[1]郭 琳,王雅婷,考延磊,等.闫雪洁运用寒热并用法治疗溃疡性结肠炎经验*[J].陕西中医,2020,(8):1148.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.036]
　GUO Lin,WANG Yating,KAO Yanlei,et al.Clinical experience of YAN Xuejie in treating ulcerative colitis with the theory of combination of cold and heat[J].,2020,(8):1148.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.036]
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闫雪洁运用寒热并用法治疗溃疡性结肠炎经验*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年8期
页码:
1148
栏目:
名老中医经验
出版日期:
2020-08-05

文章信息/Info

Title:
Clinical experience of YAN Xuejie in treating ulcerative colitis with the theory of combination of cold and heat
作者:
郭 琳1; 王雅婷1; 考延磊2; 闫雪洁2△
1.山东中医药大学(济南250355); 2.山东省烟台市中医医院(烟台 264001)
Author(s):
GUO Lin; WANG Yating; KAO Yanlei; et al.
Shandong University of Traditional Chinese Medicine(Jinan 250355)
关键词:
溃疡性结肠炎;  闫雪洁;  病因病机;  湿热;  寒热并用;  虚实兼顾
Keywords:
Ulcerative colitis;  Yan Xuejie;  Etiology and pathogenesis;  Dampness-heat;  Combination of cold and heat;  Combination of deficiency and reality
分类号:
R516.1
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.036
文献标志码:
A
摘要:
溃疡性结肠炎属临床多发且难治疾病之一,病情反复难愈,严重影响患者生活质量,甚至增加癌变风险。本文旨在探析闫雪洁教授基于“寒热并用”理论治疗溃疡性结肠炎辨治思路及用药特色。闫雪洁教授认为寒热错杂、虚实夹杂为溃疡性结肠炎重要病机,临证常见湿热、热毒、瘀血等多种因素共同作用,损伤肠络而成。病久伤及脾肾,正虚邪恋致病情迁延难愈。临床多表现为寒热、虚实错杂之征象,强调活动期以邪实为主,缓解期以正虚为主。治以寒热并用、虚实兼顾为基本准则,临证讲求分期论治、辨察体质、调气和血、调和阴阳。突出统顾寒热虚实,兼顾气血、体质,结合西医诊治优势,以求标本兼治,减少病情反复,达到最佳治疗效果。用方精当,化裁灵巧,效如桴鼓,为今后临床辨证治疗本病提供经验总结与理论参考。
Abstract:
Ulcerative colitis(UC)is one of the most common and refractory diseases in clinic.Patient's condition is recurrent and hard to recover,which seriously affects the quality of life of patients and even increases the risk of canceration.The purpose of this paper is to analyze Professor Yan Xuejie's treatment of ulcerative colitis based on the theory of “combination of cold and heat” and the characteristics of the medication.Professor Yan Xuejie thinks that the cold-heat complex,and intermingled deficiency and excess are the important pathogenesis of UC.The clinical symptoms are caused by the common dampness-heat,pyrotoxin,blood stasis and other factors,which lead to the damage of intestinal collaterals.Chronic illness will hurt the spleen and kidney,and the disease can delay to recover due to the asthenic healthy qi with pathogen lingering.The clinical manifestations are mostly mixed with cold and heat,deficiency and excess.She emphasizes that the active period is dominated by exuberant pathogen and the remission period was dominated by asthenic healthy qi.The treatment is mainly based on the combination of cold and heat and the combination of deficiency and reality.Clinical practice stresses treating by stages,distinguishing physique,mediating qi and blood,and reconciling Yin and Yang.In order to reduce the recurrence of the disease and treat both the symptoms and the root to achieve the best therapeutic effect,we should pay attention to the combination of cold and heat,give consideration to both qi and blood,physique and the advantages of combining with the Western medicine diagnosis and treatment.It's precise in use,flexible in adding and cutting,and effective is special,which can provide experience summary and theoretical reference for clinical syndrome differentiation in the future.

参考文献/References:

[1] 金晨星,李 芳.UC相关免疫分子及其临床应用的研究进展[J].中国免疫学杂志,2019,35(4):505-508,514.
[2] 周 凤,吴 静.溃疡性结肠炎内科治疗的进展[J].世界华人消化杂志,2016,24(20):3149-3158.
[3] 李竹林,赵 瑛.高强度间歇性运动联合药物治疗溃疡性结肠炎疗效及对患者细胞因子水平影响研究[J].陕西医学杂志,2019,48(7):909-912.
[4] 麦尔哈巴?米吉提,王佳佳,迟 莉,等.中医药治疗溃疡性结肠炎研究进展[J].时珍国医国药,2019,30(3):669-671.
[5] 赵克学,徐 辰,戴高中,等.愈疡膏外敷联合西药治疗复发型活动期溃疡性结肠炎临床研究[J].陕西中医,2020,41(5):600-604.
[6] 陶思玉,金 婧.心理行为干预对溃疡性结肠炎焦虑抑郁患者的影响分析[J].重庆医学,2016,45(32):4596-4599.
[7] 谢晶日,孙 涛,张 冰.溃疡性结肠炎的中医药治疗进展及相关优势探讨[J].辽宁中医杂志,2016,43(2):425-427.
[8] 冯兆张.冯氏锦囊秘录[M].北京: 人民卫生出版社,1998:380.
[9] 巢元方.诸病源候论校释[M].北京:人民卫生出版社,1980:537.
[10] 李东垣.兰室秘藏[M].北京:中国医药科技出版社,2011:75.
[11] 黄元御.长沙药解[M].北京:学苑出版社,2011:13.
[12] 李东阳,李盼盼.参苓白术散治疗溃疡性结肠炎作用机制研究进展[J].现代中医药,2019,39(3):114-119.
[13] 张志聪.本草崇原[M].北京:中国中医药出版社,1992:2.
[14] 罗 美.古今名医方论[M].北京:中国医药科技出版社, 2012:113.
[15] 李乃谦.探讨白芍的药理作用及现代研究进展[J].中医临床研究,2017,9(20):137-138.
[16] 胡妍妍,沈永华,于成功,等.凝血功能检测对评估溃疡性结肠炎患者血液高凝状态的价值[J].江苏医药,2017,43(11):765-769.
[17] 卢晨霞,张 浩,迟宗良,等.赤芍-牡丹皮药对配伍药效物质基础研究[J].中国中医药科技,2018, 25(3):344-345.
[18] 陶弘景.名医别录[M].北京:人民卫生出版社,1986:116.
[19] 吴开春,梁 洁,冉志华,等.炎症性肠病诊断与治疗的共识意见(2018年,北京)[J].中华消化杂志,2018,38(9):796-813.
[20] 刘完素.素问病机气宜保命集[M].北京:中国医药科技出版社,2012:72.
[21] 郭霭春.黄帝内经素问校注[M].北京:人民卫生出版社,1992:52.

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备注/Memo

备注/Memo:
*山东省中医药管理局基金资助项目(2019-0668)
更新日期/Last Update: 2020-08-10