[1]李承秋,吕文艺,金 凡,等.活血消异汤联合米非司酮对子宫内膜异位症患者血清MMP-3、CA125、EMAb水平的影响[J].陕西中医,2021,(3):297-300.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.006]
　LI Chengqiu,LV Wenyi,JIN Fan,et al.Effect of Huoxue Xiaoyi decoction combined with mifepristone on the serum levels of MMP-3,CA125 and EMAb in patients with endometriosis[J].,2021,(3):297-300.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.006]
点击复制

活血消异汤联合米非司酮对子宫内膜异位症患者血清MMP-3、CA125、EMAb水平的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年3期
页码:
297-300
栏目:
临床研究
出版日期:
2021-03-09

文章信息/Info

Title:
Effect of Huoxue Xiaoyi decoction combined with mifepristone on the serum levels of MMP-3,CA125 and EMAb in patients with endometriosis
作者:
李承秋1; 吕文艺1; 金 凡1; 陈建新2
(1.武汉大学人民医院妇科,湖北 武汉 430060; 2.武汉大学中南医院妇科,湖北 武汉 430060)
Author(s):
LI Chengqiu; LV Wenyi; JIN Fan; CHEN Jianxin
(Department of Gynecology People's Hospital of Wuhan University,Wuhan 430060,China)
关键词:
子宫内膜异位症;  活血消异汤;  基质金属蛋白酶-3;  糖类抗原125;  抗子宫内膜抗体;  米非司酮
Keywords:
Endometriosis;  Huoxue Xiaoyi decoction;  Matrix metalloproteinase-3;  Carbohydrate antigen 125;  Anti-endometrial antibody;  Mifepristone
分类号:
R 711.11
DOI:
DOI:10.3969/j.issn.1000-7369.2020.03.006
文献标志码:
A
摘要:
目的:研究米非司酮联合活血消异汤治疗子宫内膜异位症疗效,以及对基质金属蛋白酶 3(MMP-3)、糖类抗原125(CA125)、抗子宫内膜抗体(EMAb)水平的影响。方法:选取260例子宫内膜异位症患者随机分为对照组和观察组,两组各130例。观察组采用活血消异汤联合米非司酮治疗,对照组采用米非司酮治疗。比较两组临床疗效、中医症候评分、复发、妊娠及流产情况、血清学指标及不良反应。结果:治疗后观察组临床疗效及各项中医症候评分优于对照组,组间差异有统计学意义(均P<0.05)。观察组MMP-3、CA125、EMAb水平指标低于对照组,观察组复发率低于对照组,组间差异有统计学意义(均P<0.05)。观察组妊娠率高于对照组,组间差异有统计学意义(P<0.05)。两组患者药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:活血消异汤联合米非司酮治疗比单用米非司酮更具优势,可增强其临床疗效,改善中医证候,降低MMP-3、CA125、EMAb水平和疾病复发率,有助于提高女性妊娠。
Abstract:
Objective:To study the effect of mifepristone combined with Huoxue Xiaoyi decoction on matrix metallo proteinase-3(MMP-3),carbohydrate antigen 125(CA125)and anti-endometrial antibody(EMAb)in patients with endometriosis.Methods:260 patients with endometriosis were randomly divided into control group(n=130)and observation group(n=130).The observation group was treated with Huoxue Xiaoyi decoction combined with mifepristone,and the control group was treated with mifepristone alone.The clinical efficacy,serological indicators and adverse reactions were compared between the two groups.Results:After treatment,the clinical efficacy and TCM symptom scores of the observation group were significantly better than those of the control group(all P<0.05).The levels of MMP-3,CA125 and EMAb,recurrence rate of observation group were significantly lower than those in the control group(all P<0.05).The pregnancy rate was significantly higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:Huoxue Xiaoyi decoction combined with mifepristone has more advantages than mifepristone alone,which can enhance clinical efficacy,improve TCM syndromes,reduce the levels of MMP-3,CA125,EMAb and disease recurrence rate,thus improving pregnancy outcome.

