[1]张 萍,金 昕,陶 枫△.从胃肠肽角度论中药抑制食欲研究进展*[J].陕西中医,2020,(2):261-265.
　ZHANG Ping,JIN Xin,TAO Feng..Progress on appetite suppression of traditional Chinese medicine from the perspective of gastrointestinal peptides[J].,2020,(2):261-265.
点击复制

从胃肠肽角度论中药抑制食欲研究进展*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年2期
页码:
261-265
栏目:
综述
出版日期:
2020-02-05

文章信息/Info

Title:
Progress on appetite suppression of traditional Chinese medicine from the perspective of gastrointestinal peptides
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007369.2020.02.034
作者:
张 萍1; 金 昕2; 陶 枫2△
1.上海中医药大学研究生院(上海 201203); 2.上海中医药大学附属曙光医院内分泌科(上海201203)
Author(s):
ZHANG Ping; JIN Xin; TAO Feng.
Shanghai University of Traditional Chinese Medicine(Shanghai 201203)
关键词:
肥胖;  胃肠肽;  食欲抑制;  中药;  四气五味;  胆囊收缩素
Keywords:
Obesity;  Gastrointestinal peptides;  Appetite suppression;  Traditional Chinese medicine;  Four properties and five tastes;  CCK
分类号:
R589.2
文献标志码:
A
摘要:
肥胖患病率逐年升高,严重危害人民体质和健康。抑制食欲一直是减肥领域的研究热点,胃肠肽是调节食欲的重要因子之一。多项研究报道多种中药或复方可以调节胆囊收缩素(CCK)、胰高血糖素样肽-1(GLP-1)和酪酪肽(PYY)影响食欲。本文整理近5年相关中药的研究报道发现:大黄、绿茶、啤酒花、葡萄籽、地黄、吴茱萸、葛根、黄连等单味药及柴疏四君汤、七味白术散等复方调节胃肠肽的报道较多; 其中,葛根和黄连调节GLP-1抑制食欲效应和机制的研究已经取得了一定的进展。中医学认为食欲亢进与脏腑功能失调有关,而四气五味中药理论也支持利用性味各异的中药平衡脏腑功能的治法。结合现代医学味觉内分泌学说,中药调节胃肠肽抑制食欲值得进一步研究。
Abstract:
The prevalence of obesity is increasing year by year,which seriously endangering people's physique and health.Appetite suppression has been a hot topic in the field of weight loss,gastrointestinal peptides are one of the important factors for regulating appetite.A number of studies have reported that a variety of traditional Chinese medicines or compounds can regulate cholecystokinin(CCK),glucagon-like peptide-1(GLP-1)and peptide YY(PYY).In this paper,the research reports on TCM in the past five years were summarizedand,and it was found that rhubarb,green tea,hops,grape seed,evodia rehmanniae,rutaecarpa,puerariae lobata,coptidis,ect as well as Chaishu Sijun decoction,Qiwei Baizhu powder and other compounds can regulate gastrointestinal peptides.Among them,studies on the appetite suppressing effect and mechanisms of puerariae lobata and coptis regulating GLP-1 appetite suppression have made some progress.In Chinese medicine,hyperappetite is associated with visceral dysfunction and the theory of four properties and five tastes also supports the use of different flavors of TCM to balance the functions of viscera.Combined with the endocrinology of taste receptors,the research on the inhibition of hyperappetite by regulating gastrointestinal peptides is worthy of further study.

