[1]段俞伽,崔 硕,刘 旭.参芪降糖颗粒联合迈之灵治疗非增殖期2型糖尿病视网膜病变气阴两虚、络脉瘀阻证疗效研究*[J].陕西中医,2020,(3):334-337.
　DUAN Yujia,CUI Shuo,LIU Xu..Effect of Shenqi Jiangtang granule combined with Maizhiling in treating non-proliferative 2 type diabetic retinopathy with syndrome of deficiency of both Qi and Yin and obstruction of collaterals[J].,2020,(3):334-337.
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参芪降糖颗粒联合迈之灵治疗非增殖期2型糖尿病视网膜病变气阴两虚、络脉瘀阻证疗效研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年3期
页码:
334-337
栏目:
临床研究
出版日期:
2020-03-05

文章信息/Info

Title:
Effect of Shenqi Jiangtang granule combined with Maizhiling in treating non-proliferative 2 type diabetic retinopathy with syndrome of deficiency of both Qi and Yin and obstruction of collaterals
文章编号:
DOI:10.3969/j.issn.10007369.2020.03.018
作者:
段俞伽; 崔 硕; 刘 旭
河北省廊坊市人民医院(廊坊 065000)
Author(s):
DUAN Yujia; CUI Shuo; LIU Xu.
The People's Hospital of Langfang City in Hebei Province(Langfang 065000)
关键词:
糖尿病视网膜病变;  参芪降糖颗粒;  迈之灵;  气阴两虚;  络脉瘀阻证
Keywords:
Diabetic retinopathy;  Shenqi Jiangtang granule;  Maizhiling;  Syndrome of deficiency of both Qi and Yin and obstruction of collaterals
分类号:
R587.1
文献标志码:
A
摘要:
目的:探讨参芪降糖颗粒联合迈之灵治疗非增殖期2型糖尿病视网膜病变气阴两虚、络脉瘀阻证的临床疗效。方法:选取收治的非增生期2型糖尿病视网膜病变患者86例,按随机数字表法分为观察组和对照组,每组43例。两组参照指南给予常规治疗措施; 对照组给予迈之灵片; 观察组在对照组治疗基础上给予参芪降糖颗粒。两组连续治疗12周。比较两组患者的视力、眼压、眼底检查、临床疗效以及气阴两虚、络脉瘀阻证症状评分。结果:治疗后,观察组(1.08±0.18)患者视力高于对照组(0.96±0.15)(P<0.01)。治疗后两组眼压[(14.19±2.57)mmHg 、(13.98±2.71)mmHg]差异无统计学意义(P>0.05)。观察组患者治疗后血管渗漏面积(0.49±0.06)cm2、微血管瘤个数(14.31±1.81)个、毛细血管无灌注区面积(0.52±0.07)cm2明显少于对照组[(0.67±0.09)cm2,(15.81±2.09)个,(0.67±0.09)cm2],视网膜循环时间(14.65±1.90)s显著短于对照组(15.90±2.13)s(P<0.01)。观察组的总有效率为90.70%,高于对照组的总有效率69.77%(P<0.05)。治疗后,观察组患者的气阴两虚、络脉瘀阻证症状评分显著低于对照组(P<0.01)。结论:参芪降糖颗粒联合迈之灵治疗非增殖期2型糖尿病视网膜病变气阴两虚、络脉瘀阻证可提高患者的视力,改善眼底病变和中医证候,提高临床疗效。
Abstract:
Objective:To investigate the efficacy of Shenqi Jiangtang granule combined with Maizhiling in treating non-proliferative 2 type diabetic retinopathy with syndrome of deficiency of both Qi and Yin and obstruction of collaterals.Methods:Eighty-six non-proliferative diabetic retinopathy patients admitted to the hospital from February of 2017 to April of 2019 were selected and divided into observation group and control group(43 patients in each group)according to the random number table.Both groups were given with conventional treatment with reference to the guidelines.The control group was given with Maizhiling tablets.On the basis of treatment in the control group,the observation group was orally given with Shenqi Jiangtang granule.Both groups were continuously treated for 12 weeks.The visual acuity,intraocular pressure,fundus examination,clinical efficacy,scores of synptoms of syndrome of deficiency of both Qi and Yin and obstruction of collaterals were compared between the two groups.Results:After treatment,the visual acuity(1.08±0.18)of the observation group was higher than that of the control group(0.96±0.15)(P<0.01).There was no significant difference in intraocular pressure between the two groups[(14.19±2.57)mmHg vs(13.98±2.71)mmHg] after treatment(P>0.05).After treatment,the area of vascular leakage(0.49±0.06)cm2,the number of microhemangiomas(14.31±1.81)caseand the area of capillary non-perfusion zone(0.52±0.07)cm2 in the observation group were significantly less than that in the control group[(0.67±0.09)cm2,( 15.81±2.09)case,( 0.67±0.09)cm2],and the retinal circulation time(14.65±1.90)s was significantly shorter than that in the control group(15.90±2.13)s(P<0.01).The total effective rate of the observation group was 90.70%,higher than that of the control group(69.77%)(P<0.05).After treatment,the scores of symptom of syndrome of deficiency of both Qi and Yin and obstruction of collaterals in the observation group were significantly lower than those in the control group(P<0.01).Conclusion:Shenqi Jiangtang granule combined with Maizhiling in treating non-proliferative 2 type diabetic retinopathy with syndrome of deficiency of both Qi and Yin and obstruction of collaterals can increase patients'eyesight,improve fundus lesions and traditional Chinese medicin syndromes,and improve clinical efficacy.

