[1]王雪梅,汤久慧,王茂生△,等.参芪杀白汤为主联合化疗治疗急性白血病合并脾周围炎临床研究*[J].陕西中医,2020,(2):202-205.
　Xuemei,TANG Jiuhui,WANG Maosheng,et al.Acute leukemia with perisplenitis treated by Shenqi Shabai decoction with chemotherapy WANG[J].,2020,(2):202-205.
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参芪杀白汤为主联合化疗治疗急性白血病合并脾周围炎临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年2期
页码:
202-205
栏目:
临床研究
出版日期:
2020-02-05

文章信息/Info

Title:
Acute leukemia with perisplenitis treated by Shenqi Shabai decoction with chemotherapy WANG
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007369.2020.02.017
作者:
王雪梅1; 汤久慧2; 王茂生2△; 李 君2
1.河北省廊坊市第四人民医院中医科(廊坊 065700); 2.河北省廊坊市中医医院血液科(廊坊 065000)
Author(s):
Xuemei; TANG Jiuhui; WANG Maosheng; et al.
Department of Traditional Chinese Medicine,the Fourth People's Hospital of Langfang(Langfang 065000)
关键词:
参芪杀白汤;  丹香解毒消癥散;  急性髓细胞白血病;  急性淋巴细胞白血病;  化疗;  脾周围炎
Keywords:
Shenqi Shabai decoction;  Danxiang Jiedu Xiaozheng powder;  Acute myeloid leukemia;  Acute lymphocytic leukemia;  Chemotherapy;  Perisplenic inflammation
分类号:
R733.71
文献标志码:
A
摘要:
目的:观察参芪杀白汤为主联合化疗治疗白血病伴发脾周围炎患者临床疗效及患者脾肿大范围、疼痛程度、局部皮温及彩超脾周围炎相关表现的治疗前后改善情况。方法:在DA方案或VDCP±L-Asp方案化疗基础上,采用益气养阴,化瘀消癥中药,自拟参芪杀白汤内服、丹香解毒消癥散外敷治疗伴脾周围炎急性髓细胞白血病或急性淋巴细胞白血病。结果: 白血病疗效表明,观察组CR率69.0%,观察组46.3%; 总有效率观察组88.1%,明显优于对照组(68.3%,P<0.05); 脾周围炎治疗效果观察组痊愈率59.5%,对照组39.0%; 总有效率观察组92.9%,优于对照组(82.9%,P<0.05)。结论:益气养阴、化瘀消癥中药内服外用治疗急性白血病伴发脾周围炎可提高完全缓解率,既可清热解毒通络以止痛,又可软坚消癥治疗辅助治疗白血病,且未见明显不良反应。
Abstract:
Objective:To observe clinical effect of internal and external using Shenqi Shabai decoction combined with chemotherapy in the treatment of leukaemia with perisplenitis,and the improvement of splenomegaly,the degree of pain,local skin temperature and manifestations of perisplenitis of transabdominal ultrasonography after treatment.Methods:On the basis of chemotherapy using DA or VDCP±L-Asp regimen,patients with acute myeloid leukemia or acute lymphocytic leukemia with perisplenitis were given Shenqi Shabai decoction orally and Danxiang Jiedu Xiaozheng powder for external use.Results: The CR rate(69.0% vs 46.3%)and total effective rate(88.1% vs 68.3%)in the observation group were significantly higher than those in the control group(both P<0.05).The cure rate of perisplenitis(59.5% vs 39.0%)and total effective rate of perisplenitis(92.9% vs 82.9%)in the observation group were significantly higher than those in the control group(both P<0.05).Conclusion:It is safe and efficient to carry out the combined use of Chinese herbal medicine for reinforcing Qi and nourishing yin and removing blood stasis and lumps and chemotherapy in the treatment of acute leukemia with perisplenitis,which can improve the complete remission rate.Moreover,it not only can clear heat and toxic matter and dredge collaterals to relieve pain,but also can soften hard masses dissipate stagnation as an assistant way of treating leukemia,without obvious toxic and side effects.

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备注/Memo

备注/Memo:
*河北省廊坊市科技支撑计划项目(2014013012C)
更新日期/Last Update: 2020-03-31