊疗共识意见(2009,深圳)[J].中医杂志,2010，51(9):844-847.
[13] 王 帅,包永睿,孟宪生,等.柴胡皂苷对无水乙醇致胃黏膜损伤的保护作用[J].中国实验方剂学杂志,2013,19(8):191-194.
[14] 刘小河,马艳红，傅延龄.黄芩汤对反流性食管炎模型大鼠氧化应激和胃肠激素的影响[J].时珍国医国药，2011,22(7):1778-1780.
[15] 杨 芳,柳玉强,高庆剑.抗焦虑药联合质子泵抑制剂治疗胃食管反流病80例[J].陕西医学杂志,2015,44(4):487-488.

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更新日期/Last Update: 2019-08-15