参考文献/References:

[1] Seidell JC,Halberstadt J.The global burden of obesity and the challenges of prevention[J].Ann Nutr Metab,2015,66(2):7-12.
[2] Andermann ML,Lowell BB.Toward a wiring diagram understanding of appetite control[J].Neuron,2017,95(4):757-778.
[3] Andreas S,Yvette T.Gut-brain neuroendocrine signaling under conditions of stress-focus on food intake-regulatory mediators[J].Provisional,2018,9(498):1-29.
[4] 杨文英.肠道激素与肥胖和糖尿病[J].中国糖尿病杂志,2015,12(12):1142-1148.
[5] 钱 程,杨 蔚,麻 静.胃肠激素与多囊卵巢综合征的研究探索[J].上海交通大学学报:医学版,2017,37(3):414-419.
[6] 沈晓东,王玉英,华卫国.具有食欲抑制作用中药的研究进展[J].上海中医药杂志,2008,42(5):95-97.
[7] Kaelberer MM,Boharquez DV.The now and then of gut-brain signaling[J].Brain Res,2018,23(18):30162-30168.
[8] 陈家伦,宁 光,潘长玉,等.临床内分泌学[M].上海:上海科学技术出版社,2011:1567-1568.
[9] LoC C,Sean DW,Hibbard SK,et al.Intraperitoneal CCK and fourth-intraventricular apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats[J].Endocrinology,2014,155(5):1700-1707.
[10] D'Agostino G,Lyons DJ,Cristiano C,et al.Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit[J].eLife,2016,5(5):1-15.
[11] 王 磊,李 峨,莫爵飞.疏肝化瘀法对人及豚鼠血浆CCK及血脂影响的实验研究[J].时珍国医药,2015,26(12):3034-3036.
[12] 李 聪,谢 鸣,赵荣华.柴疏四君汤对肝郁-脾虚-肝郁脾虚不同证候模型大鼠消化系统功能的影响[J].中华中医药杂志,2014,29(1):72-75.
[13] 陈旻丹,胡京红,马 捷,等.脾虚四号方含药血清对功能性腹泻脾虚证大鼠离体结肠平滑肌细胞的影响[J].北京中医药大学学报,2017,40(7):297-301.
[14] 龚梦鹃,岳 贺,周祥羽,等.基于尿液代谢组学的交泰丸治疗失眠的作用研究[J].中药新药与临床药理,2017,28(5):654-658.
[15] Li F,Li S,Liu Y,et al.Effect of Heweianshen decoction on Orexin-A and cholecystokinin-8 expression in rat models of insomnia[J].Evidence-Based Complementary and Alternative Medicine,2016,2016:1-4.
[16] 凌 燕,冼绍祥,陈汉裕,等.清心神安方对失眠大鼠脑组织神经递质含量的影响[J].中药新药与临床药理,2018,29(1):23-26.
[17] Fang B,Shen J,Zhang H,et al.Effect of emodin on mobility signal transduction system of gallbladder smooth muscle in Guinea pig with cholelithiasis[J].Asian Pacific Journal of Medicine,2016,9(10):1013-1018.
[18] 王 鹏,高富合,单娜娜,等.银杏叶提取物对血管性痴呆小鼠大脑皮层生长抑素及胆囊收缩素表达的影响[J].中国药业,2013,22(17):7-9.
[19] He X,Cai Q,Li J,et al.Involvement of brain-gut axis in treatment of cerebral infarction by β-asaron and paeonol[J].Neuroscience Letters,2018,666:78-84.
[20] Planes MD,Lapez NR,Gonzalez BC,et al.In vitro effect of green tea and turmeric extracts on GLP-1 and CCK secretion:the effect of gastrointestinal digestion[J].Food & Function,2018,9(10):5245-5250.
[21] Foure M,Dugardin C,Foligne B,et al.Chicory roots for prebiotics and appetite regulation:a pilot study in mice[J].J Agric Food Chem,2018,66(25):6439-6449.
[22] Yamazaki T,Morimoto KY,Koizumi K,et al.Secretion of a gastrointestinal hormone,cholecystokinin,by hop-derived bitter components activates sympathetic nerves in brown adipose tissue[J].The Journal of Nutritional Biochemistry,2019,64(64):80-87.
[23] 操寄望,余 光,罗和生,等.吴茱萸碱对大鼠结肠运动的影响[J].武汉大学学报:医学版,2017,38(6):987-994.
[24] 杜丽东,牛亭惠,吴国泰,等.当归对血虚便秘模型小鼠胃肠激素与酪氨酸激酶受体C-kit表达的影响[J].中国临床药理学杂志,2018,34(10):1195-1198.
[25] 纪立农,邹大进,洪天配,等.GLP-1受体激动剂临床应用专家指导意见[J].中国糖尿病杂志,2018,26(5):353-361.
[26] Nonogaki K,Kaji T.Liraglutide,a GLP-1 receptor agonist,which decreases hypothalamic 5-HT2A receptor expression,reduces appetite and body weight independently of serotonin synthesis in mice[J].Journal of Diabetes Research,2018,2018(6482958):1-6.
