[1]吴昭利,李成军,李仁廷,等.通麻汤联合穴位注射治疗结直肠癌奥沙利铂化疗相关外周神经毒性疗效研究*[J].陕西中医,2019,(9):1247-1250.
　WU Zhaoli,LI Chengjun,LI Renting,et al.Clinical study on Tongma decoction combined with acupoint injection in the treatment of peripheral neurotoxicity related to oxaliplatin chemotherapy for colorectal cancer[J].,2019,(9):1247-1250.
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通麻汤联合穴位注射治疗结直肠癌奥沙利铂化疗相关外周神经毒性疗效研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1247-1250
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
Clinical study on Tongma decoction combined with acupoint injection in the treatment of peripheral neurotoxicity related to oxaliplatin chemotherapy for colorectal cancer
文章编号:
DOI:10.3969/j.issn.10007369.2019.09.028
作者:
吴昭利; 李成军; 李仁廷; 杨得振; 千维娜△
陕西中医药大学附属医院（咸阳 712000）
Author(s):
WU Zhaoli; LI Chengjun; LI Renting; et al.
Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine(Xianyang 710038)
关键词:
通麻汤; 穴位注射; 外周神经毒性; 奥沙利铂; 结直肠癌; 化疗; 临床观察
Keywords:
Key words Tongma decoction; Acupoint injection; Peripheral neurotoxicity; Oxaliplatin; Colorectal cancer; Chemotherapy; Clinical observation
分类号:
R73
文献标志码:
A
摘要:
摘 要 目的：观察通麻汤联合穴位注射治疗结直肠癌奥沙利铂化疗相关外周神经毒性（OIPN）的临床观察，以期为临床治疗OIPN提供有效治法。方法：将113例OIPN患者分为治疗组57例和对照组56例，对照组给与甲钴胺分散片口服，治疗组在对照组基础上给予通麻汤联合穴位注射，治疗28 d，观察两组周围神经毒性分级、奥沙利铂levitll专用感觉神经毒性分级、中医症候量表评分、FACEC生命质量、血清神经生长因子水平（NGF）等。结果：两组治疗后外周神经毒性反应分级治疗组0级13例，1级21例；对照组0级5例，1级16例；两组治疗后对比具有统计学意义（P＜0.05）。奥沙利铂levitll专用感觉神经毒性分级，两组治疗后对比具有统计学意义（P＜0.05）。两组治疗后 NGF、FACEC生命质量、中医证候量表评分对比具有统计学意义（P＜0.05）。结论：通麻汤联合穴位注射治疗OIPN具有较好的效果。
Abstract:
Abstract Objective:To observe the clinical observation of Tongma decoction combined with acupoint injection in the treatment of oxaliplatinrelated peripheral neurotoxicity (OIPN) in colorectal cancer,in order to provide effective treatment for OIPN.Methods:113 patients with OIPN were divided into treatment group (57 cases) and control group (56 cases).The control group was given mecobalamin dispersible tablets orally.The treatment group was given Tongma decoction combined with acupoint injection on the basis of the control group for 28 days.Peripheral neurotoxicity grading,special sensory neurotoxicity grading of oxaliplatin levitll,TCM symptom scale score,FACEC quality of life and serum nerve growth were observed.Factor level (NGF) and so on.Results:After treatment,there were 13 patients in the treatment group,21 in the first grade,5 in the control group and 16 in the first grade.There was significant difference between the two groups after treatment (P＜0.05).There was significant difference between the two groups after treatment (P＜0.05).There was also significant difference between the two groups after treatment in the special sensory neurotoxicity classification of oxaliplatin levitll (P＜0.05).The quality life of NGF,FACEC and the quantity of TCM syndromes in the the score of the table had statistical significance (P＜0.05).Conclusion:Tongma decoction combined with acupoint injection has good curative effect on OIPN and is worthy of clinical application.

参考文献/References:

[1] 周海辉,张海霞,葛卫红.甲钴胺联合维生素B6预防奥沙利铂所致神经毒性疗效观察[J] .中国药师,2019,22(1):8487.
[2] 杨 正,石 年.奥沙利铂神经毒作用模式及防治研究进展[J] .毒理学杂志,2015,29(2):144147.
[3] 王建楠,贾 尧,顾群浩.祛麻煎外用治疗奥沙利铂相关外周神经毒性的临床观察[J] .中华中医药杂志,2014,30(5):13471349.
[4] 中国抗癌协会.新编常见恶性肿瘤诊治规范[M] .北京:中国协和医科大学,1998：2629.
[5] 刘 青,贡 涛,汤秀红,等.温经通络法防治奥沙利铂致外周神经毒性的临床研究[J] .中医药信息,2019,36(1):3741.
[6] 瞿 幸.中医皮肤性病学[M] .北京:中国中医药出版社,2009:158173.
[7] 国家中医药管理局.中药新药临床研究指导原则[M] .北京:中国医药科技出版社,2002,26353.
[8] 曹 玲,于 丹.艾叶的化学成分、药理作用及产品开发研究进展[J] .药物评价研究,2018,41(5):918921.
[9] 邵杰敏,连玉菲,阎乐浩.不同产地黄芪中的黄芪总皂苷含量对比分析 [J] .陕西中医,2018,39(2):268271.
[10] 徐 锋,王德健.桂枝挥发油的药理作用研究进展[J] .中华中医药杂志,2016,31(11):46534655.
[11] 王 莹,刘永芳,熊志强,等.名老中医付义中药细辛运用经验总结[J] .时珍国医国药,2018,29(10):25072509.
[12] 郭梦圆.穴位贴敷联合益气活血方对奥沙利铂化疗所致神经毒性的影响[J] .湖南中医杂志,2015,31(8):7881.
[13] 李宝平,张海亮,王新团.奥沙利铂及卡培他滨辅助化疗结直肠癌41例疗效观察 [J] .陕西医学杂志,2017:46(9):12821286.
[14] 文 亢,李 俊.参麦注射液联合FOLFOX方案治疗结直肠癌的临床研究[J] .陕西中医,2015,36(1):36.

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备注/Memo

备注/Memo:
*陕西省卫生和计划生育委员会资助项目（2018E018）
更新日期/Last Update: 2019-09-24