[1]陈 星,马梦良,倪莹莹.补肾填精法治疗多系统萎缩致体位性低血压疗效及对患者自主神经功能的影响[J].陕西中医,2021,(2):177-179.[doi:DOI:10.3969/j.issn.1000-7369.2020.02.010]
　CHEN Xing,MA Mengliang,NI Yingying.Effect of Bushen Tianjing therapy on postural hypotension caused by multiple system atrophy and its influence on autonomic nerve function[J].,2021,(2):177-179.[doi:DOI:10.3969/j.issn.1000-7369.2020.02.010]
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补肾填精法治疗多系统萎缩致体位性低血压疗效及对患者自主神经功能的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年2期
页码:
177-179
栏目:
临床研究
出版日期:
2021-02-05

文章信息/Info

Title:
Effect of Bushen Tianjing therapy on postural hypotension caused by multiple system atrophy and its influence on autonomic nerve function
作者:
陈 星; 马梦良; 倪莹莹
(广东三九脑科医院, 广东 广州 510510)
Author(s):
CHEN Xing; MA Mengliang; NI Yingying
(Guangdong Sanjiu Brain Hospital,Guangzhou 510510,China)
关键词:
多系统萎缩;  体位性低血压;  补肾填精法;  自主神经功能;  肛门括约肌肌电图
Keywords:
Multiple system atrophy;  Postural hypotension;  Autonomic nerve function;  Bushen Tianjing method;  Anal sphincter electromyography
分类号:
R 742
DOI:
DOI:10.3969/j.issn.1000-7369.2020.02.010
文献标志码:
A
摘要:
目的:探讨补肾填精法治疗多系统萎缩(MSA)致体位性低血压(OH)的疗效及对患者自主神经功能的影响。方法: 选取MSA患者80例,随机分为观察组和对照组各40例。对照组给予单纯西药对症治疗,观察组在对照组用药基础上给予补肾填精法治疗。比较两组治疗前后卧立位收缩压差、卧立位舒张压差、肛门括约肌肌电图(EAS-EMG)情况、交感皮肤反应(SSR)情况及临床疗效。结果:治疗后,两组卧立位收缩压差、卧立位舒张压差值均明显减少,观察组更明显(均P<0.05)。治疗后,两组自发电位出现率、募集电位单纯相出现率及MUP平均时限均明显降低,且观察组更明显(均P<0.05)。观察组治疗总有效率高于对照组(P<0.05)。治疗后,两组SSR潜伏期缩短,波幅增高,且观察组更明显(均P<0.05)。结论:补肾填精法可改善多系统萎缩致体位性低血压患者的直立性低血压症状,促进患者自主神经功能康复,改善临床症状,临床疗效较为满意,且安全性高。
Abstract:
Objective:To investigate the therapeutic effect of Bushen Tianjing method on postural hypotension(OH)in patients with multiple system atrophy(MSA)and its influence on autonomic nerve function.Methods:80 patients with MSA were randomly divided into observation group(40 cases)and control group(40 cases).The control group was given western medicine symptomatic treatment,and the observation group was given Bushen Tianjing therapy on the basis of the control group.Results:After treatment,the difference of systolic pressure and diastolic blood pressure in supine and upright position of the two groups decreased significantly,especially in the observation group(all P<0.05).After treatment,the rate of spontaneous potential,the rate of single phase of recruitment potential and the average time limit of MUP in the two groups were significantly reduced,and the observation group was more obvious(all P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the latency of SSR in the two groups was shortened and the amplitude was increased,and the observation group was more obvious(P<0.05).Conclusion:The method of Bushen Tianjing can improve the symptoms of orthostatic hypotension in OH patients,promote the recovery of autonomic nerve function and improve the clinical symptoms.The clinical efficacy is satisfactory and the safety is high,which is worthy of further application and promotion.

参考文献/References:

[1] 孟庆云,程 娟,王 凯,等.多系统萎缩患者自主神经功能障碍的临床研究[J].中国临床保健杂志,2019,22(1):90-93.
[2] 王万宏,李琳琳,毕鸿雁,等.多系统萎缩中医康复治疗的研究进展[J].医学综述,2018,24(11):162-166.
[3] 张靖寒,杨 铭.针灸治疗多系统萎缩的临床研究进展[J].中华针灸电子杂志,2018,7(4):163-165.
[4] 黄世杰.骨髓过氧化物酶抑制剂BHV-3241治疗多系统萎缩症的Ⅲ期临床试验可继续进行[J].国际药学研究杂志,2019,46(1):77.
[5] 唐北沙,陈生弟,中华医学会神经病学分会帕金森病及运动障碍学组,等.多系统萎缩诊断标准中国专家共识[J].中华老年医学杂志,2017,36(10):1055-1060.
[6] 国家食品药品监督管理总局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:115-118.
[7] 曹振汤,吴瑀峰,刘亘梁,等.唾液细胞外囊泡中α-突触核蛋白寡聚体诊断多系统萎缩-帕金森型的价值[J].中国神经免疫学和神经病学杂志,2019,26(1):25-29.
[8] 张美美,冯 涛.α-突触核蛋白致病机制研究进展[J].中华神经科杂志,2020,53(3):227-231.
[9] 杨 旭.中医治疗多系统萎缩体位性低血压研究进展[J].中华中医药杂志,2019,34(6):2624-2626.
[10] 范华娟.多系统萎缩的临床症状及早期诊断的价值体会[J].世界复合医学,2019,5(4):26-28.
[11] 陆佳宁,张丽萍,冯秀珍,等.基于肾脑相济理论探析裘昌林教授辨治多系统萎缩的临证经验[J].浙江中医药大学学报,2019,43(1):18-22.
[12] 邹建鹏,毕鸿雁,彭 伟,等.基于脑肾轴理论多系统萎缩中医康复模式的建立[J].山东中医杂志,2019,38(1):14-17.
[13] 赵 欢,杨东东,郭 强,等.基于“精-血-髓一体论”观察当归补血汤治疗血管性痴呆临床研究[J].陕西中医,2016,37(10):1314-1315.
[14] 许浩游,李 霞,方素鹏.刘茂才辨证论治多系统萎缩经验介绍[J].新中医,2019,51(1):268-270.
[15] 李 哲,刘树佳,翁玉玲,等.熟地黄多糖联合同步放疗对鼻咽癌增殖转移的影响研究[J].陕西医学杂志,2018,47(8):1003-1006.

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备注/Memo

备注/Memo:
基金项目:广东省医学科学技术研究基金资助项目(B2018088)
更新日期/Last Update: 2021-01-28