[1]董 一,王静云,马 君,等.保元汤合血府逐瘀汤治疗气虚血瘀型急性脑梗死临床研究[J].陕西中医,2021,(5):590-593.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.011]
　DONG Yi,WANG Jingyun,MA Jun,et al.Baoyuan decoction and Xiefu Zhuyu decoction in treating acute cerebral infarction of Qi deficiency and blood stasis type[J].,2021,(5):590-593.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.011]
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保元汤合血府逐瘀汤治疗气虚血瘀型急性脑梗死临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年5期
页码:
590-593
栏目:
临床研究
出版日期:
2021-05-05

文章信息/Info

Title:
Baoyuan decoction and Xiefu Zhuyu decoction in treating acute cerebral infarction of Qi deficiency and blood stasis type
作者:
董 一1; 王静云1; 马 君1; 胡日光1; 解建业2
(1.青岛市胶州中心医院,山东 青岛266300; 2.青岛大学附属医院,山东 青岛 266003)
Author(s):
DONG Yi; WANG Jingyun; MA Jun; HU Riguang; XIE Jianye
(Qingdao Jiaozhou Central Hospital,Qingdao 266300,China)
关键词:
急性脑梗死;  保元汤;  血府逐瘀汤;  气虚血瘀;  白细胞介素-33;  视锥蛋白样蛋白-1
Keywords:
Acute cerebral infarction;  Baoyuan decoction;  Xiefu Zhuyu decoction;  Qi deficiency and blood stasis;  Interleukin-33;  Trypanin-like protein-1
分类号:
R 743.3
DOI:
DOI:10.3969/j.issn.1000-7369.2020.05.011
文献标志码:
A
摘要:
目的:探究保元汤合血府逐瘀汤治疗气虚血瘀型急性脑梗死效果及对白细胞介素-33(IL-33)及视锥蛋白样蛋白-1(VILIP-1)的影响。方法:选取病例86例,按照随机数字表法分为对照组(采用常规方法进行治疗)和观察组(在对照组的基础上加用保元汤合血府逐瘀汤治疗),每组均为43例,两组均治疗1个月,观察两组治疗前后中医症候评分、观察两组治疗前后日常生活能力(ADL)、神经功能(NIHSS)、肢体运动功能(FMA)评分,观察两组治疗前后血清IL-33、VILIP-1水平,观察两组治疗后临床疗效以及不良反应发生情况。结果:治疗前,两组中医症候评分、ADL、NIHSS、FMA、NIHSS评分、血清IL-33、VILIP-1水平比较,差异无统计学意义(P>0.05); 治疗后,两组中医症候评分、NIHSS评分、IL-33、VILIP-1水平均低于治疗前(P<0.05),且观察组比对照组低(P<0.05); 治疗后,两组ADL、FMA评分均比治疗前高(P<0.05),且观察组高于对照组(P<0.05); 观察组治疗后的临床有效率比对照组高(P<0.05); 两组治疗期间不良反应发生率相近(P>0.05)。结论:对气虚血瘀型急性脑梗死患者采用保元汤合血府逐瘀汤治疗,可显著改善患者的临床症状,调节血清IL-33及VILIP-1的表达,改善患者的日常生活能力、神经功能以及肢体运动功能。
Abstract:
Objective:The effect of Baoyuan decoction and Xiefu Zhuyu decoction in treating acute cerebral infarction of Qi deficiency and blood stasis and its effects on interleukin-33(IL-33)and trypsin-like protein-1(VILIP-1)influences were explored.Methods:A total of 86 cases were selected and divided into a control group(treated by conventional methods)and an observation group(treated with Baoyuan decoction and Xiefu Zhuyu decoction on the basis of the control group)according to the random number table method,each group was 43 cases,both groups were treated for 1 month,observed the TCM symptom scores of the two groups before and after treatment,observed the ability of daily living(ADL),neurological function(NIHSS),and motor function(FMA)scores of the two groups before and after treatment,observed the serum IL-33 and VILIP-1 levels of the two groups before and after treatment.Observe the clinical efficacy and adverse reactions in the two groups after treatment.Results:Before treatment,there was no significant difference between the two groups of TCM syndrome scores,ADL,NIHSS,FMA,NIHSS scores,serum IL-33,and VILIP-1 levels(P>0.05); after treatment,the two groups of TCM syndrome scores,NIHSS scores,IL-33,and VILIP-1 levels were lower than before treatment(P<0.05),and the observation group was lower than the control group(P<0.05); after treatment,the ADL and FMA scores of the two groups were higher than before treatment(P <0.05),and the observation group was higher than the control group(P<0.05); the effective rate of clinical efficacy of the observation group after treatment was higher than that of the control group(P<0.05); the incidence of adverse reactions during the treatment period of the two groups was similar(P>0.05).Conclusion:For patients with acute cerebral infarction of Qi deficiency and blood stasis type,Baoyuan decoction and Xiefu Zhuyu decoction are used to treat patients with definite curative effect,which can significantly improve the clinical symptoms of patients,regulate the expression of serum IL-33 and VILIP-1,and improve the patients' ability of daily living,nerve function and motor function of limbs.