参考文献/References:

[1] 陈 曦,徐丛剑.子宫内膜异位症恶变研究进展[J].中国实用妇科与产科杂志,2017,33(12):1300-1303.
[2] 郭耀省,孙 青.子宫内膜异位症的发病机制研究进展[J].新乡医学院学报,2018,35(5):439-443.
[3] 曹现岭.子宫内膜异位症的遗传学发病机制研究进展[J].国际生殖健康计划生育杂志,2019,38(1):67-70,82.
[4] 武 力,郑海燕.子宫内膜异位症分子生物学研究进展[J].医学综述,2015,21(5):845-846.
[5] 赵玲娟,孔方方,邵艳社.子宫内膜异位症中西医治疗进展[J].解放军医药杂志,2015,27(6):114-115.
[6] 武 梅,刘德慧,俞超芹.子宫内膜异位症中医证候初探[J].辽宁中医杂志,2020,47(5):38-44.
[7] 沈 铿,马 丁.妇产科学[M].北京:人民卫生出版社,2015:747-762.
[8] 张惜明.实用妇产科学[M].北京:人民卫生出版社,2011:2031-2044.
[9] 国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药出版社,2002:73-75.
[10] 徐迪华,徐剑秋.中医量化诊断[M].南京:江苏科学技术出版社,1997:21-28.
[11] 林 静,王志美,徐 洋,等.活血化瘀汤联合孕三烯酮治疗子宫内膜异位症的疗效观察[J].陕西中医,2017,38(11):1546-1547.
[12] 任国平,王保莲,王艳红.补肾活血化瘀法对子宫内膜异位症患者血流变学及TNF-α水平的影响[J].陕西中医,2017,38(9):1208-1209.
[13] 王娜娜,赵瑞华,夏文艳.活血消异方抑制盆腔子宫内膜异位症保守术后复发的病例研究[J].中华中医药杂志,2017,32(8):543-546.
[14] 杨 扬,龚护民,袁少洋.小金丸联合戈舍瑞林治疗子宫内膜异位症的临床研究[J].现代药物与临床,2018,33(9):2326-2330.
[15] 古力巴哈提?夏米尔,热米拉?托乎提,吾力也提,等.大黄虫丸联合醋酸亮丙瑞林治疗子宫内膜异位症的临床研究[J].现代医学,2018,46(8):901-906.
[16] 张海燕,赵得雄.曼月乐保守治疗子宫内膜异位症的疗效及对子宫动脉血流动力学、血清EMAb及激素水平的影响[J].贵州医药,2019,43(1):34-37.
[17] 王彩霞,苏元花,万 丹.血府逐瘀汤联合痛愈舒颗粒治疗子宫内膜异位症临床疗效及对血清EMAb、VEGF水平的影响[J].湖北中医药大学学报,2020,22(1):31-34.
[18] 赵金娟,陶存武.卵巢子宫内膜异位囊肿患者血清CA125及EMAb检测的临床意义[J].陕西医学杂志,2012,41(6):682-684.
[19] Liu HZ,Han XX,Liu J,et al.Effect of Taoren Quyu decoction on human endometrial cells and its anti-endometriosis activity in rats[J].Asian Pac J Trop Med,2017,10(7):696-700.
[20] 罗亚辉.地屈孕酮对子宫内膜异位症患者血清CA125的影响[J].陕西医学杂志,2017,46(3):402-404.
[21] 韦 唯,向 浩,李 晨.活血健脾方合薏苡仁油对大肠癌术后患者生活质量、免疫功能及炎性因子水平的影响[J].现代中西医结合杂志,2020,29(18):1987-1989,1994.
[22] 马振中,李晓琦,黄萌萌, 等.不同产地薏苡仁药材中甘油三酯和脂肪酸含量测定及其质量评价[J].中草药,2020,51(1):210-215.
[23] 吕 鹏,赵 欢,李蕊白, 等.薏苡仁油注射液用于32例老年急性髓系白血病围诱导化疗期患者疗效观察[J].北京中医药,2019,38(6):541-545.
[24] 王 会,金 平,梁新合,等.鸡内金化学成分和药理作用研究[J].吉林中医药,2018,38(9):85-87.
[25] 袁 媛,吴 芹,石京山,等.丹参及其主要成分保肝作用的研究进展[J].中国中药杂志,2015,40(4):588-589.
[26] 赵志梅,张立杰,夏 天,等.莪术主要单体成分抗炎,抗肿瘤作用研究进展[J].药物评价研究,2017,40(1):119-124.
[27] 王新苗,邸 莎,王 青,等.赤芍的临床应用及其用量探究[J].吉林中医药,2019,39(8):1017-1020.

