[1]毛利云,朱 铮,王屹雯,等.补肾填精行气活血法治疗中重度宫腔粘连疗效研究*[J].陕西中医,2020,(12):1731-1734.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.013]
　MAO Liyun,ZHU Zheng,WANG Yiwen,et al.Study on the therapeutic effect of Bushen Tianjing Xingqi Huoxue on moderate to severe intrauterine adhesion[J].,2020,(12):1731-1734.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.013]
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补肾填精行气活血法治疗中重度宫腔粘连疗效研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年12期
页码:
1731-1734
栏目:
临床研究
出版日期:
2020-12-05

文章信息/Info

Title:
Study on the therapeutic effect of Bushen Tianjing Xingqi Huoxue on moderate to severe intrauterine adhesion
作者:
毛利云; 朱 铮; 王屹雯; 颜望碧△
江苏省无锡市中医医院妇科(无锡 214071)
Author(s):
MAO Liyun; ZHU Zheng; WANG Yiwen; et al.
Department of Gynecology,Wuxi Hospital of Traditional Chinese Medicine in Jiangsu Province(Wuxi 214071)
关键词:
补肾填精行气活血;  宫腔粘连;  子宫内膜;  血管内皮生长因子;  雌激素受体
Keywords:
Bushen Tianjing Xingqi Huoxue;  Intrauterine adhesion;  Endometrium;  Vascular endothelial growth factor;  Estrogen receptor
分类号:
R711
DOI:
DOI:10.3969/j.issn.1000-7369.2020.12.013
文献标志码:
A
摘要:
目的:研究补肾填精行气活血法治疗中重度宫腔粘连临床疗效及可能的作用机制。方法:将66例中重度宫腔粘连术后患者随机分成两组,对照组33例,给予雌孕激素人工周期治疗,治疗组33例,在对照组基础上联合中药治疗,治疗3个月后观察两组在总疗效、子宫内膜厚度、宫腔粘连评分等指标的比较情况。结果:治疗后,对照组患者的治疗总有效率为63.63%,研究组患者的治疗总有效率为84.84%,研究组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组患者子宫内膜厚度、妊娠率均高于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组患者IUA评分、VEGF积分均低于对照组,差异有统计学意义(P<0.05)。结论:雌孕激素人工周期联合补肾填精行气活血法治疗中重度宫腔粘连,能有效预防宫腔再粘连,提高临床疗效。
Abstract:
Objective:To study the clinical efficacy and possible mechanism of Bushen Tianjing Xingqi Huoxue in the treatment of moderate to severe intrauterine adhesion.Methods: 66 patients with moderate to severe intrauterine adhesion were randomly divided into two groups after operation.33 cases in the control group were treated with estrogen and progesterone,and 33 cases in the treatment group combined treatment with traditional Chinese medicine.After 3 months of treatment,the total efficacy,endometrial thickness,intrauterine adhesion score and other indicators were observed.Results: The total effective rate of the control group was 63.63%,and the total effective rate of the study group was 84.84%,which was higher than that of the control group,differences statistically significant(P<0.05).After treatment,the endometrial thickness and pregnancy rate of the treatment group were higher than those of the control group(P<0.05).After treatment,IUA scores and VEGF scores in the treatment group were lower than those in the control group,differences statistically significant(P<0.05).Conclusion:Artificial cycle of estrogen and progesterone combined therapy of Bushen Tianjing Xingqi Huoxue in the treatment of moderate to severe intrauterine adhesion can effectively prevent intrauterine adhesions,improve clinical efficacy.

参考文献/References:

[1] 王 彦,姜学强.妇科微创手术操作与技巧[M].北京:人民卫生出版社,2011:208-209.
[2] 陈玉清,常亚杰,杨 欢.重度宫腔粘连子宫内膜修复中微血管密度及VEGF的表达及其临床意义[J].新医学,2016,47(10):671-675.
[3] 欧小凤.宫腔粘连与子宫内膜雌激素受体和孕激素受体的表达特点及意义分析[J].中国实用医药,2014,9(22):91-93.
[4] 赵现立,南 燕,齐 进,等.中重度宫腔粘连宫腔镜电切术后两种方案预防再粘连临床研究[J].陕西医学杂志,2018,47(2):165-167.
[5] 夏恩兰.宫腔镜学及图谱[M].郑州:河南科学技术出版社,2009:148-151.
[6] 巩克亭,张传军,李建鹏.宫腔粘连诊疗研究进展[J].临床合理用药杂志,2019,12(13):186-187.
[7] 张 莉,吴乃文,杨永华.IL-18、TNF-α、VEGF在宮腔粘连患者子宫内膜中的表达及临床意义[J].中国医药科学,2015,5(5):208-210.
[8] 曾薇薇,姚吉龙,李 军.胰岛素样生长因子-1和转化生长因子-β1在宫腔粘连患者子宫内膜表达[J].广西医学,2015,37(4):470-472.
[9] 孙聪聪,王 佳,明 雪,等.宫腔粘连患者子宫内膜组织中uPA、PAI-1、TGF-β1的表达及其相关性研究[J].重庆医科大学学报,2016,41(7):690-693.
[10] 徐 洁,刘 艳,郭遂群.雌激素受体及基质金属蛋白酶-9在宫腔粘连组织中的表达及意义[J].广东医学,2015,36(8):1222-1225.
[11] 孙 雷.中药植物雌激素补肾活血化瘀[J].中国老年学杂志,2019,39(19):4875-4880.
[12] 牛红萍,詹兴秀,周晓娜,等.加味桃红四物汤联合芬吗通在宫腔粘连中的应用研究[J].陕西中医,2018,39(2): 205-207.
[13] 刘 亚,张晓明.血府逐瘀胶嚢用于宫腔粘连术后治疗临床观察[J].陕西中医,2017,38(11):1550-1551.
[14] 周琴琴,金群俏,胡小军.COOK球囊联合医用几丁糖预防重度宫腔粘连术后再次宫腔粘连的临床分析[J].实用妇产科杂志,2017,33(9):716-718.
[15] 王雪峰,陈燕英,刘海叶,等.大剂量戊酸雌二醇预防重度宫腔粘连分离术后复发的疗效[J].实用医学杂志,2013,29(16):2716-2718.
[16] 郭小艳,于桂萍.抗幽门螺杆菌疗法联合新辅助化疗对胃癌术后疗效及患者血清VEGF、bFGF的影响[J].陕西医学杂志,2019,48(8):1010-1012,1031.
[17] 陈艳明,李勇坚,刘金娟, 等.VEGF、PEDF在寻常型银屑病组织中的表达及与微血管密度的关系[J].皮肤病与性病,2019,41(3):318-320.

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备注/Memo

备注/Memo:
*江苏省中医药科技项目(LZ09100)
更新日期/Last Update: 2020-12-11