[1]刘 健,加拉力丁·买买提,董新玲,等.益气活血方治疗冠心病不稳定型心绞痛临床研究[J].陕西中医,2021,(8):1037-1040.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.012]
　LIU Jian,GALALIDIN Maimat,DONG Xinling,et al.Therapeutic effect of Yiqi Huoxie decoction in treating coronary heart disease and its effect on patients' serum sICAM-1,ET and NO[J].,2021,(8):1037-1040.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.012]
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益气活血方治疗冠心病不稳定型心绞痛临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年8期
页码:
1037-1040
栏目:
临床研究
出版日期:
2021-08-05

文章信息/Info

Title:
Therapeutic effect of Yiqi Huoxie decoction in treating coronary heart disease and its effect on patients' serum sICAM-1,ET and NO
作者:
刘 健1; 加拉力丁·买买提1; 董新玲1; 冷 静1; 王晓峰2
(1.新疆医科大学第二附属医院,新疆 乌鲁木齐 830000; 2.新疆维吾尔自治区中医医院,新疆 乌鲁木齐 830099)
Author(s):
LIU Jian; GALALIDIN Maimat; DONG Xinling; LENG Jing; WANG Xiaofeng
(Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)
关键词:
冠心病不稳定型心绞痛;  血瘀证;  益气活血方;  血清可溶性细胞间黏附分子1;  内皮素;  一氧化氮
Keywords:
Unstable angina pectoris of coronary heart disease;  Blood stasis syndrome;  Yiqi Huoxie decoction;  Serum soluble intercellular adhesion molecule 1;  Endothelin;  Nitric oxide
分类号:
R 541.4
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.012
文献标志码:
A
摘要:
目的:探讨益气活血方治疗冠心病不稳定型心绞痛血瘀证疗效及对患者血清可溶性细胞间黏附分子1(sICAM-1)、内皮素(ET)、一氧化氮(NO)的影响。方法:选择104例冠心病不稳定型心绞痛血瘀证患者为研究对象,随机分为对照组和观察组各52例。对照组采用常规方案治疗,观察组在对照组的基础上采用益气活血方治疗,两组均治疗4周。观察两组治疗前后中医症候评分、血清sICAM-1、ET、NO水平,比较两组硝酸甘油停减率、心电图改善情况、中医症候疗效以及治疗期间不良反应发生情况。结果:两组患者治疗后血瘀证中医症状评分、血清sICAM-1、ET水平均降低(P<0.05),且观察组更低(P<0.05); 观察组硝酸甘油停减率比对照组高(88.46%与69.23%,P<0.05); 两组心电图改善总有效率相近(P>0.05); 两组治疗后血清NO水平均升高(P<0.05),且观察组更高(P<0.05); 观察组中医症候总有效率比对照组高(90.38%与75.00%,P<0.05); 两组治疗期间不良反应发生率相近(P>0.05)。结论:益气活血方联合常规方案治疗冠心病不稳定型心绞痛血瘀证患者,可改善患者的临床症状,疗效显著,提高硝酸甘油停减率,改善血管内皮功能。
Abstract:
Objective:To investigate the therapeutic effect of Yiqi Huoxie decoction on unstable angina pectoris and blood stasis syndrome of coronary heart disease and its effect on serum soluble intercellular adhesion molecule 1(sICAM-1),endothelin(ET)and nitric oxide(NO).Methods:A total of 104 patients with unstable angina pectoris and blood stasis syndrome of coronary heart disease were selected as the research objects,and they were divided into control group and observation group with 52 cases in each group by random number table.The control group was treated with the conventional regimen,and the observation group was treated with Yiqi Huoxie decoction on the basis of the control group.Both groups were treated for 4 weeks.The TCM syndrome scores,serum sICAM-1,ET,and NO levels before and after treatment in the two groups were observed,and compared the nitroglycerin stop rate,electrocardiogram improvement,TCM syndrome efficacy and adverse reactions during the treatment period.Results:After treatment,the TCM symptom scores,serum sICAM-1 and ET levels of the two groups of patients with blood stasis syndrome decreased(P<0.05),and the observation group was even lower(P<0.05).The reduction rate of nitroglycerin in the observation group was higher than that in the control group(88.46% vs. 69.23%,P<0.05).The total effective rate of the two groups of electrocardiogram improvement is similar(P>0.05).Serum NO levels in the two groups increased after treatment(P<0.05),and higher in the observation group(P<0.05).The total effective rate of TCM symptoms in the observation group was higher than that in the control group(90.38% vs. 75.00%,P<0.05).The incidence of adverse reactions during the treatment period of the two groups was similar(P>0.05).Conclusion:Yiqi Huoxie decoction combined with conventional regimens can improve the clinical symptoms of patients with unstable angina pectoris and blood stasis syndrome,improve the patient's clinical symptoms,increase the rate of nitroglycerin arrest,improve vascular endothelial function.

