[1]乔峰,强文娟,高东,等.葛根芩连汤配合针刺治疗溃疡性结肠炎活动期大肠湿热证临床研究*[J].陕西中医,2019,(11):1516-1519.
　QIAO Feng,QIANG Wenjuan,GAO Dong,et al.Gegen Qinlian decoction combined with acupuncture for ulcerative colitis with large intestine dampheat syndrome at active stage[J].,2019,(11):1516-1519.
点击复制

葛根芩连汤配合针刺治疗溃疡性结肠炎活动期大肠湿热证临床研究*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年11期
页码:
1516-1519
栏目:
临床研究
出版日期:
2019-11-05

文章信息/Info

Title:
Gegen Qinlian decoction combined with acupuncture for ulcerative colitis with large intestine dampheat syndrome at active stage
文章编号:
DOI:10.3969/j.issn.10007369.2019.11.008
作者:
乔峰1; 强文娟2; 高东2; 徐长青3
1.陕西省榆林市中医医院中医内科（榆林 719000）；2.陕西省榆林市中医医院消化内科 （榆林 719000）；3.咸阳职业技术学院科研处 （咸阳 712000）
Author(s):
QIAO Feng; QIANG Wenjuan; GAO Dong; et al.
Chinese Medicine Internal Medicine,Yulin Traditional Chinese Medicine Hospital in Shaanxi Province（Yulin 719000)
关键词:
溃疡性结肠炎; 大肠湿热证; 活动期; 葛根芩连汤; 针刺; 临床疗效
Keywords:
Key words Ulcerative colitis; Large intestine dampheat syndrome; Active stage; Gegen Qinlian decoction; Acupuncture; Clinical effect
分类号:
R516.1
文献标志码:
A
摘要:
摘要目的： 评价葛根芩连汤配合针刺治疗溃疡性结肠炎活动期大肠湿热证的临床疗效。方法： 将纳入标准的120例患者，采用随机分配方法分为观察组和对照组各60例，研究中脱落8例，最终完成112例，观察组57例，对照组55例，对照组给予枯草杆菌二联活菌肠溶胶囊配合美沙拉嗪肠溶片，3月为1疗程；观察组给予经方葛根芩连汤配合针刺治疗，3月为1疗程。结果： 两组患者治疗后腹泻、脓血便、腹痛、里急后重均较治疗前改善（P＜005）；且治疗后观察组均低于对照组（P＜005）；两组患者治疗后肠道症状、全身症状、情感能力、社会能力均较治疗前改善（P＜005）；且治疗后观察组均高于对照组（P＜005）；两组患者治疗后黏膜病变分级与治疗前比较均具有差异（P＜005）；治疗后观察组与对照组比较差异具有统计学意义（χ2=9.426，P=0041）；两组治疗后血清IL8、TNFα水平均较治疗前降低（P＜001）；治疗后观察组均低于对照组；两组治疗前结肠镜下病变活动水平无显著性差异（t=0.584，P=0608）；治疗后观察组结肠镜下病变活动水平低于对照组（P＜005）。结论：葛根芩连汤配合针刺能够明显改善溃疡性结肠炎活动期大肠湿热证的临床症状、提高生存质量、改善肠黏膜及降低血清炎性因子表达水平。
Abstract:
AbstractObjectives:To evaluate the clinical effect of classical prescription of Gegen Qinlian decoction combined with acupuncture for ulcerative colitis with large intestine dampheat syndrome at active stage.Methods:120 cases patients was selected that accorded with the inclusion criteria was randomly divided into the experimental group and the control group,and each group had 60 cases patients.There were 8 cases of shedding in the study,112 cases were finally completed,including 57 cases in the experimental group and 55 cases in the control group.In the control group,bacillus subtilis entericcoated capsules with live bacteria and mesalazine entericcoated tablets were given and for a course of 3 months;the experimental group were given the classical prescription of Gegen Qinlian decoction combined with acupuncture treatment,3 months for a course of treatment.Results:Diarrhea,purulent blood stool,abdominal pain and tenesmus were all improved in both groups after treatment (P＜005);after treatment,and the experimental group were lower than the control group (P＜005).The intestinal symptoms,systemic symptoms,emotional ability and social ability of the patients in the two groups were all improved after treatment (P＜005);after treatment,and the experimental group were all higher than those in the control group (P＜005).There were differences in the grading of mucosal lesions between the two groups after treatment and before treatment (P＜005).After treatment,the difference between the experimental group and the control group was statistically significant (χ2=9.426,P=0.041).Serum TNFα and IL8 levels in both groups were lower after treatment than before treatment,and the differences were statistically significant (P＜0.01).After treatment,the expression levels in the experimental group were lower than those in the control group.There was no significant difference in the activity level of lesions under colonoscopy between the two groups before treatment (t=0.584,P=0.608).After treatment,the activity level of colonoscopy in the experimental group was lower than that in the control group(P＜005).Conclusions:The classical prescription of Gegen Qinlian decoction combined with acupuncture can obviously improve clinical symptoms〖LM〗 of ulcerative colitis with large intestine dampheat syndrome at active stage,improve the quality of survival,improve intestinal mucosa and decrease the expression level of serum inflammatory factors.