参考文献/References:

[1] 梁春玲,陈晓杰,刘祖发,等.补阳还五汤联合西药治疗急性脑梗死疗效及对患者血管斑块稳定性及血清因子水平的影响[J].陕西中医,2020,41(9):1200-1204.
[2] 蔡珍飞,吴肖萍,曹 丹.2017年台州地区急性脑梗死发生的流行特征[J].实用预防医学,2019,26(10):1247-1250.
[3] 吴明超,曹铭华,邹永周,等.急性脑梗死患者血浆同型半胱氨酸水平与叶酸需求基因多态性分析[J].中国急救复苏与灾害医学杂志,2020,15(12):1398-1401.
[4] 秦 锐,谢宏斌,苏 茜.神经节苷脂联合临床康复路径对急性脑梗死患者临床疗效、认知功能及神经功能的影响[J].疑难病杂志,2020,19(9):892-895.
[5] 尤晓涵,杨 淼,明霞光,等.盐酸川芎嗪注射液联合丁苯酞软胶囊治疗急性脑梗死疗效及对患者血液流变学影响[J].陕西中医,2020,41(6):743-745,757.
[6] 周爱民,杨德钱,赵凤林.保元汤合血府逐瘀汤对慢性心力衰竭患者心功能及炎性因子的影响[J].中国医药导报,2019,16(10):128-131.
[7] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国各类主要脑血管病诊断要点2019[J].中华神经科杂志,2019,52(9):710-715.
[8] 国家食品药品监督管理总局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:361-362.
[9] 袁山旗,赵红敏,张西安,等.机械支架介入取栓联合静脉溶栓治疗老年急性脑梗死临床疗效及对患者神经功能的影响[J].陕西医学杂志,2019,48(2):237-240,247.
[10] 陆俊杰,张 洋,张清清,等.经微导管注射替罗非班联合Solitaire支架取栓治疗急性脑梗死21例临床研究[J].陕西医学杂志,2019,48(6):740-743.
[11] 曾永青,陈晓霞,苏晓玉.补阳还五汤治疗急性脑梗死的疗效及对患者血清MMP-2、hs-CRP水平的影响[J].海南医学,2020,31(2):178-180.
[12] 王 骏,龚 帆,Joana S,等.rtPA溶栓24h内使用加味星蒌承气汤治疗急性脑梗死痰热腑实证的临床研究[J].中西医结合心脑血管病杂志,2020,18(17):2769-2773.
[13] 陈宗伟,沈志涛,郑振国,等.芪苈强心胶囊配合保元汤加减治疗慢性心力衰竭临床研究[J].陕西中医,2020,41(2):191-193.
[14] 冯 锦,张 瑛.真武汤合保元汤辅助西药治疗2型心肾综合征疗效及对ET-1、NO、炎性细胞因子水平的影响[J].中国中医急症,2019,28(1):119-122.
[15] 郭 义,林 俊.血府逐瘀汤通过影响BMP9表达抑制Notch信号通路调节髓核细胞增殖的机制[J].中国老年学杂志,2021,41(2):365-368.
[16] 李昕阳,刘素萍,王佳良,等.血府逐瘀汤联合针灸治疗缺血性脑卒中偏瘫患者的临床研究[J].中国医药导报,2020,17(5):137-140.
[17] 王 颖,陈 虎,吕 旺,等.血府逐瘀汤联合西药治疗慢性心力衰竭合并抑郁症血行郁滞证[J].吉林中医药,2020,40(2):201-204.
[18] 安 升.长春西汀联合丹红注射液治疗急性小脑梗死所致眩晕62例疗效观察[J].陕西医学杂志,2018,47(9):1196-1198.
[19] 董进军,商李超,李妍蓉,等.保元汤合血府逐瘀汤干预冠心病心力衰竭(气虚血瘀型)的临床观察[J].中西医结合心血管病电子杂志,2020,8(23):159.
[20] 黄英媛,杨国帅,宋振华.葛酮通络胶囊联合针灸对急性脑梗死病人血清VILIP-1、Cav-1表达的影响[J].中西医结合心脑血管病杂志,2020,18(22):3858-3861.
[21] 王琼芬,王 科,王风波,等.智三针联合头针治疗卒中后血管性认知障碍的疗效及对VILIP-1 、IGF-1水平影响[J].针灸临床杂志,2020,36(9):5-8.

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备注/Memo

备注/Memo:
基金项目:山东省医药卫生科技发展计划项目(2015WS0354)
更新日期/Last Update: 2021-05-10