参考文献/References:

[1] Puelacher C,Gugala M,Adamson PD,et al.Incidence and outcomes of unstable angina compared with non-ST-elevation myocardial infarction[J].Heart,2019,105(18):1423-1431.
[2] Yang L,Song L,Ma D,et al.Plasma S100A4 level and cardiovascular risk in patients with unstable angina pectoris[J].Biomark Med,2019,13(17):1459-1467.
[3] 王 娜,杨 琳.薤白通脉汤加减对冠心病不稳定型心绞痛患者中医证候积分及血清VEGF、Hcy水平的干预作用[J].陕西中医,2020,41(10):1388-1391.
[4] 贺小芳,唐蓓蕾,王 显,等.益气活血利水方治疗冠心病心力衰竭气虚血瘀水饮证患者疗效分析[J].现代中医临床,2020,27(3):9-12.
[5] 谭忠伦.加味益气降浊汤联合丹红注射液对痰阻心脉证冠心病不稳定型心绞痛患者心电图变化以及血清TIMP-1、sICAM-1水平变化的影响[J].中国医药导刊,2019,21(2):90-94.
[6] 赵 亮,宫丽鸿.复方稳斑汤联合体外反搏治疗对冠心病不稳定型心绞痛病人临床疗效及对血清一氧化氮和血管内皮素-1的影响[J].中西医结合心脑血管病杂志,2017,15(18):2228-2231.
[7] 龚 洁.冠心病防治指南[M].武汉:湖北科学技术出版社,2012:68-70.
[8] 中华医学会心血管分会,中华心血管病编辑委员会.不稳定型心绞痛诊断和治疗建议[J].中华心血管病杂志,2000,28(6):409-412.
[9] 中华中医药学会内科分会心病专业委员会.中医心病之心绞痛诊断与疗效标准[J].中国医药学报,2004,19(10):581-583.
[10] 国家食品药品监督管理总局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:258-259.
[11] 刘羿妍,李浦媛,李晟琰,等.参芍胶囊治疗冠心病不稳定型心绞痛的临床观察[J].中国药房,2017,28(11):1541-1544.
[12] 颜世辉.不同抗血小板方案在冠心病患者中应用对心血管事件的预防作用分析[J].中国现代医生,2017,55(8):106-109.
[13] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1999:158-159.
[14] 罗 薇,韩 勇,王莉萍,等.西地兰联合贝那普利对老年冠心病心力衰竭患者心功能及金属蛋白酶组织抑制因子-4、游离脂肪酸表达的影响[J].陕西医学杂志,2021,50(2):216-220.
[15] 董 昕,杨朋康.单硝酸异山梨酯联合维拉帕米对冠心病稳定型心绞痛患者血脂水平及血清同型半胱氨酸、高敏C反应蛋白的影响[J].陕西医学杂志,2020,49(4):485-488.
[16] 朱永栋,董红建,朱林燕,等.清心活血消瘀方治疗冠心病合并高血压的临床研究[J].中国急救复苏与灾害医学杂志,2020,15(1):27-28.
[17] 禹海文,党瑜华,董炎炎.大株红景天注射液联合回阳升陷汤治疗不稳定型心绞痛临床疗效及对患者炎症因子的影响[J].陕西中医,2020,41(1):32-34.
[18] 杨 洋,王建新,孟家瑞,等.自拟益气活血温阳利水方联合美托洛尔对心力衰竭患者心功能的影响[J].中国药业,2021,30(1):76-79.
[19] 陈 媛,林尤斌,吴清柳,等.冠心丹参滴丸对老年冠状动脉粥样硬化性心脏病不稳定型心绞痛患者血小板活化功能及血清MMP-9、sICAM-1及tPAI-1水平的影响[J].世界临床药物,2020,41(2):111-117.
[20] 吕 琴,赵文晓,王世军,等.黄芪活血功效及现代药理学研究进展[J].中国实验方剂学杂志,2020,26(9):215-224.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81760794)
更新日期/Last Update: 2021-08-09