[1]施丽娟,刘 娟,张晓冉,等.丹栀逍遥散联合甲巯咪唑治疗甲状腺功能亢进症临床研究*[J].陕西中医,2020,(9):1276-1278,1300.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.028]
　SHI Lijuan,LIU Juan,ZHANG Xiaoran,et al.Clinical study of Danzhi Xiaoyao powder combined with methimazole in treating hyperthyroidism[J].,2020,(9):1276-1278,1300.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.028]
点击复制

丹栀逍遥散联合甲巯咪唑治疗甲状腺功能亢进症临床研究*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年9期
页码:
1276-1278,1300
栏目:
临床研究
出版日期:
2020-09-05

文章信息/Info

Title:
Clinical study of Danzhi Xiaoyao powder combined with methimazole in treating hyperthyroidism
作者:
施丽娟; 刘 娟; 张晓冉; 任晓丽; 赵兰兰; 李 倩
成都中医药大学附属医院内分泌科(成都 610075)
Author(s):
SHI Lijuan; LIU Juan; ZHANG Xiaoran; et al.
Department of Endocrinology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine(Chengdu 610075)
关键词:
甲状腺功能亢进症;  丹栀逍遥散;  甲状腺功能;  骨代谢;  生活质量;  甲巯咪唑;  不良反应
Keywords:
Hyperthyroidism;  Danzhi Xiaoyao powder;  Thyroid function;  Bone metabolism;  Quality of life;  Methimazole;  Adverse reaction
分类号:
R581.1
DOI:
DOI:10.3969/j.issn.1000-7369.2020.09.028
文献标志码:
A
摘要:
目的:探讨丹栀逍遥散联合甲巯咪唑治疗甲状腺功能亢进症疗效及对患者甲状腺功能、生活质量的影响。方法:选取90例甲状腺功能亢进症患者作为研究对象,随机数字表法分为两组,对照组45例用甲巯咪唑,试验组45例在此基础上加用丹栀逍遥散,随症加减用药治疗,比较两组治疗有效率,治疗前后骨代谢和甲状腺功能指标,治疗后生活质量评分以及不良反应情况。结果:治疗结束后,试验组治疗总有效率高于对照组(P<0.05)。治疗后,试验组血清降钙素、骨钙素、总甲状腺素、游离三碘甲腺原氨酸、总三碘甲状腺原氨酸,均低于对照组,甲状旁腺激素、促甲状腺激素均高于对照组(P<0.05)。治疗后两组患者不良反应率比较无统计学意义(P>0.05)。结论:丹栀逍遥散加减联合甲巯咪唑对甲状腺功能亢进症患者有提高疗效、改善骨代谢指标和甲状腺功能指标的作用,可提升患者生活质量。
Abstract:
Objective:To explore the curative effect of Danzhi Xiaoyao powder combined with methimazole on hyperthyroidism and its influences on thyroid function and quality of life.Methods:90 hyperthyroidism patients were enrolled as study objects.They were divided into two groups by random number table method,45 cases in each group.The control group was treated with methimazole,while the experimental group was additionally treated with modified Danzhi Xiaoyao powder,and the medication dose was adjusted based on symptom severity.The response rate of treatment,bone metabolism and thyroid function indexes before and after treatment,quality of life score after treatment and adverse reactions were compared between the two groups.Results:At end of treatment,response rate of treatment in the experimental the group was higher than that in control group(P<0.05).After treatment,serum calcitonin,osteocalcin,free thyroxine,total thyroxine,free triiodothyronine and total triiodothyronine in the experimental group were lower than those in the control the group,while parathyroid hormone and thyroid stimulating hormone were higher than those in the control group(P<0.05).After treatment,there was no significant difference in adverse reactions rate between the two groups(P>0.05).Conclusion:The application of Danzhi Xiaoyao powder combined with methimazole in hyperthyroidism patients is conducive to improving curative effect,bone metabolism and thyroid function indexes,improving their quality of life.

参考文献/References:

[1] 钟小军,汪 洋.自拟健脾解郁方辅助西医对症干预治疗甲亢继发心脏病疗效观察[J].中国中医急症,2019,28(11):2032-2034.
[2] 秦晓新,涂燕红,王 红,等.甲亢危象的血液净化治疗[J].中国急救复苏与灾害医学杂志,2007,2(10):622-623.
[3] Almajdoub M,Lantz M,Peter S.Treatment of swedish patients with graves,hyperthyroidism is associated with changes in acylcarnitine levels[J].Thyroid,2017,27(9):1109-1117.
[4] Hasosah M,Alsaleem K,Qurashi M,et al.Neonatal hyperthyroidism with fulminant liver failure:a case report[J].J Clin Diagn Res,2017,11(4):1-2.
[5] 中华医学会内分泌学分会,《中国甲状腺疾病诊治指南》编写组.中国甲状腺疾病诊治指南-甲状腺功能亢进症[J].中华内科杂志,2007,46(10):876-882.
[6] 国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:385-388.
[7] 刘保一,杨 磊,王本杰,等.激素性股骨头坏死的预防与内科治疗的长期临床随访观察[J].中华医学杂志,2017,97(41):3213-3218.
[8] 陈正萍,易吉秀,凌 冰,等.131I二次治疗Graves甲亢对患者血清相关指标及甲减发生率的影响[J].中国医药导报,2019,16(18):61-64.
[9] 王 玲,剌 梅,宁文君.血清TpoAb、LC3、TgAb、TSH检测在甲状腺疾病早期诊断中的应用价值[J].陕西医学杂志,2018,47(10):1361-1363.
[10] 冯少仁,张 青,黄清梅,等.甲状腺吸碘率对Graves甲亢患者抗甲状腺药物治疗后选择停药时机的价值[J].临床荟萃,2019,34(8):730-733.
[11] 帅优优,张学文.李惠林甲亢养阴方治疗甲状腺功能亢进症经验[J].广州中医药大学学报,2019,36(3):423-427.
[12] 胡礼仪,侯永彬,余莉华,等.白芍总苷对肝癌耐药细胞BEL-7402/ADM耐药性的逆转作用及机制探讨[J].山东医药,2017,57(10):1-4.
[13] 刘志庆,杨莎莎,向 南,等.张勤修运用丹栀逍遥散治疗耳鼻喉科疾病举隅[J].辽宁中医杂志,2018,45(8):1604-1605.
[14] 郭丽萍.柴胡疏肝散治疗慢性胆囊炎及对患者胆囊功能、炎症因子水平的影响[J].陕西中医,2018,39(7):882-884.
[15] 鲁阳侠,孟 帆,周云蕾,等.养阴清热消瘿方联合甲巯咪唑治疗甲亢疗效及对患者甲状腺素水平和骨密度影响的研究[J].陕西中医,2019,40(3):358-360.

相似文献/References:

[1]白书仙,张 波,张 洁,等.痤疮肝郁脾虚证临床研究[J].陕西中医,2021,(3):344.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.019]
[2]黄慧花,税典奎.税典奎辨治食管源性胸痛经验[J].陕西中医,2023,(1):104.[doi:DOI:10.3969/j.issn.1000-7369.2023.01.025]

备注/Memo

备注/Memo:
*重大公共卫生专项科研课题(2100409)
更新日期/Last Update: 2020-09-08