[1]张灵利,何艳杰,李 红.幽门螺旋杆菌相关胃病不同中医证候患者胃黏膜MMP-2、TIMP-1的表达及临床意义*[J].陕西中医,2020,(3):353-356.
　ZHANG Lingli,HE Yanjie,LI Hong..Expression and clinical significance of MMP-2 and TIMP-1 in patients of HP-related gastropathy with different TCM syndromes[J].,2020,(3):353-356.
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幽门螺旋杆菌相关胃病不同中医证候患者胃黏膜MMP-2、TIMP-1的表达及临床意义*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年3期
页码:
353-356
栏目:
临床研究
出版日期:
2020-03-05

文章信息/Info

Title:
Expression and clinical significance of MMP-2 and TIMP-1 in patients of HP-related gastropathy with different TCM syndromes
文章编号:
DOI:10.3969/j.issn.10007369.2020.03.023
作者:
张灵利1; 何艳杰1; 李 红2
1.辽宁省朝阳市中心医院(朝阳 120000); 2.辽宁中医药大学附属医院消化内科(沈阳 110032)
Author(s):
ZHANG Lingli; HE Yanjie; LI Hong.
Chaoyang Central Hospital in Liaoning Province(Chaoyang 120000)
关键词:
幽门螺旋杆菌相关胃病;  中医证候;  基质金属蛋白酶-2;  基质金属蛋白酶抑制物-1;  胃黏膜
Keywords:
HP-related gastropathy;  TCM syndrome;  MMP-2;  TIMP-1;  Gastric mucosa
分类号:
R573
文献标志码:
A
摘要:
目的:探讨幽门螺旋杆菌(HP)相关胃病不同中医证候患者胃黏膜基质金属蛋白酶-2(MMP-2)及基质金属蛋白酶抑制物-1(TIMP-1)表达水平及其临床意义。方法:选取HP相关胃病患者58例为研究对象,根据中医证候不同分为脾胃湿热证组(n=23)、脾胃不和证组(n=18)和肝胃不和证组(n=17)。另选取同期来本院体检的健康志愿者20例作为对照组。比较不同疾病组HP感染率,不同疾病组和对照组胃黏膜炎症程度、MMP-2和TIMP-1表达水平,分析MMP-2和TIMP-1表达水平与HP感染、胃黏膜炎症程度的关系。结果:不同中医证型患者HP感染率比较,差异无统计学意义(P>0.05)。胃黏膜炎症反应程度:肝胃不和证组>脾胃不和证组>脾胃湿热证组>对照组,差异有统计学意义(P<0.05); 各组间胃黏膜MMP-2表达水平比较,差异无统计学意义(P>0.05)。TIMP-1表达水平:脾胃不和证组>肝胃不和证组>脾胃湿热证组>对照组,差异有统计学意义(P<0.05)。MMP-2表达水平与HP感染无明显相关性(r=-0.085,P>0.05),与胃黏膜炎症反应程度呈负相关(r=-0.201,P<0.05)。TIMP-1表达水平与HP感染呈正相关(r=0.182,P<0.05),与胃黏膜炎症反应程度呈正相关(r=0.268,P<0.05)。结论:HP相关胃病不同中医证候患者发病机制可能与胃黏膜MMP-2、TIMP-1平衡紊乱有关,不同中医证候患者胃黏膜TIMP-1表达有所差异。
Abstract:
Objective:To investigate the expression level of matrix metalloproteinase-2(MMP-2)and tissue inhibitor of metalloproteinases-1(TIMP-1)in gastric mucosa of patients with different TCM syndromes of helicobacter pylori(HP)-related gastropathy and their clinical significance.Methods:A total of 58 patients with HP-related gastropathy were selected as objectes and divided into three groupsspleen and stomach dampness-heat group(n=23),spleen-stomach disharmony syndrome group(n=18)and liver-stomach disharmony syndrome group(n=17).Another 20 healthy volunteers who came to our hospital for physical examination in the same period were selected as the control group.The infection rate of HP in different disease groups,the degree of gastric mucosal inflammation and the expression of MMP-2 and TIMP-1 in gastric mucosa of different disease groups and control groups were compared,and the relationship between the expression of MMP-2 and TIMP-1 and HP infection and the degree of gastric mucosal inflammation was analyzed.Results:There was no significant difference in HP infection rate among patients with different TCM syndrome types(P>0.05).The degree of gastric mucosal inflammationliver-stomach disharmony syndrome group > spleen-stomach disharmony syndrome group > spleen-stomach damp-heat syndrome group > control group,and the difference was statistically significant(P < 0.05).No significant difference was found in the expression of MMP-2 in gastric mucosa among the three groups(P>0.05).TIMP-1 expression levelspleen-stomach disharmony syndrome group > liver-stomach disharmony syndrome group > spleen-stomach damp-heat syndrome group > control group,and the difference was statistically significant(P<0.05).There was no significant correlation between the expression of MMP-2 and HP infection(r=-0.085,P>0.05),but there was a negative correlation between the expression level and the degree of gastric mucosal inflammation(r=-0.201,P<0.05).The expression of TIMP-1 was positively correlated with HP infection(r=0.182,P<0.05)and the degree of gastric mucosal inflammation(r=0.268,P<0.05).Conclusion:The pathogenesis of patients with different TCM syndromes of HP-related gastropathy may be related to the imbalance of MMP-2 and TIMP-1 in gastric mucosa,and the expression of TIMP-1 in gastric mucosa is different in patients with different TCM syndromes.

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备注/Memo

备注/Memo:
*辽宁省科学技术基金资助项目(2016028768)
更新日期/Last Update: 2020-04-07