[1]秦 魏,邢 露,杨智慧,等.丹参活性成分在抗动脉粥样硬化中的作用与机制研究进展[J].陕西中医,2021,(7):977-979.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.044]
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丹参活性成分在抗动脉粥样硬化中的作用与机制研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年7期
页码:
977-979
栏目:
综 述
出版日期:
2021-07-09

文章信息/Info

作者:
秦 魏1邢 露1杨智慧1贾礼伊2 靳 洁2郭 蒙2孙晓莹2曹慧玲12
(1.西安医学院基础与转化医学研究所 陕西省缺血性心血管疾病重点实验室,陕西 西安 710021; 2.陕西中医药大学药学院,陕西 咸阳 712046)
关键词:
动脉粥样硬化 丹参 丹酚酸B 丹酚酸A 丹参酮Ⅱ A 隐丹参酮
分类号:
R 541.4
DOI:
DOI:10.3969/j.issn.1000-7369.2020.07.044
文献标志码:
A
摘要:
心脑血管疾病是全球人类首要致死因素,动脉粥样硬化(As)是其主要病理基础。As发病机制复杂,临床使用的化学药物疗效单一,价格昂贵,不良反应较大。作用靶点多、不良反应少、价廉易得的中草药已成为防治心脑血管疾病的研究热点,丹参作为代表药物在As防治方面具有独特作用。该文章从中医与As关系以及丹参主要有效组分抗As活性方面,综述了丹参抗As的药理学研究进展,重点介绍了其水溶性组分丹酚酸B和丹酚酸A、脂溶性组分丹参酮ⅡA和隐丹参酮抗As活性与作用机制,以期为丹参抗As应用提供参考。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(31700699); 陕西省科技厅社发统筹重点项目(2017ZDXM-SF-029); 陕西省教育厅重点项目(17JS118)
更新日期/Last Update: 2021-07-07