[1]李倩薇,任 明,焦红军.神曲消食口服液联合枸橼酸莫沙必利治疗儿童功能性消化不良疗效研究*[J].陕西中医,2020,(2):198-201.
　LI Qianwei,REN Ming,JIAO Hongjun..Therapeutic effect of Shenqu Xiaoshi oral liquid combined with mosapride citrate on children with functional dyspepsia[J].,2020,(2):198-201.
点击复制

神曲消食口服液联合枸橼酸莫沙必利治疗儿童功能性消化不良疗效研究*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年2期
页码:
198-201
栏目:
临床研究
出版日期:
2020-02-05

文章信息/Info

Title:
Therapeutic effect of Shenqu Xiaoshi oral liquid combined with mosapride citrate on children with functional dyspepsia
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007369.2020.02.016
作者:
李倩薇; 任 明; 焦红军
郑州大学第二附属医院药学部(郑州 450014)
Author(s):
LI Qianwei; REN Ming; JIAO Hongjun.
Department of Pharmacy,the Second Affiliated Hospital of Zhengzhou University(Zhengzhou 450014)
关键词:
功能性消化不良;  神曲消食口服液;  枸橼酸莫沙必利;  胃动素;  胃泌素;  生长抑素;  胃排空
Keywords:
Functional dyspepsia;  Shenqu Xiaoshi oral liquid;  Mosapride citrate;  Gastrin;  Motilin;  Somatostatin;  Gastric emptying
分类号:
R725.7
文献标志码:
A
摘要:
目的:观察神曲消食口服液联合枸橼酸莫沙必利治疗小儿功能性消化不良的疗效。方法:100例功能性消化不良儿童随机分为对照组(n=42)口服枸橼酸莫沙必利,与观察组(n=58)口服神曲消食口服液和枸橼酸莫沙必利,治疗14 d。对治疗前后患者临床症状、疗效、胃肠激素水平、胃排空情况进行评价。结果:治疗后,观察组主症总积分和次症总积分下降明显(P<0.05)。观察组总有效率为91.3%,高于对照组的76.19%(P<0.05)。观察组GAS、MOT升高显著,SST水平下降显著(P<0.05)。餐后不同时间点,观察组胃排空优于对照组(P<0.05)。结论:神曲消食口服液联合枸橼酸莫沙必利在治疗儿童功能性消化不良中临床疗效显著。
Abstract:
Objective:To observe the clinical efficacy of Shenqu Xiaoshi oral liquid combined with mosapride citrate in the treatment of functional dyspepsia in children.Methods:One hundred children with functional dyspepsia were randomly assigned.The control group(n=42)received moxapride citrate orally,while the observation group(n=58)received both Shenqu Xiaoshi oral liquid and moxapride citrate for 14 days.Clinical symptoms,curative effect,gastrointestinal hormone level and gastric emptying were evaluated before and after treatment.Results:After treatment,the scores of major and minor clinical symptom in the observation group decreased significantly(P<0.05).The total effective rate of the observation group was 91.3%,higher than 76.19% of the control group(P<0.05).In the observation group,GAS and MOT increased significantly and SST decreased significantly(P<0.05).Gastric emptying in the observation group was better than that in the control group at different postprandial time points(P<0.05).Conclusion:Shenqu Xiaoshi oral liquid combined with mosapride citrate in the treatment of children functional dyspepsia clinical efficacy is significant.

参考文献/References:

[1] Enck P,Azpiroz F,Boeckxstaens G,et al.Functional dyspepsia[J].Nature Reviews,2017,3:17081.
[2] Douglas A.Drossman.Functional gastrointestinal disorders:history,pathophysiology,clinical features,and rome IV[J].Gastroenterology,2016,150(6):1262-1279.
[3] Carbone F,Tack J,Hoffman I.The Intragastric pressure measurement:a novel method to assess gastric accommodation in functional dyspepsia children[J].Journal of Pediatric Gastroenterology and Nutrition,2017,64(6):918-924.
[4] 唐旭东,王凤云,李慧臻,等.痞满中医临床实践指南(2018)[J].中医杂志,2019,60(17):1520-1530.
[5] 李芳芳,黄巨霞.雷贝拉唑联合莫沙必利对反流性食管炎患者幽门螺杆菌感染及炎症因子水平影响研究[J].陕西医学杂志,2019,48(10):1378-1380.
[6] Daisuke M,Makoto A,Takeshi T,et al.Mosapride citrate increases postprandial glucagon-like peptide-1,insulin,and gene expression of sweet taste receptors[J].Digestive Diseases and Sciences,2015,60(2):345-353.
[7] 李军祥,陈 誩,李 岩.功能性消化不良中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2017,25(12):889-894.
[8] 张声生,赵鲁卿.功能性消化不良中医诊疗专家共识意见(2017)[J].中华中医药杂志,2017,32(6):2595-2598.
[9] 马 融,胡思源,王俊宏,等.小儿厌食中药新药临床试验设计与评价技术指南[J].药物评价研究,2015,38(3):244-250.
[10] 钟子劭,黄穗平,吕 林,等.健脾理气法治疗脾虚气滞证功能性消化不良的疗效及近端胃排空功能研究[J].中华中医药杂志,2016,31(11):4752-4755.
[11] 于 意,许春娣.儿童功能性消化不良研究现状及诊疗共识解读[J].现代实用医学,2014,26(11):1329-1331.
[12] 高 宏.综合干预结合药物治疗功能性消化不良540例[J].陕西医学杂志,2016,45(11):1566.
[13] 张清清,孟 焱.养心汤加减联合草酸艾司西酞普兰片治疗抑郁症临床研究[J].中医学报,2017,32(6):1011-1014.
[14] 赵洪武.辨证论治慢性萎缩性胃炎50例[J].陕西中医,2017,38(7):911-912.
[15] Curran MP,Robinson DM.Mosapride in gastrointestinal disorders[J].Drugs,2008,68(7):981-991.
[16] 张徐雯,周 驰,王晓彤,等.白术散加减对胃寒型功能性消化不良小鼠胃肠功能的影响[J].中国医学科学院学报,2015,37(4):435-439.
[17] Deloose E,Verbeure W,Depoortere I,et al.Motilin:from gastric motility stimulation to hunger signalling[J].Nature Reviews,2019,15(4):238-250.
[18] 于惠玲,鲁素彩,王阳阳,等.老年功能性消化不良重叠腹泻型肠易激综合征的胃肠激素水平变化[J].中国老年学杂志,2015,35(21):6175-6176.
[19] 左 甲,杨改琴,秦彩娟,等.针刺背俞穴对CAG模型大鼠胃泌素、胃动素、表皮生长因子的影响[J].陕西中医,2017,38(11):1613-1614.
[20] Haruma K,Kamada T,Manabe N,et al.Old and new gut hormone,gastrin and acid suppressive therapy[J].Digestion,2018,97(4):340-344.
[21] 马晓颖,史丽萍,张 健.半夏泻心汤联合莫沙必利治疗功能性消化不良疗效及对患者血浆胃动素水平的影响[J].陕西中医,2018,39(10):1399-1401.