参考文献/References:

[1]Nishida A,Imaeda H,Inatomi O,et al.The efficacy of fecal microbiota transplantation for patients with chronic pouchitis:A case series[J].Clin Case Rep,2019,7(4):782788.
[2]Miranda BJ,Dieguez L,Rodriguez G,et al.Cases report:severe colonic bleeding in ulcerative colitis is refractory to selective transcatheter arterial embolization[J].BMC Gastroenterol,2019,19(1):55.
[3]陈良荣,绳荣湍,邱燕婷,等.健脾清热活血方对溃疡性结肠炎患者疗效及NLRP6、Caspase1、IL8的影响[J].中华中医药杂志,2018,33(12):57315734.
[4]杨倩,杜朋丽,赵丹阳,等.化浊解毒方治疗溃疡性结肠炎的临床疗效及对患者神经内分泌因子的影响[J].中国中西医结合消化杂志,2019,27(4):247250.
[5]李博林,张纨,王志坤,等.化浊解毒方治疗溃疡性结肠炎的临床疗效及对神经内分泌免疫网络的影响[J].中国中西医结合杂志,2019,39(2):184188.
[6]陈凯军,李彩丽.针药结合治疗活动期湿热型溃疡性结肠炎疗效观察[J].中国针灸,2015,35(5):435438.
[7]刘大铭,王新月.难治性溃疡性结肠炎中医病因病机探讨[J].中医杂志,2011,52(24):21562157.
[8]赵益,赖小东,叶争荣,等.葛根芩连汤对溃疡性结肠炎模型大鼠抗氧化及抗炎的作用机制[J].中华中医药杂志,2016,31(5):17411745.
[9]中华医学会消化病学分会炎症性肠病协作组.对我国炎症性肠病诊断治疗规范的共识意见[J].胃肠病学,2007,12(8):488495.
[10]李军祥,陈誩.溃疡性结肠炎中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2018,26(2):105111.
[11]Truelove SC,Witts LJ.Cortisone in ulcerative colitis;finalreport on a therapeutic trial[J].Br Med J,1955,2(4947):10411048.
[12]国家食品药品监督管理总局.新药(中药)临床研究指导原则[M].北京:中国医药科技出版社,2002:45.
[13]Guyatt G,Mitchell A,Irvine EJ,et al.A new measure of health status for clinical trials in inflammatory bowel disease[J].Gastroenterology,1989,96(3):804810.
[14]Schoepfer AM,Beglinger C,Straumann A,et al.Ulcerative colitis:correlation of the Rachmilewitz endoscopic activity index with fecal calprotectin,clinical activity,Creactive protein,and blood leukocytes[J].Inflamm Bowel Dis,2009,15(12):18511858.
[15]Vucelic B.Inflammatory bowel disease:controversies in the use of diagnostic procedure[J].Dig Dis,2009,27(3):269277.
[16]王云龙,赵晓峰,郭海.扶正平溃汤对溃疡性结肠炎患者肠道菌群与致炎细胞因子的影响[J].陕西中医,2017,38(8):10161017.
[17]李竹林,赵瑛.高强度间歇性运动联合药物治疗溃疡性结肠炎疗效及对患者细胞因子水平影响研究[J].陕西医学杂志,2019,48(7):909912.

