[1]梁春玲,陈晓杰,刘祖发,等.补阳还五汤联合西药治疗急性脑梗死疗效及对患者血管斑块稳定性及血清因子水平的影响*[J].陕西中医,2020,(9):1200-1204.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.006]
　LIANG Chunling,CHEN Xiaojie,LIU Zufa,et al.Effect of Buyang Huanwu decoction combined with western medicine on stability of vascular plaque and serum factor levels in patients with acute cerebral infarction[J].,2020,(9):1200-1204.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.006]
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补阳还五汤联合西药治疗急性脑梗死疗效及对患者血管斑块稳定性及血清因子水平的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年9期
页码:
1200-1204
栏目:
临床研究
出版日期:
2020-09-05

文章信息/Info

Title:
Effect of Buyang Huanwu decoction combined with western medicine on stability of vascular plaque and serum factor levels in patients with acute cerebral infarction
作者:
梁春玲; 陈晓杰; 刘祖发; 刘 杰; 张宗耀; 闫 威△
中国中医科学院望京医院(北京 100102)
Author(s):
LIANG Chunling; CHEN Xiaojie; LIU Zufa; et al.
Wangjing Hospital,Chinese Academy of Traditional Chinese Medicine(Beijing 100102)
关键词:
急性脑梗死;  补阳还五汤;  中医证候积分;  血管斑块稳定性;  脑血流动力学;  血清淀粉样蛋白A;  血清胱抑素C
Keywords:
Acute cerebral infarction;  Buyang Huanwu decoction;  TCM syndrome score;  Vascular plaque stability;  Cerebral hemodynamics;  Serum amyloid A;  Serum cystatin C
分类号:
R743.3
DOI:
DOI:10.3969/j.issn.1000-7369.2020.09.006
文献标志码:
A
摘要:
目的:探讨补阳还五汤联合西药治疗急性脑梗死(ACI)患者的临床效果。方法:选取122例ACI患者,按随机数字表法分两组,各61例。对照组采取常规西药治疗,研究组采取补阳还五汤联合西药治疗,均连续治疗14 d。观察两组中医疗效、不良反应及治疗前后中医证候积分、血管斑块稳定性、脑血流动力学指标[大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)血流速度]、血清胱抑素C(CysC)、淀粉样蛋白A(SAA)水平。结果:研究组总有效率高于对照组(P<0.05),两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,研究组中医证候积分改善幅度大于对照组(P<0.05)。治疗后研究组血管斑块稳定性改善显著,稳定斑块检出率高于对照组(P<0.05)。治疗后两组PCA、ACA、MCA血流速度升高,且研究组高于对照组(P<0.05)。治疗后两组血清SAA、CysC水平降低,且研究组改善幅度大于对照组(P<0.05)。结论:在常规西药基础上联合补阳还五汤治疗ACI,患者中医疗效较好,可有效改善中医症状、体征,稳定斑块,同时能改善缺血区域血流状态,减轻局部炎性反应,治疗安全性较好。
Abstract:
Objective:To explore the clinical effect of Buyang Huanwu decoction combined with western medicineon on patients with acute cerebral infarction(ACI).Methods:122 cases of ACI patients were selected and grouped according to random number table method,61 cases in each.The control group was treated with conventional western medicine,and the study group was treated with Buyang Huanwu decoction based on the control group,all of which were treated continuously for 14 days.Observing the effects of Chinese medicine,adverse reactions,and TCM syndromes score,vascular plaque stability,cerebral hemodynamic indicators [middle cerebral artery(MCA),anterior cerebral artery(ACA),blood flow velocity of posterior cerebral artery(PCA)],serum cystatin C(CysC),amyloid A(SAA)levels before and after treatment in both groups.Results:The total effective rate of the study group was higher than that of the control group(P<0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the improvement of TCM syndrome points in the study group was greater than that in the control group(P<0.05).The stability of vascular plaque in the study group improved significantly after treatment,and the detection rate of stable plaque was higher than that of the control group(P<0.05).After treatment,the blood flow velocity of PCA,ACA and MCA increased in the two groups,and the study group was higher than the control group(P<0.05).After treatment,the serum SAA and CysC levels decreased in the two groups,and the improvement in the study group was greater than that in the control group(P<0.05).Conclusion:On the basis of conventional western medicine,Buyang Huanwu decoction has obvious TCM treatment effect on patients with ACI,which can effectively relieve the symptoms and signs of TCM and stabilize plaque,at the same time,it can improve the blood flow state in the ischemic area,reduce the local inflammatory response,and better safety of treatment.

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备注/Memo

备注/Memo:
*北京市中医药科技发展资金资助项目(JJ2018-93)
更新日期/Last Update: 2020-09-08