[1]崔 志,蔡 华,马淑红,等.芪明颗粒联合西药治疗糖尿病周围神经病变临床研究[J].陕西中医,2021,(3):312-314.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.010]
　CUI Zhi,CAI Hua,MA Shuhong,et al.Clinical study of Qiming granule combined with western medicine on diabetic peripheral neuropathy[J].,2021,(3):312-314.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.010]
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芪明颗粒联合西药治疗糖尿病周围神经病变临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年3期
页码:
312-314
栏目:
临床研究
出版日期:
2021-03-09

文章信息/Info

Title:
Clinical study of Qiming granule combined with western medicine on diabetic peripheral neuropathy
作者:
崔 志; 蔡 华; 马淑红; 蒋一凡; 王 刚; 陈 佳
(盘锦辽油宝石花医院,辽宁 盘锦 124000)
Author(s):
CUI Zhi; CAI Hua; MA Shuhong; JIANG Yifan; WANG Gang; CHEN Jia
(Panjin Liaoyou Gem Flower Hospital,Panjin 124000,China)
关键词:
糖尿病周围神经病变;  核因子κB;  尼莫地平;  芪明颗粒;  同型半胱氨酸;  神经功能
Keywords:
Diabetic peripheral neuropathy;  Nuclear factor-κB;  Nimodipine;  Qiming granule;  Homocysteine;  Nerve function
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7369.2020.03.010
文献标志码:
A
摘要:
目的:探讨芪明颗粒联合西药治疗糖尿病周围神经病变患者临床疗效。方法:将80例2型糖尿病周围神经病变患者随机分为对照组(n=40)与观察组(n=40)。对照组予尼莫地平治疗,观察组在对照组基础上予芪明颗粒治疗,对比两组患者的前腓总神经与正中神经的感觉神经传导速度(SNCV)、运动神经传导速度(MNCV)、血清中血清同型半胱氨酸(Hcy)、核因子κB(NF-κB)、不良反应发生率及疗效。结果:两组患者治疗前腓总神经与正中神经的SNCV、MNCV、Hcy、NF-κB、不良反应发生率比较,差异无统计学意义(均P>0.05)。观察组治疗后腓总神经与正中神经的SNCV、MNCV均比对照组更高,而治疗后Hcy、NF-κB比对照组更低,差异有统计学意义(均P<0.05)。观察组治疗总有效率比对照组高,差异有统计学意义(P<0.05)。结论:芪明颗粒联合西药治疗糖尿病周围神经病变效果较好,能够有效改善患者的神经功能,促进康复。
Abstract:
Objective:To investigate the clinical effect of Qiming granule combined with western medicine on diabetic peripheral neuropathy.Methods:80 patients with type 2 diabetic peripheral neuropathy were randomly divided into control group(n=40)and observation group(n=40).The control group was treated with nimodipine,and the observation group was treated with Qiming granule on the basis of control group.The sensory nerve conduction velocity(SNCV)and motor nerve conduction velocity(MNCV)of common,serum homocysteine(Hcy),nuclear factor-κB(NF-κB),adverse reaction rate and curative effect were compared between the two groups.Results:There was no significant difference in SNCV,MNCV,Hcy,NF-κB and adverse reaction rate(all P>0.05).After the treatment,the SNCV、MNCV peroneal nerve and median nerve in the observation group was higher than those in the control group,and after treatment Hcy、NF-κB lower than the control group,difference statistically significant(all P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,difference statistically significant(P<0.05).Conclusion:Qiming granule combined with western medicine has remarkable effect on diabetic peripheral neuropathy,which can effectively improve the neurological function of patients and promote the rapid recovery of the body.

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更新日期/Last Update: 2021-03-08