[1]朱 宁,马晓珊,陈春丽,等.益智醒脑方对阿尔茨海默病大鼠学习记忆能力及炎症因子的影响[J].陕西中医,2021,(7):831-835.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.004]
　ZHU Ning,MA Xiaoshan,CHEN Chunli,et al.Effect of Yizhi Xingnao recipe on the learning and memory ability of Alzheimer's disease rats and on the levels of inflammatory factors[J].,2021,(7):831-835.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.004]
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益智醒脑方对阿尔茨海默病大鼠学习记忆能力及炎症因子的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年7期
页码:
831-835
栏目:
基础研究
出版日期:
2021-07-09

文章信息/Info

Title:
Effect of Yizhi Xingnao recipe on the learning and memory ability of Alzheimer's disease rats and on the levels of inflammatory factors
作者:
朱 宁; 马晓珊; 陈春丽; 陈 怡; 朱德康
(南方医科大学南海医院,广东 佛山 528244)
Author(s):
ZHU Ning; MA Xiaoshan; CHEN Chunli; CHEN Yi; ZHU Dekang
(Nanhai Hospital of Southern Medical University,Foshan 528244,China)
关键词:
阿尔茨海默病;  益智醒脑方;  大鼠;  学习记忆能力;  白介素-1β;  白介素-6;  肿瘤坏死因子-α
Keywords:
Alzheimer's disease;  Yizhi Xingnao recipe;  Rats;  Learning and memory ability;  Interleukin-1β;  Interleukin-6;  Tumor necrosis factor-α
分类号:
R 749.16
DOI:
DOI:10.3969/j.issn.1000-7369.2020.07.004
文献标志码:
A
摘要:
目的:评估益智醒脑方对阿尔茨海默病大鼠学习记忆能力及对白介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的影响。方法:将90只老年Wistar大鼠随机分为六组含高剂量益智醒脑方组(高剂量组)、中剂量益智醒脑方组(中剂量组)、低剂量益智醒脑方组(低剂量组)、正常组、模型组及西药组,每组15只,除了正常组其余各组均进行Aβ1-42造模制备成阿尔茨海默病大鼠。观察各组大鼠学习记忆力、海马APP、VPS35、SorLA的表达及海马炎症因子IL-1β、IL-6、TNF-α水平。结果:高剂量组及正常组穿越平台次数高于模型组、西药组、中剂量组及低剂量组,差异均有统计学意义(P<0.05); 高剂量组逃避潜伏期低于模型组、正常组、西药组、中剂量组及低剂量组,差异均有统计学意义(P<0.05)。正常组APP、VPS35、SorLA的表达均高于高剂量组、模型组、西药组、中剂量组及低剂量组,差异均有统计学意义(P<0.05)。正常组IL-1β、IL-6、TNF-α水平均低于高剂量组、模型组、西药组、中剂量组及低剂量组,差异均有统计学意义(P<0.05)。结论:益智醒脑方能够改善阿尔茨海默病大鼠学习记忆能力,降低IL-1β、IL-6、TNF-α水平。
Abstract:
Objective:To evaluate the effects of Yizhi Xingnao recipe on the learning and memory abilities of Alzheimer's disease rats and the levels of Interleukin-1β(IL-1β),Interleukin-6(IL-6)and Tumor necrosis factor-α(TNF-α).Methods:90 aged Wistar rats were randomly divided into 6 groups including high-dose Yizhi Xingnao recipe group(high-dose group),medium-dose Yizhi Xingnao recipe group(medium-dose group),and low-dose Yizhi Xingnao recipe group(low-dose group),normal group,model group and western medicine group,15 rats in each group,except for the normal group,all other groups were modeled with Aβ1-42 to prepare Alzheimer's disease rats.The learning and memory ability,the expression of hippocampal APP,VPS35,SorLA and the levels of hippocampal inflammatory factors IL-1β,IL-6,and TNF-α were observed in each group of rats.Results:The frequency of crossing the platform in high-dose group and normal group was higher than that in model group,western medicine group,medium-dose group and low-dose group,and the difference was statistically significant(P<0.05).The escape latency of high-dose group was lower than those in model group,normal group,western medicine group,medium-dose group and low-dose group,and the difference was statistically significant(P<0.05).The expressions of APP,VPS35 and SorLA in normal group were higher than those in high-dose group,model group,western medicine group,medium-dose group and low-dose group,with statistical significance(P<0.05).The levels of IL-1β,IL-6 and TNF-α in normal group were lower than those in high-dose group,model group,western medicine group,medium-dose group and low-dose group,with statistical significance(P<0.05).Conclusion:Yizhi Xingnao recipe can improve the learning and memory ability of Alzheimer's disease rats,and reduce the levels of IL-1β,IL-6 and TNF-α.

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备注/Memo

备注/Memo:
基金项目:广东省自然科学基金资助项目(2018030310289)
更新日期/Last Update: 2021-07-07