相似文献/References:

[1]胡贞君,刘笑梅△,曹保利.复方莪术散治疗子宫内膜异位症疗效及其分子学研究进展*[J].陕西中医,2019,(9):1315.
[2]张 莉,金 晶,季 菲△.丹莪妇康煎膏联合孕三烯酮治疗子宫内膜异位症疗效及对患者CA125、TNF-α和IL-6水平的影响*[J].陕西中医,2020,(10):1370.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.007]
[3]陈亚杰,闻 姬.子宫内膜异位症中西医认识及治疗研究进展[J].陕西中医,2021,(10):1486.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.043]
[4]余 震,柳 洲.消瘤方对子宫内膜异位症大鼠盆腔粘连的影响[J].陕西中医,2022,(1):13.[doi:DOI:10.3969/j.issn.1000-7369.2022.01.003]
　YU Zhen,LIU Zhou.Effect and the mechanism of Xiaoliu decoction on pelvic adhesion in rats with endometriosis[J].,2022,(3):13.[doi:DOI:10.3969/j.issn.1000-7369.2022.01.003]
[5]董秀娟,曹若愚,于洪基,等.大蒜素对子宫内膜异位症大鼠异位病灶及缺氧诱导因子-1α表达的影响[J].陕西中医,2022,(4):432.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.005]
　DONG Xiujuan,CAO Ruoyu,YU Hongji,et al.Effects of Allicin on the ectopic lesions and the expression of HIF-1α in rats with endometriosis[J].,2022,(3):432.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.005]
[6]赵 娜,周灵雪,杨向荣.桂枝茯苓胶囊联合戈舍瑞林对子宫内膜异位症患者子宫动脉血流动力学及Th1/Th2细胞因子的影响[J].陕西中医,2022,(4):446.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.008]
　ZHAO Na,ZHOU Lingxue,YANG Xiangrong.Effects of Guizhi Fuling capsule combined with goserelin on uterine artery hemodynamics and Th1/Th2 cytokines in endometriosis patients[J].,2022,(3):446.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.008]
[7]刘 叶,赵亚芹.活血通络解毒汤治疗子宫内膜异位症疗效及对患者卵巢功能的影响[J].陕西中医,2022,(4):450.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.009]
　LIU Ye,ZHAO Yaqin.Therapeutic effect of Huoxue Tongluo Jiedu decoction on endometriosis and its influence on ovarian function of patients[J].,2022,(3):450.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.009]
[8]宋梦杨,连 方.连方教授治疗子宫内膜异位症经验[J].陕西中医,2022,(4):511.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.026]
　SONG Mengyang,LIAN Fang.LIAN Fang's experience in treating endometriosis with Quyu Jiedu decoction[J].,2022,(3):511.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.026]
[9]杨润雨,陈 瑶,冯晓玲.中医药治疗子宫内膜异位症致不孕研究进展[J].陕西中医,2023,(5):670.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.032]
　YANG Runyu,CHEN Yao,FENG Xiaoling.Research progress of traditional Chinese medicine in the treatment of infertility caused by endometriosis[J].,2023,(3):670.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.032]
[10]赵佳琪,刘凯莉,李昱帅,等.子宫内膜异位症相关通路及中医药干预研究进展[J].陕西中医,2023,(9):1316.[doi:DOI:10.3969/j.issn.1000-7369.2023.09.038]
　ZHAO Jiaqi,LIU Kaili,LI Yushuai,et al.Research progress on the related pathways of endometriosis and the intervention of traditional Chinese medicine[J].,2023,(3):1316.[doi:DOI:10.3969/j.issn.1000-7369.2023.09.038]

备注/Memo

备注/Memo:
基金项目:湖北省自然科学基金资助项目(2018KJU805343)
更新日期/Last Update: 2021-03-08