[1]戴朝博.养肝益水方治疗1级高血压疗效及对患者血压变异性的影响*[J].陕西中医,2020,(8):1062.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.012]
　DAI Chaobo.Yanggan Yishui recipe in the treatment of grade 1 hypertension and its effect on blood pressure variability[J].,2020,(8):1062.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.012]
点击复制

养肝益水方治疗1级高血压疗效及对患者血压变异性的影响*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年8期
页码:
1062
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Yanggan Yishui recipe in the treatment of grade 1 hypertension and its effect on blood pressure variability
作者:
戴朝博
武汉市第一医院老年病科(武汉 430022)
Author(s):
DAI Chaobo
Department of Geriatrics,Wuhan First Hospital(Wuhan 430022)
关键词:
养肝益水方;  1级高血压;  证候;  炎性因子;  血压变异性;  白介素-6
Keywords:
Yanggan Yishui recipe;  Grade 1 hypertension;  TCM syndrome;  Inflammatory factors;  Blood pressure variability;  IL-6
分类号:
R544.1
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.012
文献标志码:
A
摘要:
目的:探讨养肝益水方治疗1级高血压的疗效及对血压变异性的影响。方法:选取160例1级高血压病患者,按随机数字表法分为治疗组和对照组,每组各80例。对照组患者采用常规药物治疗,治疗组在对照组的基础上给予养肝益水方治疗。观察比较两组患者中医证候疗效,治疗前后炎性因子IL-6、TNF-α、CRP水平,治疗前后SBP、DBP及降压有效率,治疗前后血压变异性指标变化。结果:治疗组与对照组相比,中医症候治疗总有效率更高,治疗后患者血清炎性因子IL-6、TNF-α、CRP水平更低,SBP及DBP更低,降压治疗总有效率更高,SBP标准差、DBP标准差、SBP平均真实变异、DBP平均真实变异均更低,差异具有统计学意义(P<0.05)。结论:养肝益水方治疗对1级高血压治疗效果较好,能有效减轻患者炎性反应,缓解中医症候,降低患者血压,改善患者血压变异性。
Abstract:
Objective:To investigate the efficacy of Yanggan Yishui recipe in the treatment of grade 1 hypertension and its effect on blood pressure variability.Methods:160 patients with grade 1 hypertension were randomly divided into Yanggan Yishui decoction group(n=80)and routine treatment group(n=80).The routine treatment group were treated with routine drugs,and the Yanggan Yishui recipe treatment group were treated with Yanggan Yishui recipe on the basis of the routine treatment group.The curative effect of TCM syndrome,the levels of IL-6,TNF-α and CRP before and after treatment,the effective rate of systolic blood pressure,diastolic blood pressure and antihypertensive before and after treatment,and the changes of blood pressure variability indexes before and after treatment were observed and compared between the two groups.Results:Compared with the routine treatment group,the Yanggan Yishui recipe treatment group had higher total effective rate of TCM syndrome and antihypertensive treatment,but lower levels of serum inflammatory factors IL-6,TNF-α and CRP,the systolic blood pressure,diastolic blood pressure,the standard deviation of systolic blood pressure,the standard deviation of diastolic blood pressure,the average true variation of systolic blood pressure and the average true variation of diastolic blood pressure.The difference was statistically significant(P<0.05).Conclusion:Yanggan Yishui recipe is effective in the treatment of grade 1 hypertension,which can effectively reduce the inflammatory reaction of patients,alleviate TCM symptoms,reduce blood pressure and improve blood pressure variability,which is worth popularizing in clinical practice.

参考文献/References:

[1] 司小北,刘 蔚.高血压病患者血脂综合指标与大动脉僵硬度异常的相关性[J].中华疾病控制杂志,2019,23(8):956-959.
[2] 曲海燕,刘 杰,晏苏征.基于社区高血压病患病率的调查研究[J].公共卫生与预防医学,2014,25(4):98-100.
[3] 温改艳,袁 洪,舒婧娴,等.抗高血压药物的研究现状[J].中国临床药理学杂志,2017,33(24):2629-2632.
[4] 玄欣彤,蒋卫民.中医药治疗高血压前期的经验[J].中西医结合心脑血管病杂志,2018,16(11):1627-1629.
[5] 陈 婕,王肖龙,阮小芬,等.潜阳合剂干预高血压1级(阴虚阳亢型)病人的临床疗效[J].中西医结合心脑血管病杂志,2017,15(23):2945-2949.
[6] 孙 娜,辛 宝,郭亚收,等.高血压病患者中医体质类型与生活习惯相关性分析[J].国际中医中药杂志,2017,39(10):878-882.
[7] 雍苏南,谭元生.高血压病中医证型分布规律及合并病的相关性研究[J].辽宁中医杂志,2018,45(5):914-916.
[8] 张叶祥.周宜轩用养肝益水颗粒治疗原发性高血压早期肾损害经验探析[J].中西医结合心脑血管病杂志,2013,11(12):1520-1521.
[9] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011,3(7):42-93.
[10] 国家食品药品监督管理总局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:73-77.
[11] 薛文娟.心理康复对改善老年高血压合并焦虑抑郁患者负面情绪和生活质量的效果[J].中国健康心理学杂志,2019,27(5):693-696.
[12] 王 轶,张宗杰,陈宏朝.立体定向软通道微创治疗高血压脑出血43例[J].陕西医学杂志,2015,44(10):1425-1426.
[13] 杨 磊.血栓通注射液在高血压脑出血术后应用的临床观察[J].陕西中医,2015,36(1):58-59.
[14] 张 洋,何建成,黄品贤,等.原发性高血压中医证素分布及其与影响因素的相关性研究[J].中华中医药杂志,2017,32(12):5664-5668.
[15] 玄欣彤,蒋卫民.中医药治疗高血压前期的经验[J].中西医结合心脑血管病杂志,2018,16(11):1627-1629.
[16] 姜仁贺,张明雪.从肝论治冠心病合并高血压病探讨[J].世界中医药,2016,11(3):536-538.
[17] 许祖建,戴小华,汤丽芬.养肝益水颗粒对高血压病患者炎症因子的影响[J].实用中医药杂志,2013,29(8):612-614.
[18] 王 丽,高家荣,韩燕全,等.养肝益水颗粒成型工艺[J].中国实验方剂学杂志,2012,18(1):42-45.
[19] 王 波,戴小华,杨 帆,等.养肝益水颗粒对自发性高血压大鼠肾脏Smad2、Smad3、Smad7表达的影响[J].安徽中医学院学报,2011,30(5):59-62.
[20] 许祖建,戴小华,顾健霞.养肝益水颗粒对高血压病患者内皮功能的影响[J].中国中医急症,2012,21(2):182-184.
[21] 李伟萍,郑云海,王君华,等.养肝益水颗粒对高血压病早期肾损害的治疗效果及对血压变异性的影响[J].中华中医药学刊,2018,36(8):1917-1919.

备注/Memo

备注/Memo:
*武汉市卫生健康委员会科研基金资助项目(WX19D26)
更新日期/Last Update: 2020-08-10