[1]王 菲,蔡 峥△.柴胡加龙骨牡蛎汤加减治疗老年原发性高血压疗效及对患者内皮损伤标志物水平和血压水平影响[J].陕西中医,2019,(9):1261-1264.
　WANG Fei,CAI Zheng..Effect of Chaihu Jia Longgumuli decoction on the level of endothelial injury markers and blood pressure in elderly patients with essential hypertension[J].,2019,(9):1261-1264.
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柴胡加龙骨牡蛎汤加减治疗老年原发性高血压疗效及对患者内皮损伤标志物水平和血压水平影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1261-1264
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
Effect of Chaihu Jia Longgumuli decoction on the level of endothelial injury markers and blood pressure in elderly patients with essential hypertension
文章编号:
DOI:10.3969/j.issn.10007369.2019.09.032
作者:
王 菲; 蔡 峥△
上海中医药大学附属曙光医院（上海 200023）
Author(s):
WANG Fei; CAI Zheng.
Shuguang Hospital, Shanghai University of Traditional Chinese Medicine（Shanghai 200023）
关键词:
柴胡加龙骨牡蛎汤; 原发性高血压; 老年患者; 内皮损伤; 血流动力学; 血压水平; 临床症状
Keywords:
Key words Chaihu Jia Longgumuli decoction; Essential hypertension; Elderly patients; Endothelial injury; Hemodynamics; Blood pressure level; Clinical symptoms
分类号:
R544.1
文献标志码:
A
摘要:
摘 要 目的：分析柴胡加龙骨牡蛎汤加减治疗原发性高血压对老年患者内皮损伤标志物水平和血压水平影响。方法：152例原发性高血压患者为对象，以治疗措施的不同为依据予分组。对照组76例采用口服卡托普利片和苯磺酸氨氯地平片治疗，观察组76例在对照组基础上联合柴胡加龙骨牡蛎汤加减治疗，分析两组临床疗效。结果：观察组治疗后中医症候积分（12.74±3.11）分，低于对照组（17.65±4.63）分（P＜0.05)。观察组治疗后血压水平低于对照组（P＜0.05)。观察组治疗后一氧化氮水平高于对照组，血管性假血友病因子、内皮素1、细胞间黏附分子1水平低于对照组（P＜0.05)。观察组治疗后椎动脉收缩期流速峰值、舒张末期流速水平高于对照组，血管搏动指数（PI）水平低于对照组（P＜0.05)。结论：柴胡加龙骨牡蛎汤加减治疗原发性高血压可改善患者临床症状，减轻内皮损伤，调节异常的血流动力学。
Abstract:
Abstract Objective：To analyze the effect of Chaihu Jia Longgumuli decoction on endothelial injury markers and blood pressure in elderly patients with essential hypertension. Methods：The data of 152 patients with essential hypertension admitted were analyzed and divided into two groups according to different treatment methods. The control group was treated with captopril tablets and amlodipine benzenesulfonic acid tablets, the observation group was treated with Chaihu Jia Longgumuli decoction on the basis of the control group, and the clinical efficacy of the two groups was analyzed. Results：The scores of TCM symptoms in the observation group were （12.74±3.11）,which were lower than those of the control group(17.65±4.63)（P＜0.05). The blood pressure in the observation group was lower than that in the control group (P＜0.05).After treatment, the levels of nitric oxide in the observation group were higher than those in the control group, and endothelin1 was the factor of von Willebrand disease. The level of intercellular adhesion molecule1 was lower than that of control group (P＜0.05). The peak systolic velocity , enddiastolic velocity of vertebral artery in the observation group was higher than that in the control group after treatment. The level of pulsatile index was lower than that in control group (P＜0. 05).Conclusion：Treatment of essential hypertension with Chaihu Jia Longgumuli decoction can improve clinical symptoms, alleviate endothelial injury and regulate abnormal hemodynamics.

