[1]李 纯,刘 洋,王春柳,等.纳米载体经皮给药治疗银屑病研究进展[J].陕西中医,2021,(1):134-136.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.037]
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纳米载体经皮给药治疗银屑病研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年1期
页码:
134-136
栏目:
综述
出版日期:
2021-01-05

文章信息/Info

作者:
李 纯1刘 洋2王春柳2刘琪琪1张 红2李 晔2
(1.陕西中医药大学药学院,陕西 咸阳 712046; 2.陕西省中医药研究院,陕西 西安 710003)
关键词:
银屑病 发病机制 治疗方式 新剂型 经皮给药
分类号:
R 758.63
DOI:
DOI:10.3969/j.issn.1000-7369.2020.01.037
文献标志码:
A
摘要:
银屑病是一种自身性免疫性皮肤疾病,发病机制复杂,目前尚不清楚。临床表现为:角质层增厚、红斑、鳞屑。目前,治疗银屑病的方式有全身、局部以及日光浴治疗。由于局部治疗可以直接接触患者皮肤、避免过代谢以达到治疗目的,故为主要治疗方式。传统局部经皮给药系统无法克服银屑病角质层增厚屏障,药物无法通过角质层,没有达到理想治疗效果。纳米载体剂型透皮给药有助于克服无法通过角质层的缺陷,从而提高药物的生物利用度和渗透量,近年来广泛应用于银屑病治疗。本文结合国内外有关银屑病发病机制、治疗方式以及纳米载体经皮治疗银屑病方面文献进行汇总,以期为纳米载体经皮给药治疗银屑病研究提供参考依据。

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备注/Memo

备注/Memo:
基金项目:陕西省科技计划项目(2017SF-309); 西安市科技计划项目[(2017122SF/YX016(13)]
更新日期/Last Update: 2021-01-11