[1]成 洁,王 颖△,吉健华,等.骨疏康胶囊治疗肾阳虚型骨质疏松症疗效及对患者骨代谢影响*[J].陕西中医,2019,(9):1232-1234,1250.
　CHENG Jie,WANG Ying,JI Jianhua,et al.Effect of Gushukang capsule on the treatment of Shenyangxu osteoporosis and effect on bone metabolism[J].,2019,(9):1232-1234,1250.
点击复制

骨疏康胶囊治疗肾阳虚型骨质疏松症疗效及对患者骨代谢影响*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1232-1234,1250
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
Effect of Gushukang capsule on the treatment of Shenyangxu osteoporosis and effect on bone metabolism
文章编号:
DOI:10.3969/j.issn.10007369.2019.09.023
作者:
成 洁1; 王 颖1△; 吉健华1; 宋欣丽1; 黄英莉3
1.西安市第五医院风湿免疫科（西安 710082）；2.西安市中心医院老年干部科（西安 710003）
Author(s):
CHENG Jie; WANG Ying; JI Jianhua; et al.
Xi 'an Fifth Hospital(Xi’an710082)
关键词:
骨疏康胶囊; 肾阳虚型; 骨质疏松症; 疗效; 骨代谢; 总Ⅰ型胶原氨基端延长肽
Keywords:
Key words Gushukang capsule; Shenyangxu; Osteoporosis; Efficacy; Bone metabolism; Total type I procollagen amino terminal elongation peptide
分类号:
R68
文献标志码:
A
摘要:
摘 要 目的：研究了骨疏康胶囊辅助对肾阳虚型骨质疏松症（OP）患者的治疗效果及对骨代谢的影响。方法：纳入OP患者160例，按照随机数字表法分为常规组和骨疏康组，各80例。常规组患者服用钙尔奇D片，1片/次，2次/d。骨疏康组在常规组的基础上服用骨疏康胶囊，4粒/次，2次/d。分别于治疗前后对两组患者的临床症状改善评分、骨密度、血清磷、TPINP、血清钙以及血碱性磷酸酶水平进行比较，比较两组患者的治疗有效率。结果：治疗后骨疏康组腰膝酸痛、乏力、大便溏薄、畏寒以及夜尿频繁评分均明显低于常规组（P＜0.05）。骨疏康组的治疗有效率83.75%明显高于常规组53.75%（P＜0.05）。治疗后常规组腰椎L24和Ward区骨密度明显低于骨疏康组（P＜0.05）。治疗后骨疏康组和常规组TPINP、血碱性磷酸酶水平均明显增加（P＜0.05），其中骨疏康组变化更大（P＜0.05）。治疗后骨疏康组血清磷、血清钙水平与常规组相比，差异无统计学意义（P＞0.05）。结论：骨疏康胶囊辅助治疗肾阳虚型OP，能够明显改善患者临床症状，提高治疗有效率，并通过对骨代谢紊乱的调节促进骨形成，进而有助于机体骨密度的增加，起到对OP的治疗作用。
Abstract:
Abstract Objective:To study the effect of Gushukang capsule on the treatment of Shenyangxu osteoporosis and it effect on bone metabolism. Methods: 160 patients with OP were enrolled. According to the random number table method, they were divided into the conventional group and the Gushukang group, 80 cases each.The patients in the conventional group were taking calcium D tablets, 1 piece/time, 2 times/d.The Gushukang group took the Gushukang capsule on the basis of the conventional group, 4 capsules / time,2 times / d. The clinical symptom improvement score, bone mineral density, serum phosphorus, TPINP, serum calcium and blood alkaline phosphatase levels were compared between the two groups before and after treatment, and the treatment efficiency of the two groups was compared. Results:After treatment, the waist and knee pain, fatigue, loose stools, chills and nocturia frequent scores in the Gushukang group were significantly lower than the conventional group (P＜0.05). The treatment efficiency of the Gushukang group（83.75%）was significantly higher than that of the conventional group （53.75%）(P＜0.05). After treatment, the bone density of lumbar vertebrae L24 and ward area in the conventional group was significantly lower than that in the Gushukang group (P＜0.05). After treatment, the levels of TPINP and blood alkaline phosphatase in the Gushukang group and the conventional group were significantly increased (P＜0.05), and the changes in the Gushukang group were greater (P＜0.05). After treatment, the serum phosphorus and serum calcium levels in the Gushukang group were not significantly different from those in the conventional group (P＞0.05). Conclusion:Gushukang capsule treat Shenyangxu osteoporosis, can significantly improve the clinical symptoms of patients, improve the efficiency of treatment, and promote bone formation through the regulation of bone metabolism disorder, which will help the increase of bone density in the body and the therapeutic effect of OP.

