[1]王 晶,方柯南,孙 洁.防己黄芪汤治疗小儿肾病综合征疗效及对患儿肾功能、凝血系统的影响*[J].陕西中医,2019,(9):1183-1186.
　WANG Jing,FANG Kenan,SUN Jie..Clinical efficacy of Fangji Huangqi decoction and effect on renal function and coagulation system in treating pediatric nephrotic syndrome[J].,2019,(9):1183-1186.
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防己黄芪汤治疗小儿肾病综合征疗效及对患儿肾功能、凝血系统的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1183-1186
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
Clinical efficacy of Fangji Huangqi decoction and effect on renal function and coagulation system in treating pediatric nephrotic syndrome
文章编号:
DOI:10.3969/j.issn.10007369.2019.09.009
作者:
王 晶; 方柯南; 孙 洁
河南省洛阳市妇女儿童医疗保健中心（洛阳471000）
Author(s):
WANG Jing; FANG Kenan; SUN Jie.
Luoyang Women and Children Medical Care Center in Henan Province（Luoyang 471000）
关键词:
防己黄芪汤; 小儿; 肾病综合征; 临床疗效研究; 肾功能; 凝血系统
Keywords:
Key words Fangji huangqi decoction; Children; Nephrotic syndrome; Study of clinical efficacy; Renal function; Blood coagulation system
分类号:
R277.5
文献标志码:
A
摘要:
摘 要 目的：探讨防己黄芪汤加减治疗小儿肾病综合征（PNS）的临床疗效及对肾功能、凝血系统的影响。方法：215例PNS患儿按随机数字表法分为治疗组108例、对照组107例。在给予常规西医对症处理及支持疗法的基础上，对照组予以强的松，治疗组在此基础上加用防己黄芪汤加减给药，比较两组临床疗效、24 h尿蛋白量、ALB、TC、肾功能指标与凝血指标。结果：治疗组总有效率高于对照组（P＜0.05），24 h尿蛋白量、TC水平低于对照组（P＜0.05），ALB水平高于对照组（P＜0.05），SCr、BUN水平低于对照组（P＜0.05），Ccr水平高于对照组（P＜0.05），PT、APTT水平高于对照组（P＜0.05）；两组不良反应比较无统计学意义（P＞0.05）。结论：防己黄芪汤加减治疗PNS疗效安全有效，能显著改善患儿高凝血状态，抑制肾小球毛细血管内微血栓的形成，改善肾功能，延缓肾小球硬化的进展。
Abstract:
Abstract Objective:To investigate the clinical efficacy of Fangji Huangqi decoction in the treatment of pediatric nephrotic syndrome (PNS) and its effect on renal function and coagulation system.Methods:215 cases of PNS children were admitted and treated in our hospital divided into treatment group 108 cases and control group 107 cases by random number table.On the basis of conventional western medicine symptomatic treatment and supportive therapy,the control group was given prednisone,and the treatment group was given Fangji Huangqi decoction plus or minus on this basis,and the clinical efficacy,24hour urine protein volume ALB,TC,renal function indexes and coagulation indexes of the two groups were compared.Results:The total effective rate of the treatment group was higher than that of the control group (P＜0.05).The urine protein content and TC level at 24 h were lower than that of the control group (P＜0.05).The ALB level was higher than that of the control group (P＜0.05).The SCr and BUN levels were lower than that of the control group (P＜0.05).The Ccr level was higher than that of the control group (P＜0.05).The PT and APTT levels were higher than those of the control group (P＜0.05).There was no statistical significance in adverse reactions between the two groups (P＞0.05).Conclusion:Fangji Huangqi decoction is safe and effective in the treatment of PNS,which can significantly improve the hypercoagulation status of children,inhibit the formation of microthrombus in glomerular capillae,improve renal function,and delay the progress of glomerular sclerosis.

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备注/Memo

备注/Memo:
*河南省洛阳市科技局资助项目（2014KYB059）
更新日期/Last Update: 2019-09-24