相似文献/References:

[1]陈 岚,贾 波△,邓怀涵,等.基于“逆流挽舟”法探索人参败毒散对溃疡性结肠炎模型大鼠〖JZ〗胃肠功能的影响及作用机制*[J].陕西中医,2019,(3):283.
[2]陈立冬,刘智慧,于 蕊.康复新液灌肠联合美沙拉嗪治疗溃疡性结肠炎疗效研究*[J].陕西中医,2019,(9):1187.
[3]史英,张铁△,祝斌野,等.溃结2号方治疗脾虚湿盛型溃疡性结肠炎临床研究*[J].陕西中医,2019,(11):1520.
　SHI Ying,ZHANG Tie,ZHU Binye,et al.Clinical observation on Kuijie No.2 recipe in treating ulcerative colitis of spleen deficiency and dampness[J].,2019,(11):1520.
[4]赵克学,徐 辰,戴高中,等.愈疡膏外敷联合西药治疗复发型活动期溃疡性结肠炎临床研究*[J].陕西中医,2020,(5):600.[doi:DOI:10.3969/j.issn.10007369.2020.05.013]
　ZHAO Kexue,XU Chen,DAI Gaozhong,et al.Observation on the efficacy of Yuyang plaster combined with western medicine in the treatment of recurrent active ulcerative colitis[J].,2020,(11):600.[doi:DOI:10.3969/j.issn.10007369.2020.05.013]
[5]白鹏飞,张艳君,李 敏.荆芥连翘汤加减从肺论治溃疡性结肠炎疗效及对患者肠黏膜屏障功能、免疫调节、氧化应激指标的影响*[J].陕西中医,2020,(7):897.[doi:DOI:10.3969/j.issn.10007369.2020.07.017]
　BAI Pengfei,ZHANG Yanjun,LI Min..Effect of treating ulcerative colitis with nepeta forsythia decoction and its influence on intestinal barrier function,immune regulation and oxidative stress[J].,2020,(11):897.[doi:DOI:10.3969/j.issn.10007369.2020.07.017]
[6]郭 琳,王雅婷,考延磊,等.闫雪洁运用寒热并用法治疗溃疡性结肠炎经验*[J].陕西中医,2020,(8):1148.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.036]
　GUO Lin,WANG Yating,KAO Yanlei,et al.Clinical experience of YAN Xuejie in treating ulcerative colitis with the theory of combination of cold and heat[J].,2020,(11):1148.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.036]
[7]梁 想,王梅青△.参苓白术散联合美沙拉嗪治疗溃疡性结肠炎疗效研究[J].陕西中医,2020,(9):1251.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.021]
[8]袁子云,杜晓泉△.杜晓泉运用健脾调肠汤治疗溃疡性结肠炎脾虚湿热证经验总结*[J].陕西中医,2020,(12):1800.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.032]
[9]邹林焘,邹正华,杜学芳.清肠解毒汤治疗溃疡性结肠炎湿热内蕴证临床研究[J].陕西中医,2021,(5):597.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.013]
　ZOU Lintao,ZOU Zhenghua,DU Xuefang.Qingchang Jiedu decoction in the treatment of ulcerative colitis with internal accumulation of damp-heat[J].,2021,(11):597.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.013]
[10]张 波,惠永峰,李海玲,等.益脾祛湿理肠汤治疗溃疡性结肠炎疗效及对患者肠黏膜屏障功能的影响[J].陕西中医,2021,(8):1024.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.009]
　ZHANG Bo,HUI Yongfeng,LI Hailing,et al.Yipi Qushi Lichang decoction on ulcerative colitis and its influence on intestinal mucosal barrier function[J].,2021,(11):1024.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.009]

备注/Memo

备注/Memo:
*陕西省中医药管理局资助项目（2017LCMS034）
更新日期/Last Update: 2019-11-15