[1]何 锐,曹情雯,赵苗苗,等.基于数据挖掘解析治疗新型冠状病毒肺炎中药院内制剂的组方规律*[J].陕西中医,2020,(8):1011-1015.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.001]
　HE Rui,CAO Qingwen,ZHAO Miaomiao,et al.Based on data mining to analyze the prescription rules of in-hospital preparation of traditional Chinese medicine for the treatment of new corona virus pneumonia[J].,2020,(8):1011-1015.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.001]
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基于数据挖掘解析治疗新型冠状病毒肺炎中药院内制剂的组方规律*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年8期
页码:
1011-1015
栏目:
“新型冠状病毒肺炎”专题
出版日期:
2020-08-05

文章信息/Info

Title:
Based on data mining to analyze the prescription rules of in-hospital preparation of traditional Chinese medicine for the treatment of new corona virus pneumonia
作者:
何 锐1; 曹情雯2; 赵苗苗3; 王海芳1; 轩 晨4; 成 雅1; 曹 语1; 李娟娥5; 袁瑞华1△
1.陕西中医药大学(咸阳 712046); 2.陕西省中医医院(西安 710003); 3.陕西中医药大学第二附属医院重症医学科(咸阳712046); 4.重庆医科大学中医药学院(重庆 400016); 5.陕西省人民医院中医科(西安 710068)
Author(s):
HE Rui; CAO Qingwen; ZHAO Miaomiao; et al.
Shaanxi University of Traditional Chinese Medicine(Xianyang 712046)
关键词:
新型冠状病毒肺炎;  数据挖掘;  院内中药制剂;  用药特点;  疫病;  组方规律
Keywords:
COVID-19 pneumonia;  Data mining;  In-hospital preparations of traditional Chinese medicine;  Drug used characteristics;  Pestilence;  Prescription-formulating principle
分类号:
R563.1
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.001
文献标志码:
A
摘要:
目的:收集部分省市治疗新型冠状病毒肺炎中药院内制剂配方,使用中医传承辅助平台(V2.5)数据挖掘软件进行分析,总结防治新冠肺炎用药规律及特点,以期得出潜在新方。方法:全面检索各省(自治区、直辖市)药品监督管理局网站、各医院官方微信公众号(网站),收集经省级药品监督管理部门备案批准的可用于新型冠状病毒肺炎治疗的医院中药制剂,得到宁夏回族自治区等有具体药物组成的中药院内制剂21种,对纳入方药应用频次分布统计、关联规则以及基于熵聚类方法规则分析等方法进行组方用药规律的分析。结果:纳入的21首中药院内制剂配方,共包含90味中药,其中药物使用频次方面,茯苓、杏仁、藿香等药物较高; 药物性味以辛、温为主,归肺、脾、胃经药物最多,处方中化湿类药物应用最广泛; 得到陈皮-甘草、白术-茯苓、藿香-茯苓等15对常见药物组合; 潜在新方的配伍思路以宣清并用,寒温并调为核心。结论:各地区治疗新型冠状病毒肺炎中药院内制剂多使用化湿药物,多从肺、脾、胃入手,切合了新型冠状病毒肺炎的早期病机。
Abstract:
Objective:To analyze the TCM(traditional Chinese medicine)hospital preparations for the treatment of COVID-19 based on TCM inheritance support system(V2.5),summarize their medication characteristics and hope to get potential new prescriptions.Methods:Retrieve the official websites and WeChat websites to collect in-hospital preparations of Traditional Chinese Medicine(TCM)approved by the provincial food and drug supervision bureaus for the treatment of COVID-19 pneumonia.Frequency statistics,association rules,law analysis based on entropy clustering methods were used to mine the characteristics of these preparations.Results:A total of 21 prescriptions composed of 90 medicines were analyzed,of which the most frequently used medicines are Poria and Almonds.The drugs are mostly acrid and warm,which belong to the lung,spleen and stomach channels,and dampness-eliminating medicines are the most frequently used.Fifteen pairs of common drug combinations such as tangerine peel licorice,Atractylodes macrocephala Poria and Huoxiang Poria were analyzed.The combination of dispersing and clearing away heat,therapy combined cooling and warming are the core of the thinking of potential new prescription.Conclusion:Based on analysis,Dampness-eliminating medicines and medicines distributing to the lung,spleen and stomach channels are frequently used in the in-hospital preparations,which is suitable for the prevention and treatment of early symptoms of pneumonia.

