[1]陈宗伟,沈志涛,郑振国,等.芪苈强心胶囊配合保元汤加减治疗慢性心力衰竭临床研究*[J].陕西中医,2020,(2):191-193.
　CHEN Zongwei,SHEN Zhitao,ZHENG Zhenguo,et al.Observation on the effect of Qili Qiangxin capsules assist Baoyuan decoction in the treatment of chronic heart failure[J].,2020,(2):191-193.
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芪苈强心胶囊配合保元汤加减治疗慢性心力衰竭临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年2期
页码:
191-193
栏目:
临床研究
出版日期:
2020-02-05

文章信息/Info

Title:
Observation on the effect of Qili Qiangxin capsules assist Baoyuan decoction in the treatment of chronic heart failure
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007369.2020.02.014
作者:
陈宗伟1; 沈志涛1; 郑振国1; 杨 琦2; 唐明华2△
1.大连大学附属中山医院循环二科(大连 116001); 2.大连医科大学附属第二医院(大连 116023)
Author(s):
CHEN Zongwei; SHEN Zhitao; ZHENG Zhenguo; et al.
Cardiovascular Department Two,Affiliated Zhongshan Hospital of Dalian University(Dalian 116001)
关键词:
慢性心力衰竭;  芪苈强心胶囊;  保元汤;  心功能;  半乳糖凝集素3;  白介素6
Keywords:
Qili Qiangxin capsules;  Chronic heart failure;  Baoyuan decoction;  Cardiac function;  Galactose lectin 3;  IL-6
分类号:
R541.61
文献标志码:
A
摘要:
目的:观察芪苈强心胶囊配合保元汤加减用于慢性心力衰竭的治疗效果。方法:选取收治的慢性心力衰竭患者104例作为研究对象,运用随机数字表法将其分为观察组(52例)和对照组(52例),两组患者均接受常规治疗,对照组采用保元汤治疗,观察组同时应用芪苈强心胶囊联合保元汤治疗。观察患者治疗前及治疗后6个月的6 min步行试验的步行距离(6MWD)及纽约心脏病学会心功能分级(NYHA)、血清学指标N末端B型利尿钠肽原(NT-proBNP)、半乳糖凝集素3(Galectin-3)及白介素6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、心脏指数(CI)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室重量指数(LVMI)和室壁运动指数(WMI)、左室间隔厚度(IVST)变化情况。结果:治疗前后,两组患者比较心功能指标、Galectin-3、炎性因子指标、心室重构指标差异有统计学意义(P<0.05); 观察组与对照组患者相比,6 min步行距离、CI、LVEF、升高更为显著(P<0.05); 观察组患者NYHA分级、NT-proBNP、Galectin-3、IL-6、hs-CRP、TNF-α、LVEDD、LVESD、LVMI、WMI、IVST降低更为显著(P<0.05)。结论:芪苈强心胶囊辅助保元汤加减能够有效改善慢性心力衰竭患者心脏功能,有利于患者体内炎性因子及Galectin-3水平降低,抑制心室重构进展,患者心脏舒缩功能改善效果更佳。
Abstract:
Objective:To observe the effect of the addition and addition of Qili Qiangxin capsule assists Baoyuan decoction to reduce on the treatment of chronic heart failure.Method:104 patients with chronic heart failure were selected as the subjects of the study.The patients were randomly divided into observation group(52 cases)and control group(52 cases).The patients in the two groups were treated with routine treatment,the control group was treated with Baoyuan decoction at the same time,and the observation group was treated with Qili Qiangxin capsule supplemented with Baoyuan decoction at the same time.Results:Before and after treatment,there were significant differences in cardiac function,Galectin-3,inflammatory factors and ventricular remodeling between the two groups.Compared with the control group,the walking distance and CI,LVEF,of 6 min in the observation group were significantly higher than those in the control group(P<0.05).NYHA grade,NT-proBNP,Galectin-3,IL-6,hs-CRP,TNF-α,LVEDD,LVESD,LVMI,WMI,IVST were more significantly decreased in the observation group(P<0.05).Conclusion:Qili Qiangxin capsule and Baoyuan decoction can effectively improve the heart function of patients with chronic heart failure.It is beneficial to the decrease of inflammatory factor and Galectin-3 level in patients,inhibit the progress of ventricular remodeling,and improve the function of cardiac contraction.

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备注/Memo

备注/Memo:
*辽宁省自然科学基金资助项目(201705402)
更新日期/Last Update: 2020-03-31