[1]侯志琨,东 淳.丹红注射液对小鼠无氧运动抗疲劳的实验研究*[J].陕西中医,2020,(10):1360-1362,1467.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.004]
　HOU Zhikun,DONG Chun..Experimental study on anti-fatigue effect of Danhong injection on anaerobic exercise in mice[J].,2020,(10):1360-1362,1467.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.004]
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丹红注射液对小鼠无氧运动抗疲劳的实验研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年10期
页码:
1360-1362,1467
栏目:
基础研究
出版日期:
2020-10-05

文章信息/Info

Title:
Experimental study on anti-fatigue effect of Danhong injection on anaerobic exercise in mice
作者:
侯志琨; 东 淳
陕西中医药大学(咸阳 712046)
Author(s):
HOU Zhikun; DONG Chun.
Shaanxi University of Chinese Medicine(Xianyang 712046)
关键词:
丹红注射液;  无氧运动能力;  游泳实验;  抗疲劳;  超氧化物歧化酶;  小鼠
Keywords:
Danhong injection;  Anaerobic exercise capacity;  Swimming experiment;  Anti-fatigue;  Superoxide dismutase;  Mice
分类号:
R827.7
DOI:
DOI:10.3969/j.issn.1000-7369.2020.10.004
文献标志码:
A
摘要:
目的:探讨丹红注射液对小鼠无氧运动抗疲劳能力的影响。方法:取昆明种小鼠75只随机分为五组,空白组、训练组、丹红注射液低剂量组(0.05 ml/kg)、丹红注射液高剂量组(0.1 ml/kg)、红景天胶囊阳性对照组(0.674 g/kg),阳性组灌胃给药,其他组腹腔注射给药30 d后,分别测定小鼠在25 ℃的游泳池游泳及负重游泳后,力竭游泳时间、体质量变化,以及对生化指标肝组织匀浆中超氧化物歧化酶(SOD)、丙二醛(MDA); 血浆中血乳酸(LD)、血红蛋白(Hb); 血清中乳酸脱氢酶(LDH)、血尿素氮(BUN)的影响。结果:丹红注射液与训练组比较小鼠的体重有增加趋势但不明显,高剂量组、低剂量组均可明显延长小鼠的游泳时间(P<0.05),显著增加血浆中Hb的储备量和降低LD含量(P<0.05),提高肝组织匀浆中SOD活性,降低MDA含量(P<0.05),提高小鼠血清LDH活性和降低SUN含量(P<0.05)。结论:丹红注射液可以增加小鼠的运动能力,提高耐缺氧能力,延缓游泳小鼠疲劳的发生。
Abstract:
Objective:To investigate the effect of Danhong injection on anti-fatigue ability of mice in anaerobic exercise.Method:75 Kunming mice were randomly divided into 5 groups,blank group,training group,Danhong injection low dose group(0.05 ml/kg),high dose group(0.1 ml/kg)and Rhodiola capsule positive control group(0.674 g/kg).The rats in positive control group were treated with intragastric injection and other rats intraperitoneal injection.30 days later,after swimming and weight-bearing swimming at 25 ℃,the exhaustive swimming time,body weight change,biochemical indexes of superoxide dismutase(SOD),malonaldehyde(MDA),blood lactate(LD),hemoglobin(Hb),lactate dehydrogenase(LDH)and blood urea nitrogen(BUN)of these mice were measured.Results:Compared with training group,Danhong injection had a tendency to increase the weight of mice but not obvious.The swimming time of mice was significantly prolonged in high dose group and low dose group(P<0.05),the reserve of Hb was significantly increased.The activity of SOD in liver homogenate was increased and the content of MDA was decreased(P<0.01,P<0.05),LD content in serum of mice in high dose group after exercise was lower(P<0.05)and the serum LDH activity was increased(P<0.05).The high dose group,the low dose group and the positive control group had vary degrees of difference.Conclusion:Danhong injection can increase the athletic ability of mice,improve the ability of hypoxia tolerance,and delay the occurrence of fatigue in swimming mice.

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备注/Memo

备注/Memo:
*陕西省自然科学基础研究计划项目(S2018-JC-YB-2097)
更新日期/Last Update: 2020-10-10