[27] Knudsen LB,Secher A,Hecksher SR,et al.Long-acting glucagon-like peptide-1 receptor agonists have direct access to and effects on pro-opiomelanocortin/cocaine-and amphetamine-stimulated transcript neurons in the mouse hypothalamus[J].J Diabetes Investig,2016,7(S1):56-63.
[28] Secher A,Jelsing J,Baquero AF,et al.The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss[J].Journal of Clinical Investigation,2014,124(10):4473-4488.
[29] Lu K,Chen X,Yan J,et al.The Effect of feeding behavior on hypothalamus in obese type 2 diabetic rats with glucagon-like peptide-1 receptor agonist intervention[J].Obesity Facts,2018,11(3):181-194.
[30] Davies MJ,Bergenstal R,Bode B,et al.Efficacy of liraglutide for weight loss among patients with type 2 diabetes:the SCALE Diabetes randomized clinical trial[J].JAMA,2015,314(7):687-699.
[31] Ard J,Cannon A,Lewis CE,et al.Efficacy and safety of liraglutide 3.0 mg for weight management are similar across races:subgroup analysis across the SCALE and phase II randomized trials[J].Diabetes Obes Metab,2016,18(4):430-435.
[32] 侯瑞芳,徐 杰,陈 思,等.清化颗粒对高脂饲料诱导肥胖模型大鼠的减重效应及血清瘦素的影响[J].中华中医药杂志,2016,31(3):1005-1008.
[33] Li J,Xu J,Hou R,et al.Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice[J].Biomedicine & Pharmacotherapy,2017,89(89):10-17.
[34] 王 斌,吴深涛,王 亭,等.化浊解毒方对糖尿病大鼠血清GLP-1的影响[J].中华中医药杂志,2016,31(1):269-271.
[35] 高长花,余文珍,施 红,等.石斛合剂对糖尿病模型大鼠胰高血糖素样肽-1的影响[J].中医临床研究,2013,5(23):5-7.
[36] 林心君,刘言凤,高长花,等.石斛合剂通过GLP-1/β-Catenin信号通路促进胰岛细胞增殖的机制[J].中华中医药杂志,2016,31(8):3266-3269.
[37] 朱 彤,唐旭东,万嘉嘉,等.脾虚4号方对功能性腹泻脾虚证模型大鼠结肠组织胰高血糖素肽1受体表达的影响[J].辽宁中医杂志,2016,43(1):183-186.
[38] 何雪薇,胡齐鸣.健脾益气化湿法对2型糖尿病(脾虚夹湿型)患者GLP-1的影响[J].辽宁中医杂志,2014,41(9):1903-1905.
[39] 张 洁.七味白术散合补阳还五汤治疗肥胖2型糖尿病及改善胰岛素抵抗研究[J].陕西中医,2018,39(7):919-921.
[40] 倪 青,杜立娟,孟 祥,等.半夏泻心汤对初诊2型糖尿患者血浆GLP-1的影响初探[J].北京中医药,2017,67(6):549-551.
[41] 蔡春沉,王洪玺,王 肃.地黄多糖对肥胖糖尿病大鼠模型的治疗作用及对血清中GLP-1、GIP水平的影响[J].中国老年学杂志,2013,33(18):4506-4507.
[42] 魏世超,徐丽君,邹 欣,等.黄连有效成分及其组合物对荷糖小鼠胰岛素和胰高血糖素样肽1(GLP-1)分泌影响的初步研究[J].中国医院药学杂志,2017,37(14):1343-1347.
[43] 江 红,段滨红,杜馥曼,等.黄芪对糖尿病大鼠血清GLP-1及TNF-α、IL-18的影响[J].中国中医急症,2014,23(5):801-803.
[44] Guo C,Zhang C,Li L,et al.Hypoglycemic and hypolipidemic effects of oxymatrine in high-fat diet and streptozotocin-induced diabetic rats[J].Phytomedicine,2014,21(6):807-814.
[45] Santiago GP,Lopez MG.Agavins from Agave angustifolia and Agave potatorum affect food intake,body weight gain and satiety-related hormones(GLP-1 and ghrelin)in mice[J].Food Funct,2014,5(12):3311-3319.
[46] Casanova MA,Serrano J,Portune KJ,et al.Grape seed proanthocyanidins influence gut microbiota and enteroendocrine secretions in female rats[J].Food & Function,2018,9(3):1672-1682.
[47] Shin M,Choi E,Kim K,et al.Hexane fractions of bupleurum falcatum L.stimulates glucagon-like Peptide-1 secretion through Gβγ -Mediated pathway[J].Evidence-Based Complementary and Alternative Medicine,2014,2014(982165):1-8.
[48] Mangan AM,Al NW,Mcnamara N,et al.Effect of macronutrient type and gastrointestinal release site on PYY response in normal healthy subjects[J].J Clin Endocrinol Metab,2019,104(9):3661-3669.
[49] Lin N,Cai D,Jin D,et al.Ginseng panaxoside rb1 reduces body weight in diet-induced obese mice[J].Cell Biochemistry and Biophysics,2014,68(1):189-194.

