[1]王 旭,佘明明△.活血生肌汤联合自体骨髓血干细胞移植对糖尿病足创面的修复作用研究[J].陕西中医,2019,(10):1364-1366.
　WANG Xu,SHE Mingming..Study on the repair effect of Huoxue Shengji decoction combined with autologous bone marrow stem cell transplantation on diabetic foot wounds[J].,2019,(10):1364-1366.
点击复制

活血生肌汤联合自体骨髓血干细胞移植对糖尿病足创面的修复作用研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年10期
页码:
1364-1366
栏目:
临床研究
出版日期:
2019-10-05

文章信息/Info

Title:
Study on the repair effect of Huoxue Shengji decoction combined with autologous bone marrow stem cell transplantation on diabetic foot wounds
文章编号:
DOI:10.3969/j.issn.10007369.2019.10.013
作者:
王 旭; 佘明明△
陕西省商洛市中心医院骨科（商洛726000）
Author(s):
WANG Xu; SHE Mingming.
Department of Orthopaedics，Shangluo Central Hospital in Shaanxi Province（Shangluo 726000）
关键词:
糖尿病足; 创面; 修复; 活血生肌汤; 自体骨髓血; 干细胞移植
Keywords:
Key words 〖HT5”SS〗Diabetic foot; Wound; Repairing; Huoxue Shengji decoction; Autologous bone marrow blood; Stem cell transplantation
分类号:
R587.2
文献标志码:
A
摘要:
摘 要 目的：研究活血生肌汤联合自体骨髓血干细胞移植对糖尿病足创面的修复作用。方法：选取74例糖尿病足患者，均行常规内科治疗，分为对照组（采取自体骨髓血干细胞移植）和研究组（采取活血生肌汤联合自体骨髓血干细胞移植治疗），两组各37例。比较两组患者治疗前后血糖水平、患足溃疡面积、下肢神经传导速度和治疗后间歇性跛行、足冷感觉、静息疼及愈合情况等差异。结果：研究组治疗后血糖水平较对照组明显降低（P＜0.05），治疗后间歇性跛行、足冷感觉、静息疼较对照组均明显改善（P＜0.05）。研究组治疗后患足溃疡面积较对照组明显减少，愈合率较对照组明显升高（P＜0.05）。研究组治疗后下肢正中神经传导速度和腓神经传导速度较对照组均明显加快（P＜0.05）。结论：采取活血生肌汤联合自体骨髓血干细胞移植可有效改善糖尿病足患者治疗效果，促进创面愈合，加快血管新生，有助于尽快建立侧支循环，取得良好的临床疗效。
Abstract:
Abstract 〖HT5”SS〗Objective：To study the effect of Huoxue Shengji decoction combined with autologous bone marrow stem cell transplantation on repairing diabetic foot wounds. Methods：74 patients with diabetic foot were divided into control group (treated with autologous bone marrow stem cell transplantation) and research group (treated with Huoxue Shengji decoction combined with autologous bone marrow stem cell transplantation)，37 cases in each group. The blood sugar level，ulcer area，nerve conduction velocity of lower limbs，intermittent claudication，cold sensation of feet，resting pain and healing were compared between the two groups before and after treatment. Results：After treatment，the blood sugar level in the study group was significantly lower than that in the control group (P＜0.05). After treatment，the intermittent claudication，cold sensation of feet and resting pain in the study group were significantly improved compared with those in the control group (P＜0.05). After treatment，the ulcer area of foot in the study group was significantly less than that in the control group，and the healing rate was significantly higher than that in the control group (P＜0.05). The median nerve conduction velocity and peroneal nerve conduction velocity of lower limbs in the study group were significantly faster than those in the control group (P＜0.05). Conclusion：Huoxue Shengji decoction combined with autologous bone marrow stem cell transplantation can effectively improve the therapeutic effect of diabetic foot patients，promote wound healing，accelerate angiogenesis，help to establish collateral circulation as soon as possible，and achieve good clinical efficacy.

参考文献/References:

[1] Zhang P，Lu J，Jing Y，et al. Global epidemiology of diabetic foot ulceration：a systematic review and metaanalysis[J]. Ann Med,2017,49(2):106116.
[2] 马 婧,冉兴无.糖尿病足的规范化诊断与治疗[J].中华内科杂志,2016,55(8):648650.
[3] 马英丽,姬秋和.清创换药联合康复新液对糖尿病足溃疡的临床疗效观察[J].陕西医学杂志,2016,45(5):636.
[4] 中华医学会糖尿病学分会,中华医学会感染病学分会,中华医学会组织修复与再生分会,等.中国糖尿病足防治指南(2019版)(Ⅰ)[J].中华糖尿病杂志,2019,11(2):92108.
[5] 中华中医药学会糖尿病分会.糖尿病足中医诊疗标准[J].世界中西医结合杂志,2011,6(7):618625.
[6] 杨志光.复元活血汤联合生肌玉红膏治疗糖尿病足的临床观察[J].陕西中医,2015,36(9)：11761177.
[7] 左文仁，付丽媛. 糖尿病下肢血管病变及糖尿病足的中医治疗研究进展[J]. 中医药导报，2015,21(8):8587.
[8] 李建秀,于红俊,孙文亮,等.桃红四物汤对老年气阴两虚兼血瘀型糖尿病足患者血清CRP水平及IL6水平影响研究[J].陕西中医,2018,39(2):196198.
[9] Sveceny J，Sykova E，Tichy M，et al. New options for therapeutic revascularization in lower extremity limb ischemia linked to the diabetic foot syndrome by autologous stem cell transplantation[J]. Cas Lek Cesk,2015,154(4):161167.
[10] Vouillarmet J，Bourron O，Gaudric J，et al. Lowerextremity arterial revascularization：Is there any evidence for diabetic foot ulcerhealing?[J]. Diabetes Metab,2016,42(1):415.
[11] 何雄文，牛美兰. 活血生肌汤对糖尿病足末梢循环的干预作用[J]. 中国老年学杂志,2017,3(37) ：629630. 
[12] 李金花,李 军.地黄叶化学成分及药理作用研究进展[J].中国老年学杂志,2016,36(19):49264927.
[13] 李海刚,胡晒平,周 意,等.川芎主要药理活性成分药理研究进展[J].中国临床药理学与治疗学,2018,23(11):13021308.
[14] 孙 妍,商庆辉.乳香中三萜类化合物和药理活性的研究进展[J].环球中医药,2016,9(5):616620.

相似文献/References:

[1]冯海霞,彭新宇,董 峰.阳和汤加减联合银离子敷料治疗糖尿病足溃疡临床研究[J].陕西中医,2021,(7):900.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.023]
[2]宋珊珊,李大勇,李 鑫,等.一效膏治疗糖尿病足临床研究[J].陕西中医,2021,(9):1236.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.022]
　SONG Shanshan,LI Dayong,LI Xin,et al.Clinical study on Yixiao ointment in treating diabetic foot[J].,2021,(10):1236.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.022]
[3]吕春燕,徐旭英.名中医徐旭英基于补托法治疗糖尿病足慢性骨髓炎经验[J].陕西中医,2024,(3):391.[doi:DOI:10.3969/j.issn.1000-7369.2024.03.024]

更新日期/Last Update: 2019-10-23