参考文献/References:

[1] 袁 娟,张 松.FCP、ACR、CRP与糖尿病视网膜病变严重程度关系的研究[J].陕西医学杂志,2017,46(8):1065-1066,1092.
[2] 杜战国.生蒲黄汤治疗非增殖型糖尿病视网膜病变临床研究[J].陕西中医,2018,39(7):897-899.
[3] 刘雅慧,张 兰.中医药治疗糖尿病视网膜病变研究进展[J].国际中医中药杂志,2017,39(6):567-569.
[4] 张 梅,李春霞,薛冰冰,等.益气养阴经验方对非增殖性糖尿病视网膜病变的视觉电生理的影响[J].中国中医眼科杂志,2019,29(3):184-187,196.
[5] 李红君,陈光华,李文东,等.参芪降糖颗粒联合吡格列酮治疗2型糖尿病的临床研究[J].现代药物与临床,2018,33(12):3242-3245.
[6] 中华医学会眼科学会眼底病学组.我国糖尿病视网膜病变临床诊疗指南(2014年)[J].中华眼科杂志,2014,50(11):851-865.
[7] 中华中医药学会.糖尿病视网膜病变中医防治指南[J].中国中医药现代远程教育,2011,9(4):154-155.
[8] 中华医学会糖尿病学分会.中国2 型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,22(8):2-42.
[9] 国家中医药管理局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:312-316.
[10] 黄梦哲.活血化瘀通络法治疗血络瘀阻证非增殖期2型糖尿病视网膜病变疗效观察[J].现代中西医结合杂志,2018,27(21):2289-2292,2295.
[11] 高 玮,陆 骏,秦 瑜,等.益气养阴经验方治疗非增生型糖尿病视网膜病变的临床研究[J].中国中医眼科杂志,2017,27(4):236-239.
[12] 李高彪,周云云,李雨薇,等.雷晓琴运用化瘀通络法辨治糖尿病视网膜病变经验[J].辽宁中医杂志,2017,44(12):2498-2500.
[13] 关小荣,董永孝,刘 萱,等.迈之灵片联合卵磷脂络合碘片治疗中心性浆液性脉络膜视网膜病变的疗效观察[J].现代药物与临床,2016,31(8):1253-1255.
[14] 段惠静,顾灵玲,马淑凤,等.迈之灵治疗非增殖期糖尿病视网膜血管病变的应用观察[J].航空航天医学杂志,2014,25(5):701-702.
[15] 薛光辉,陈思慧,李丽静,等.参芪降糖颗粒治疗2型糖尿病的Meta分析[J].西北药学杂志,2019,34(2):276-279.
[16] 陈丽丽.参芪降糖颗粒联合甲钴胺片治疗气阴两虚型DPN[J].安徽卫生职业技术学院学报,2017,16(5):65-66.

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备注/Memo

备注/Memo:
*河北省卫生和计划生育委员会科研项目(2017B00242)
更新日期/Last Update: 2020-04-07