相似文献/References:

[1]赵 倩,闻新丽△,段盛蕾,等.轻身消脂汤联合穴位埋线治疗脾虚湿阻型单纯性肥胖临床研究*[J].陕西中医,2019,(6):796.
[2]李海霞,史秀英,王璀瑛,等.益肾化痰方治疗肥胖型多囊卵巢综合征不孕临床研究[J].陕西中医,2019,(7):839.
　LI Haixia,SHI Xiuying,WANG Cuiying,et al.Clinical study of Yishen Huatan decoction in the treatment of obese polycystic ovarian syndrome infertility[J].,2019,(2):839.
[3]方泽彬,张曼怡,王高祥,等.李惠林论治肥胖型代谢综合征经验[J].陕西中医,2023,(3):367.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.023]
[4]杨小雪,王红丽,蔡芳英,等.名中医李惠林从三焦伏邪论治肥胖2型糖尿病经验采撷[J].陕西中医,2023,(10):1439.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.024]
　YANG Xiaoxue,WANG Hongli,CAI Fangying,et al.Li Huilin's experience in treating obesity type 2 diabetes from triple energizers latent qi[J].,2023,(2):1439.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.024]
[5]彭华容,王 茜,廖 波,等.三七参芪汤对冠心病患者肥胖且低密度脂蛋白胆固醇未达标的干预价值研究[J].陕西中医,2024,(10):1369.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.016]
　PENG Huarong,WANG Qian,LIAO Bo,et al.Clinical observation of Sanqi Shenqi decoction in the intervention of substandard low-density lipoprotein cholesterol in obese patients with coronary heart disease[J].,2024,(2):1369.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.016]

备注/Memo

备注/Memo:
*国家自然科学基金资助面上项目(81774237)；上海市科委中医引导项目(17401935200)；上海市卫生和计划生育委员会中医药科研专项课题(2016LQ018)；上海中医药大学科创课题
更新日期/Last Update: 2020-03-31