相似文献/References:

[1]*国家自然科学基金资助项目 (8777).功能性消化不良肝郁脾虚证患者C型钠尿肽与神经营养因子相互作用机制研究进展*[J].陕西中医,2019,(9):1310.
[2]展立芬,邢博文,覃思敏,等.心胃相关理论在功能性消化不良中的运用及机制探析[J].陕西中医,2021,(8):1103.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.029]
　ZHAN Lifen,XING Bowen,Qin Simin,et al.Application and mechanism of psychogastric related theory in functional indigestion[J].,2021,(2):1103.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.029]
[3]李 芳,鱼 涛,郭亚男,等.柴枳和胃胶囊治疗功能性消化不良餐后不适综合征肝郁脾虚证疗效研究[J].陕西中医,2022,(9):1222.[doi:DOI:10.3969/j.issn.1000-7369.2022.09.016]
　LI Fang,YU Tao,GUO Yanan,et al.Clinical effect on Chaizhi Hewei capsule in the treatment of functional dyspepsia postprandial distress syndrome of Ganyu Pixu[J].,2022,(2):1222.[doi:DOI:10.3969/j.issn.1000-7369.2022.09.016]
[4]林瑞芳,俞赟丰,阳凌峰,等.基于肠道菌群探讨中医药治疗功能性消化不良研究进展[J].陕西中医,2022,(11):1647.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.037]
　LIN Ruifang,YU Yunfeng,YANG Lingfeng,et al.Research progress on treatment of functional dyspepsia with traditional Chinese medicine based on intestinal flora[J].,2022,(2):1647.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.037]
[5]苏坤涵,刘万里.从“善治脾者,能调五脏”论治功能性消化不良[J].陕西中医,2023,(2):216.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.018]
　SU Kunhan,LIU Wanli.Explore the treatment of functional dyspepsia from “Those who are good at curing the spleen can regulate the five internal organs”[J].,2023,(2):216.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.018]
[6]熊 啸,徐天舒.基于脑肠互动探析中医药改善功能性消化不良的作用机制[J].陕西中医,2023,(2):224.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.020]
　XIONG Xiao,XU Tianshu.Exploring the mechanism of traditional Chinese medicine to improve functional dyspepsia based on brain-gut interaction[J].,2023,(2):224.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.020]
[7]姚函伶,乐 薇,范建超,等.电针对功能性消化不良模型大鼠行为学及下丘脑5-HT3R、CRH mRNA表达的影响[J].陕西中医,2023,(6):699.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.004]
　YAO Hanling,LE Wei,FAN Jianchao,et al.Effect of electroacupuncture on behaviors and expression of 5-HT3R and CRH mRNA in hypothalamics of functional dyspepsia rats[J].,2023,(2):699.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.004]
[8]谢家诚,马晓聪,杨靖芸,等.罗伟生从肝胃论治功能性消化不良经验[J].陕西中医,2023,(6):766.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.019]
[9]陈思清,徐 寅,蔺晓源,等.四磨汤对肝脾气滞证功能性消化不良大鼠十二指肠低度炎症及肥大细胞脱颗粒的影响[J].陕西中医,2023,(10):1344.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.003]
　CHEN Siqing,XU Yin,LIN Xiaoyuan,et al.Effect of Simo decoction on low-grade inflammation of duodenum and degranulation of mast cells in rats with functional dyspepsia[J].,2023,(2):1344.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.003]
[10]耿 琦,李敬伟,凌江红,等.半夏泻心汤对功能性消化不良大鼠抑郁状态及促肾上腺皮质激素释放因子相关通路的影响[J].陕西中医,2024,(2):147.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.001]
　GENG Qi,LI Jingwei,LING Jianghong,et al.Effects of Banxia Xiexin decoction on depressive state and CRF-related pathways in rats with functional dyspepsia[J].,2024,(2):147.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.001]

备注/Memo

备注/Memo:
*郑州市科学技术局资助项目(172PKJHM351)
更新日期/Last Update: 2020-03-31