[1]王艳威,季 杰,巩子汉,等.半夏泻心汤加减治疗慢性萎缩性胃炎脾胃湿热证临床研究*[J].陕西中医,2020,(4):500-501,537.
　WANG Yanwei,JI Jie,GONG Zihan,et al.Clinical efficacy and safety evaluation of Banxia Xiexin decoction in the treatment of chronic atrophic gastritis of spleen-stomach damp-heat type[J].,2020,(4):500-501,537.
点击复制

半夏泻心汤加减治疗慢性萎缩性胃炎脾胃湿热证临床研究*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年4期
页码:
500-501,537
栏目:
临床研究
出版日期:
2020-04-05

文章信息/Info

Title:
Clinical efficacy and safety evaluation of Banxia Xiexin decoction in the treatment of chronic atrophic gastritis of spleen-stomach damp-heat type
文章编号:
DOI:10.3969/j.issn.10007369.2020.04.029
作者:
王艳威1; 季 杰2; 巩子汉3; 孙学东1
1.北京市隆福医院中医科(北京100010); 2.清华大学附属玉泉医院中医科(北京100049); 3.甘肃中医药大学(兰州730050)
Author(s):
WANG Yanwei; JI Jie; GONG Zihan; et al.
Department of Traditional Chinese Medicine,Longfu Hospital in Beijing(Beijing 100010)
关键词:
半夏泻心汤;  脾胃湿热证;  慢性萎缩性胃炎;  免疫功能;  炎性反应;  安全性
Keywords:
Banxia Xiexin decoction;  Spleen-stomach damp-heat type;  Chronic atrophic gastritis;  Immune function;  Inflammatory response;  Safety
分类号:
R573.32
文献标志码:
A
摘要:
目的:评价半夏泻心汤加减治疗脾胃湿热证慢性萎缩性胃炎的临床疗效及安全性。方法: 将100例脾胃湿热证慢性萎缩性胃炎患者,按照随机数字表法分为观察组和对照组各50例。比较两组患者研究前后主要中医证候积分、血清指标变化(IL-2、IL-6、G-17、ET、EGF)、证候临床疗效、HP清除率及不良反应发生率。 结果: 两组患者在治疗12周后主要中医证候积分均有所下降,观察组治疗后证候积分明显低于对照组; 两组患者治疗后胃泌素G-17较前明显升高,且观察组明显高于对照组; IL-2及IL-6、EGF、ET均较前明显降低,且观察组明显低于对照组; 比较证候临床疗效,对照组总有效率为72.0%,观察组总有效率为88.0%,观察组证候临床疗效明显优于对照组; 以上差异均有统计学意义(P<0.05)。观察组有89.1%患者HP转阴,对照组为77.3%,观察组HP清除率较对照组高; 观察组不良反应发生率为2.0%,对照组为6.0%; 以上差异均无统计学意义(P>0.05)。结论: 半夏泻心汤可提高脾胃湿热证CAG患者机体免疫功能,改善胃黏膜炎性反应,并改善患者的临床证候。
Abstract:
Objective:To evaluate the clinical efficacy and safety of Banxia xiexin decoction in the treatment of chronic atrophic gastritis of spleen-stomach damp-heat type.Methods:100 patients with chronic atrophic gastritis of spleen-stomach damp-heat type of our hospital were divided into observation group and control group with 50 cases each according to the random number table method.Before and after the study,the changes of main TCM syndrome score,serum indexes(IL-2,IL-6,G-17,ET,EGF),clinical efficacy of syndrome,clearance rate of HP and incidence of adverse reactions were compared between the two groups.Results: After 12 weeks of treatment,the main TCM syndrome scores of the two groups were decreased,and the syndrome scores of the observation group were significantly lower than that of the control group; After treatment,gastrin G-17 were significantly higher in the observation group than in the control group; IL-2,IL-6,EGF and ET were significantly lower in the observation group than in the control group; The total effective rate was 72.0% in the control group and 88.0% in the observation group.The clinical efficacy of the observation group was significantly better than that of the control group.The above differences were statistically significant(P<0.05).89.1% of the patients in the observation group turned negative,while in the control group was 77.3%.The clearance rate of HP in the observation group was higher than that in the control group; The incidence of adverse reactions was 2.0% in the observation group and 6.0% in the control group.The above differences were not statistically significant(P>0.05).Conclusion:Banxia Xiexin decoction can improve the immune function of CAG patients of spleen-stomach damp-heat type,improve the gastric mucositis reaction and improve the clinical syndrome of CAG patients.

