[1]范 艳,管小青,许 钒△.养阴活血通络汤治疗类风湿性关节炎疗效及对患者关节液TNF-α、IL-1和PGE2的影响*[J].陕西中医,2020,(8):1098.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.022]
　FAN Yan,GUAN Xiaoqing,XU Fan..Effect of Yangyin Huoxue Tongluo decoction on TNF- α,IL-1 and PGE2 in the synovial fluid of patients with rheumatoid arthritis[J].,2020,(8):1098.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.022]
点击复制

养阴活血通络汤治疗类风湿性关节炎疗效及对患者关节液TNF-α、IL-1和PGE2的影响*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年8期
页码:
1098
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Effect of Yangyin Huoxue Tongluo decoction on TNF- α,IL-1 and PGE2 in the synovial fluid of patients with rheumatoid arthritis
作者:
范 艳1; 2; 管小青2; 许 钒1△
1.安徽中医药大学药学院(合肥230000); 2.皖南医学院第一附属医院(弋矶山医院)药学部(芜湖 241000)
Author(s):
FAN Yan; GUAN Xiaoqing;  XU Fan.
School of Pharmacy,Anhui University of Chinese Medical Medicine(Hefei 230000)
关键词:
养阴活血通络汤;  类风湿关节炎;  肿瘤坏死因子-α;  白细胞介素-1;  前列腺素E2
Keywords:
Yangyin Huoxue Tongluo decoction;  Rheumatoid arthritis;  TNF-α;  IL-1;  PGE2
分类号:
R684.3
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.022
文献标志码:
A
摘要:
目的: 探讨养阴活血通络汤治疗类风湿性关节炎的疗效及对患者关节液中TNF-α、IL-1、PGE2的影响。方法:选取类风湿性关节炎患者100例,随机分为对照组和观察组各50例。对照组采取西药治疗,观察组采取西药加养阴活血通络汤治疗。比较两组治疗前后关节液TNF-α、IL-1及PGE2水平,关节疼痛、关节肿胀及晨僵时间评分、临床疗效及生活质量情况。结果:治疗4、8、12周后,两组患者中医症状积分均明显下降,且观察组比对照组下降更明显(P<0.05)。治疗后,两组TNF-α、IL-1水平,关节疼痛、关节肿胀及晨僵时间评分均降低,PGE2水平均升高(P<0.05); 观察组治疗后TNF-α、IL-1水平,关节疼痛、关节肿胀及晨僵时间评分均低于对照组,PGE2水平高于对照组(P<0.05)。观察组治疗后生活质量明显优于对照组(P<0.05)。结论:养阴活血通络汤可显著缓解类风湿性关节炎患者关节疼痛、肿胀等症状,改善炎症及免疫水平,临床疗效满意,并可改善患者生活质量水平。
Abstract:
Objective:To explore the therapeutic effect of Yangyin Huoxue Tongluo decoction on rheumatoid arthritis and its effect on TNF-α,IL-1 and PGE2 in the joint fluid of patients.Methods:100 patients with rheumatoid arthritis were randomly divided into control group and observation group,each with 50 cases.The control group was treated with conventional western medicine,and the observation group was treated with Yangyin Huoxue Tongluo decoction on the basis of the control group.Results:After 1,2 and 4 courses of treatment,the TCM symptom scores of the two groups decreased significantly,and the observation group decreased more significantly than the control group(P<0.05).After the treatment,TNF-α,IL-1 levels,joint pain,joint swelling and morning stiffness time scores were all reduced,and PGE2 levels were all increased(P<0.05); after the treatment,TNF-α,IL-1 levels,joint pain,joint swelling and morning stiffness time scores in the observation group were all decreased(P<0.05).The level of PGE2 was higher than that of the control group(P<0.05).The quality of life in the observation group was significantly better than that in the control group(P<0.05).Conclusion:Yangyin Huoxue Tongluo decoction can significantly alleviate the symptoms of rheumatoid arthritis,improve the level of inflammation and immunity,the clinical effect is satisfactory.

参考文献/References:

[1] 宋 佳,孙 磊,刘 焕,等.早期和非早期类风湿关节炎患者膝关节高频超声表现与多项血清学指标相关性研究[J].陕西医学杂志,2019,48(8):1006-1009.
[2] 王晓芬,龚文英.风湿性疾病慢病管理模式在类风湿关节炎患者中的应用[J].中西医结合护理,2018,4(6):18-21.
[3] 王 燕,陈思思,李泽光.浅谈针药结合治疗类风湿性关节炎的临床应用及作用机制[J].针灸临床杂志,2019,35(6):92-95.
[4] 陈光耀,胡 琪,徐 愿,等.不同中医证候类风湿关节炎患者28关节肌肉骨骼超声表现差异分析[J].中国全科医学,2019,22(21):2616-2620.
[5] 顾玉彪,郑 林,肖涟波,等.中医药预防类风湿关节炎膝关节置换术后深静脉血栓的临床疗效观察[J].中国中西医结合杂志,2019,39(9):1050-1055.
[6] 蔡友治,严世贵.类风湿关节炎的诊断与治疗骨科专家共识[J].中国医学前沿杂志:电子版,2013,5(3):49-52.
[7] 国家食品药品监督管理总局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:115-118.
[8] 中华医学会风湿病学分会.类风湿关节炎诊断及治疗指南[J].中华风湿病学杂志,2010,7(4):265-270.
[9] 韩 曼,巩 勋,唐晓颇,等.中国类风湿关节炎患者报告的临床结局量表优化研究[J].中华中医药学刊,2018,36(9):2116-2120.
[10] 田 园,胡建东.程序性细胞死亡分子-1在类风湿关节炎发病机制中的作用研究进展[J].中华风湿病学杂志,2018,22(4):280-283.
[11] 焦 爽,张春芳,杜晓伟,等.三痹汤加减联合来氟米特片治疗寒湿痹阻型类风湿关节炎的疗效观察[J].河北中医,2018,40(7):991-995.
[12] 戴凤翔,邱联群.当归四逆汤联合灸法治疗类风湿性关节炎临床研究[J].陕西中医,2019,40(9):1235-1237.
[13] 金俊健.养阴活血通络汤治疗类风湿性关节炎的临床疗效观察[J].中国中医药科技,2019,26(4):612-613.
[14] 范晓蕾,刘中华,岳 涛,等.血清TNF-α、IL-1β、IL-6和IL-17表达水平在阿达木单抗治疗活动性类风湿关节炎中的疗效预测作用[J].中国医科大学学报,2018,47(6):556-561.
[15] 曾 肆,谭 谦,童 妍.汝无糯鸡抗类风湿性关节炎的机制[J].中国实验方剂学杂志,2018,8(2):146-151.

相似文献/References:

[1]鲁善为,李松伟.虫类药治疗类风湿关节炎作用机制研究进展[J].陕西中医,2024,(3):427.[doi:DOI:10.3969/j.issn.1000-7369.2024.03.033]

备注/Memo

备注/Memo:
*国家自然科学基金青年科学基金资助项目(81603388)；安徽省卫生和计划生育委员会中医药科研项目(2016ZY37)
更新日期/Last Update: 2020-08-10