[1]桂军明,朱守斌,张国旗,等.活血通络汤治疗痰瘀阻络型缺血性脑卒中临床研究*[J].陕西中医,2020,(8):1066.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.013]
　GUI Junming,ZHU Shoubin,ZHANG Guoqi,et al.Clinical efficacy of Huoxue Tongluo decoction in the treatment of ischemic stroke of phlegm-stasis blocking collateral type[J].,2020,(8):1066.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.013]
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活血通络汤治疗痰瘀阻络型缺血性脑卒中临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年8期
页码:
1066
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Clinical efficacy of Huoxue Tongluo decoction in the treatment of ischemic stroke of phlegm-stasis blocking collateral type
作者:
桂军明; 朱守斌; 张国旗; 江多范
安徽省淮南市新华医疗集团新华医院中西医结合科(淮南 232052)
Author(s):
GUI Junming; ZHU Shoubin; ZHANG Guoqi; et al.
Department of Integrated Traditional Chinese and Western Medicine,Xinhua Hospital,Xinhua Medical Group in Huainan City,Anhui Province(Huainan 232052)
关键词:
活血通络汤;  痰瘀阻络型;  缺血性脑卒中;  中医症候积分;  神经功能
Keywords:
Huoxue Tongluo decoction;  Phlegm-stasis blocking collateral type;  Ischemic stroke;  TCM syndrome score;  Neurological function
分类号:
R743
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.013
文献标志码:
A
摘要:
目的:探讨活血通络汤治疗痰瘀阻络型缺血性脑卒中的临床疗效和安全性。方法:选取82例痰瘀阻络型缺血性卒中患者作为研究对象,按照其治疗方法分为对照组40例和观察组42例,对照组予以常规西药治疗,观察组患者在对照组治疗基础上予以活血通络汤治疗,两组患者均治疗2周,治疗结束后比较两组患者临床疗效、中医症候积分、神经功能、日常生活能力、血液流变学指标水平及不良反应。结果:经治疗2周后,观察组患者临床治疗总有效率为97.62%,显著高于对照组临床总有效率82.50%(P<0.05); 两组患者治疗前中医症候积分、NIHSS及BI评分比较,差异无统计学意义,治疗后两组患者中医症候积分和NIHSS评分均较治疗前下降,而BI评分显著上升,但治疗后观察组患者中医症候积分和NIHSS评分下降和BI评分上升程度均显著高于对照组患者(P<0.05); 两组患者治疗前全血高切黏度、全血低切黏度、纤维蛋白原及血浆黏度水平比较,差异无统计学意义,治疗后两组患者全血高切黏度、全血低切黏度、纤维蛋白原及血浆黏度水平均较治疗前明显下降,但治疗后观察组患者血液流变学指标水平均低于对照组患者,差异有统计学意义(P<0.05); 两组患者均未出现不良事件。结论:活血通络汤可提高痰瘀阻络型缺血性脑卒中患者临床疗效,改善其症状体征、神经功能及血液状态,提高日常活动能力。
Abstract:
Objective:To explore the clinical efficacy and safety of Huoxue Tongluo decoction in the treatment of ischemic stroke of phlegm-stasis blocking collateral type.Method:82 patients with ischemic stroke of phlegm-stasis blocking collateral type were selected as the research objects.According to their treatments,they were divided into the control group,40 cases,and the observation group,42 cases.The patients in control group were treated with conventional western medicine.The patients in the observation group were supplemented with Huoxue Tongluo decoction.Patients in both groups were treated for 2 weeks.After treatment,the clinical efficacy,TCM syndrome score,neurological function,ability of daily living,hemorheology index and adverse reactions were compared between the two groups.Results:2 weeks after treatment,the total effective rate of clinical treatment in the observation group was 97.62%,which was significantly higher than the 82.50% in the control group(P<0.05).There was no difference in TCM symptom scores,NIHSS,and BI scores between the two groups before treatment.After treatment,the TCM symptom scores and NIHSS scores of the two groups were lower,and the BI score increased significantly.However,the degree of decreasing in TCM symptom score and NIHSS score,and increasing in BI score in the observation group after treatment were significantly higher than those in the control group(P<0.05).There was no difference in high blood viscosity,low blood viscosity,fibrinogen,and plasma viscosity between the two groups before treatment.After treatment,the levels of high blood viscosity,low blood viscosity,fibrinogen,and plasma viscosity of the two groups were significantly lower.However,the levels of all hemorheological indicators in the observation group were significantly lower than those in the control group after treatment(P<0.05).No adverse events occurred in either group.Conclusion:Huoxue Tongluo decoction can improve the clinical efficacy of patients with ischemic stroke of phlegm-stasis blocking collateral type,improve their symptoms and signs,nerve function and blood status,and improve their daily activities.

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备注/Memo

备注/Memo:
*国家重点研发计划-中医药现代化研究科研课题(2018YFC1704103)
更新日期/Last Update: 2020-08-10