参考文献/References:

[1] 童迪夷,梁兴伦,赵 雁.适合中国国情的中老年骨质疏松症防治六原则[J] .中国全科医学,2017, 20(12):14031409.
[2] 曾昭洋,胡文斌,魏学玲,等.中老年人群原发性骨质疏松中医体质及辨证分型分布[J] . 中国老年学杂志,2018,38(2):435438.
[3] 《中国老年骨质疏松症诊疗指南》(2018)工作组,中国老年学和老年医学学会骨质疏松分会,马远征,等.中国老年骨质疏松症诊疗指南(2018)[J] .中国骨质疏松杂志,2018,24(12):15411567.
[4] 中国老年学学会骨质疏松委员会“骨质疏松诊断标准”学科组.中国人骨质疏松症建议诊断标准(第二稿)[J] .中国骨质疏松杂志,2000,6(1):13.
[5] 吴鑫宇,朱洁宜,李 冀.骨质疏松症的中医临床方药研究进展[J] .中医药学报,2013,41(4):128130.
[6] 刘卫祥,龚雨依.补肾健脾活血方配合阿仑膦酸钠片治疗骨质疏松症疗效研究[J] .陕西中医, 2018, 39(10):108110+168.
[7] 郭小兰,董 博,姚 洁.益气补肾法治疗原发性骨质疏松症疗效观察[J] .陕西中医,2017, 38(10):14341435.
[8] 李建伟,刘飞奇,李国华,等.慢病管理模式对骨质疏松症的影响[J] .中国医疗设备, 2017,14(32)228229.
[9] 李学朋,朱立国.骨疏康胶囊对去卵巢大鼠骨小梁的影响[J] .中医正骨,2015,27(12):1215.
[10] 黄 莉,李 悦,邱建利,等.骨疏康治疗原发性骨质疏松症随机对照临床研究Meta分析[J] . 辽宁中医药大学学报,2016,18(4):8588.
[11] 白津硕,关雪峰.论中成药治疗原发性骨质疏松症临床应用[J] .辽宁中医药大学学报, 2017,19(8):99103.
[12] 李永贤,张顺聪,梁 德,等.补肾中药通过调控Notch1蛋白的表达治疗大鼠骨质疏松性骨折的作用研究[J] .中国骨质疏松杂志,2017,23(11):14251430.
[13] 邓 昶,周明旺,付志斌,等.骨质疏松症的中医病因病机及其治疗进展[J] .中国骨质疏松杂志,2017,23(8):11051111.
[14] 郑煜晖,吴世强,庄华峰,等.老年骨质疏松患者骨代谢指标、骨密度与骨质疏松性骨折的相关性[J] .中国老年学杂志,2017,37(23):59205922.
[15] 申 浩,赵海燕,魏 戌,等.骨代谢标志物在骨质疏松症中医药诊疗中的应用研究进展[J] .中国骨质疏松杂志,2017,23(10):131135.

备注/Memo

备注/Memo:
*陕西省社会发展攻关项目(2017SF248)
更新日期/Last Update: 2019-09-24