参考文献/References:

[1] 中国中西医结合学会消化系统疾病专业委员会.慢性萎缩性胃炎中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2018,26(2):121-131.
[2] 李 娜,杨 康.中医药治疗慢性萎缩性胃炎的研究进展[J].湖北中医杂志,2015,37(2):76-78.
[3] 孙明明,李 聪,史 林.王庆国教授对慢性萎缩性胃炎的治疗经验探析[J].陕西中医,2019,40(2):260-263.
[4] 韩宇斌,陈锦锋,邓健敏,等.胃肠安片治疗脾胃湿热型化生萎缩性胃炎的临床观察[J].齐齐哈尔医学院学报,2016,37(20):2512-2514.
[5] 郭志刚.加味半夏泻心汤对慢性萎缩性胃炎(CAG)脾胃湿热证的临床观察[J].中医临床研究,2017,9(35):83-85.
[6] Guo Z.The effect of Chinese herbal medicine Banxia Baizhu Tianma decoction for thetreatment of vertebrobasilar insufficiency vertigo:a systematic review and meta-analysis ofrandomized controlled trials[J].Complementary Therapies in Medicine,2017,31:27-38.
[7] 李慧臻,刘 琳,刘华一,等.半夏泻心汤对PLGC大鼠胃黏膜组织病理学及HP的影响研究[J].中国中西医结合消化杂志,2017,25(1):35-39.
[8] 刘洪周.半夏泻心汤加减治疗脾虚胃热型慢性胃炎的疗效分析[J].陕西中医,2016,37(8):949-950.
[9] 门凯龙,黄海量,孙倩倩,等.半夏泻心汤加减方治疗Hp阳性慢性萎缩性胃炎疗效及安全性系统评价[J].山东中医杂志,2019,38(9):833-838.
[10] 李 多,王 锐,于永强,等.雷贝拉唑、阿莫西林、克拉霉素联合枳术宽中胶囊治疗老年幽门螺杆菌阳性慢性萎缩性胃炎[J].山东医药,2018,58(3):78-80.
[11] 王金春,张海莲,刘军权,等.Hp感染胃黏膜IL-17、TLR2及PD-1表达及意义[J].徐州医科大学学报,2017,37(10):636-641.
[12] 杨贵珍,郑月娟,姜 昕,等.半夏泻心汤抑制巨噬细胞分泌促炎因子抗胃炎机制研究[J].中国中西医结合消化杂志,2015,23(3):160-164.
[13] 高 洁.胃蛋白酶原、胃泌素-17在慢性萎缩性胃炎中的表达及其与幽门螺杆菌感染相关性分析[J].陕西医学杂志,2019,48(1):131-134.
[14] 彭雪靖,刘 洁.半夏泻心汤对PLGC大鼠胃黏膜P13k/Akt/mTOR通路的影响及其防治研究[J].湖南中医杂志,2018,34(10):155-157.
[15] 符娇文,韩 平,符贵超.半夏泻心汤对胃癌前病变大鼠胃黏膜中B细胞淋巴瘤-2与表皮生长因子受体表达影响[J].四川中医,2018,36(12):50-53.

备注/Memo

备注/Memo:
*国家自然科学基金资助项目(81670112)；北京市卫生科技计划项目[卫计研-(2018)-7]
更新日期/Last Update: 2020-04-13