参考文献/References:

[1] 侯利红,殷艳玲.硝苯地平联合复方罗布麻颗粒治疗原发性高血压疗效研究[J] .陕西医学杂志,2018,47(11):14831486.
[2] 彭书涛,李亚宁. 降压方联合卡托普利治疗原发性高血压疗效观察[J] .陕西中医,2017,38(7):875876.
[3] 刘俊燕,栗 娜.苯磺酸氨氯地平联合赖诺普利氢氯噻嗪与阿托伐他汀治疗重度原发性高血压合并颈动脉粥样硬化的临床观察[J] .中国药房,2017,28(9):12071210.
[4] 汪林琴,穆攀伟,黎丽娴，等.益气化痰活血法对血脂正常的高血压患者血管内皮功能的影响[J] .贵阳中医学院学报,2017,39(2):6468.
[5] 吴欣芳,谢相智,许国磊,等.柴胡加龙骨牡蛎汤治疗原发性高血压病伴焦虑的临床观察[J] .世界中西医结合杂志,2016,11(11):14971499.
[6] 中国高血压防治指南修订委员会.中国高血压防治指南(2010)[J] .中华高血压病杂志,2011,19(8):701743.
[7] 国家中医药管理局.中药新药临床研究指导原则[M] .北京:中国医药科技出版社,2002:7377.
[8] 白起君,黄 捷,周晓亚,等.清眩补肾汤治疗原发性高血压疗效及对患者肾素血管紧张素醛固酮影响[J] .陕西中医,2019,40(3):311314.
[9] 孙 萍,盛家和,许青霞, 等.不同型别幽门螺杆菌感染的高血压患者血清中TNFα、IL6、IL8水平研究[J] .传染病信息,2018,31(2):165167.
[10] 张伟萍.平肝降浊活血利水法治疗原发性高血压临床效果分析[J] .基层医学论坛,2016,20(8):10971098.
[11] 陈 娟.陈美华以滋肾平肝、化痰活血法治疗原发性高血压的临床研究[J] .光明中医,2016,31(2):202205.
[12] 宁小康,王文丽,苗 琦.养血清脑颗粒对原发性高血压眩晕患者血栓前状态及血流动力学的影响[J] .陕西中医,2017,38(7):867869.
[13] 杜龙益,钱林超,苏 杰,等.钱林超疏肝清热利水法治疗原发性高血压病临床经验[J] .江西中医药,2018,49(9):1921.
[14] 周亚福,毛少利,王宇超,等.紫花大叶柴胡根、茎、叶的结构及与药效成分积累关系[J] .中成药,2018,40(5):11291134.
[15] 郑勇凤,王佳婧,傅超美,等.黄芩的化学成分与药理作用研究进展[J] .中成药,2016,38(1):141147.
[16] 邵江娟,李蒙蒙,付金柏,等.牡蛎配伍葛根对自发性高血压(SHR)大鼠降血压作用机制研究[J] .江苏中医药,2017,49(8):7578.
[17] 杨 悦.联合检测血浆血管紧张素Ⅱ、醛固酮、肾素、血浆凝集素样氧化低密度脂蛋白受体1、内皮素1水平对原发性高血压的临床意义[J] .中国卫生检验杂志,2016,26(15):22012203.
[18] 朱雪莲,鲁利民,朱锦萍,等.丹参酮ⅡA磺酸钠注射液对原发性高血压患者血脂水平及内皮功能的影响[J] .现代生物医学进展,2016,16(20):39323935.
[19] 周 蕾,蔡红芳.穴位埋线辅助治疗原发性高血压及对患者血管内皮功能的影响[J] .中国针灸,2018,38(4):349352.
[20] 周 萍,刘秀红,杜亚平,等.银杏叶片联合硝苯地平片对高血压患者血栓前状态相关指标的影响[J] .海南医学院学报,2016,39(5):435437,440.
[21] 蓝 芳,谢丽萍,谢永祥, 等.加味附子理中汤对药物性急性肾损伤患者T淋巴细胞亚群及血管性假血友病因子的影响[J] .临床肾脏病杂志,2017,17(6):336339.
[22] Lopes PM, Kroon J,Hoogenboezem M,et al.Acid sphingomyelinasederived ceramide regulates ICAM1 function during T cell transmigration across brain endothelial cells[J] .J Immunol,2016,196(1):7279.
[23] 曹丽霞,郑延泽,武海军, 等.嘎日迪-13对大鼠脑缺血后不同时相不同脑区ICAM-1、VCAM-1表达的影响[J] .中华中医药学刊,2017,35(12):30093014.

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更新日期/Last Update: 2019-09-24