[1]陈俊臣,任晓乐,李 倩,等.解痉汤治疗动脉瘤性蛛网膜下腔出血后脑血管痉挛临床研究*[J].陕西中医,2020,(8):1055-1058.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.010]
　CHEN Junchen,REN Xiaole,LI Qian,et al.Jiejing decoction on von willebrand factor and endothelin levels in cerebral vasospasm patients after aneurysmal subarachnoid hemorrhage[J].,2020,(8):1055-1058.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.010]
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解痉汤治疗动脉瘤性蛛网膜下腔出血后脑血管痉挛临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年8期
页码:
1055-1058
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Jiejing decoction on von willebrand factor and endothelin levels in cerebral vasospasm patients after aneurysmal subarachnoid hemorrhage
作者:
陈俊臣1; 任晓乐2; 李 倩1; 张 丹1; 高 燕1; 梁应凤1; 宋 卜1; 郭姗姗1△; Ken Takasaki3
1.解放军火箭军特色医学中心(北京100088); 2.军委联合参谋部警卫局卫生保健处(北京 100017); 3.日本东京女子医科大学肝胆外科(东京163-8001)
Author(s):
CHEN Junchen; REN Xiaole; LI Qian; et al.
The PLA Rocket Force Characteristic Medical Center(Beijing 100088)
关键词:
解痉汤;  动脉瘤性蛛网膜下腔出血;  脑血管痉挛;  血管性血友病因子;  内皮素;  大脑中动脉平均流速
Keywords:
Jiejing decoction;  Aneurysmal subarachnoid hemorrhage;  Cerebral vasospasm;  Von willebrand factor;  Endothelin;  MCA-Vm
分类号:
R743.35
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.010
文献标志码:
A
摘要:
目的:探讨中药解痉汤对动脉瘤性蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)患者血管性血友病因子(vWF)和内皮素水平的影响。方法:纳入继发性动脉瘤性SAH后CVS患者74例,随机分为对照组(36例)和治疗组(38例)。对照组采用西药治疗,治疗组在对照组基础上同时口服解痉汤。vWF定量分析基于酶联免疫吸附测定(ELISA)检测; 内皮素检测采用放射免疫分析。采用Fisher分级法判断患者脑出血情况及TCD检查衡量CVS程度。结果:治疗后两组临床症状、Fisher分级、大脑中动脉平均流速(MCA-Vm)和颈内动脉颅外段平均流速(VICA-Vm)和Lindegaard指数均显著改善,vWF和内皮素均显著降低,治疗前后组间比较,差异具有统计学意义(P<0.05)。同时,组间治疗后比较发现,治疗组各指标的改善明显优于对照组,差异具有统计学意义(P<0.05)。且治疗组vWF浓度和内皮素含量与于脑血管痉挛程度相关性分析提示,二者水平与脑血管痉挛程度呈正相关(P<0.05)。结论:中药解痉汤可改善动脉瘤性SAH后CVS的临床症状、缓解颅内出血及血管痉挛、并降低vWF和内皮素水平进而改善患者血管内皮细胞功能。
Abstract:
Objective:To study the effect of traditional Chinese medicine Jiejing decoction on von willebrand factor(vWF)and endothelin levels in cerebral vasospasm(CVS)patients after aneurysmal subarachnoid hemorrhage(SAH).Methods:A total of 74 patients with CVS after aneurysmal subarachnoid hemorrhage were enrolled in the study.Included patients were randomly divided into western medicine treatment group(control group,36 cases)and Chinese and western medicine combined treatment group(experimental group,38 cases).On the basis of treatment in the control group,patients in the experimental group were treated with Jiejing decoction simultaneously.The quantitative analysis of vWF was based on enzyme linked immunosorbent assay(ELISA),and the radioimmunoassay was used to detect endothelin.Fisher grading method was used to judge the cerebral hemorrhage,and TCD was used to measure the CVS degree.Results:After treatment,the clinical symptoms,fisher classification,the mean velocity of the middle cerebral artery(MCA-Vm),the mean velocity of intracranial internal carotid artery(VICA-Vm)and lindegaard index of the two groups were significantly improved,vWF and endothelin were significantly reduced,and there was a significant difference between the two groups before and after treatment(P<0.05).Besides,it was found that the improvement of each index in the experimental group was significantly better than that in the control group,and the difference was statistically significant(P<0.05).Meanwhile,correlation analysis of vWF concentration and endothelin content with the degree of CVS in the experimental group showed that there was a positive correlation between the levels of the two indexes and the degree of CVS(P<0.05).Conclusion:Jiejing decoction can improve clinical symptoms,relieve intracranial hemorrhage and vasospasm,and reduce levels of vWF and endothelin to improve vascular endothelial cell function in patients with CVS after aneurysmal subarachnoid hemorrhage.

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备注/Memo

备注/Memo:
*军队医学科技青年培训计划孵化项目(18QNP031)
更新日期/Last Update: 2020-08-10