参考文献/References:

[1] Hui DS,I Azhar E,Madani TA,et al.The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health-the latest 2019 novel coronavirus outbreak in Wuhan,China[J].Int J Infect Dis,2020,91:264-266.
[2] 新京报.国际病毒分类委员会将新型冠状病毒命名为 SARS-CoV-2[EB/OL].(2020-02-12)[2020-04-18].http://www.chinanews.com/gj/2020/02-12/9088314.shtml.
[3] 国家卫生健康委员会.关于印发新型冠状病毒肺炎诊疗方案(试行第七版)的通知[EB/OL].(2020-03-03)[2020-04-18].http://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml.
[4] 贾 谦,陈永杰,陈光曼,等.确立中医药战略地位的重要意义[J].中国工程科学,2004,6(7):4-13.
[5] 国务院新闻办.国新办举行发布会:余艳红介绍中医药在参与新冠肺炎疫情防控和救治中发挥重要作用[EB/OL].(2020-03-27)[2020-04-18].http://ghs.satcm.gov.cn/gongzuodongtai/2020-03-27/14281.html.
[6] 夏 杰,尹蔚萍,张文荫.发展中医医院中药制剂的思考[J].中医药管理杂志,2014,22(9):1523-1527.
[7] 中国医药报.国家药监局:科学有序精准开展新冠肺炎防控药品应急审批工作[EB/OL].(2020-02-22)[2020-04-18].http://www.nmpa.gov.cn/WS04/CL2056/375027.h tml.
[8] 卢 朋,李 健,唐仕欢,等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志,2012,18(9):1-4.
[9] 杨洪军,唐仕欢,卢 朋.中医传承辅助平台的开发与应用 [M].福州:福建科学技术出版社,2013:47-49.
[10] 仝小林,李修洋,赵林华,等.从“寒湿疫”角度探讨新型冠状病毒肺炎的中医药防治策略[J].中医杂志,2020,61(6):465-470,553.
[11] 苗 青,丛晓东,王 冰,等.新型冠状病毒肺炎的中医认识与思考[J].中医杂志,2020,61(4):286-288.
[12] 田合禄,李正富.五运六气解读新型冠状病毒肺炎[J].浙江中医药大学学报,2020,44(3):211-215,222.
[13] 杨道文,李得民,晁恩祥,等.关于新型冠状病毒肺炎中医病因病机的思考[J].中医杂志,2020,61(7):557-560.
[14] 谢铱子,纪树亮,钟彩婷,等.藿朴夏苓汤治疗新型冠状病毒肺炎的网络药理学分子机制研究[J/OL].中药材,2020,43(5):1284-1294(2020-03-20)[2020-04-18].https://kns.cnki.net/KCMS/detail/44.1286.r.2020052 9.1308.047.html.
[15] 秦一冰,曲妮妮,郑 忻,等.基于网络药理学探讨柴胡-黄芩治疗新型冠状病毒肺炎的作用机制[J/OL].中华中医药学刊,2020,39:1-12(2020-03-27)[2020-04-18].https://kns.cnki.net/KCMS/detail/21.1546.R.2020032 6.1521.002.html.
[16] 王 佳,冯星火,国丽娜,等.银翘散对流感病毒感染性重症肺炎小鼠肺组织的修复机制研究[J].陕西中医,2020,41(2):156-159.

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备注/Memo

备注/Memo:
*陕西省中医药管理局资助项目(2019-WT003)
更新日期/Last Update: 2020-08-10