[1]张瑞华,张静文,刘 玲,等.黄芪及其有效组分药理作用与临床应用现状[J].陕西中医,2021,(8):1138-1141,1146.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.037]
　ZHANG Ruihua,ZHANG Jingwen,LIU Ling,et al.The pharmacological effects and current situation of clinical application of Astragalus and its effective components[J].,2021,(8):1138-1141,1146.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.037]
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黄芪及其有效组分药理作用与临床应用现状
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年8期
页码:
1138-1141,1146
栏目:
综 述
出版日期:
2021-08-05

文章信息/Info

Title:
The pharmacological effects and current situation of clinical application of Astragalus and its effective components
作者:
张瑞华; 张静文; 刘 玲; 石 勇; 钞 婷; 王 川; 王 斌; Abdulmalik Koya(尼日利亚); 刘继平
(陕西中医药大学药学院,陕西 咸阳 712046)
Author(s):
ZHANG Ruihua; ZHANG Jingwen; LIU Ling; SHI Yong; CHAO Ting; WANG Chuan; WANG Bin; Abdulmalik Koya; LIU Jiping
(College of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China)
关键词:
黄芪;  黄芪多糖;  黄芪总黄酮;  黄芪甲苷;  免疫调节;  药理作用
Keywords:
Astragalus;  Astragalus polysaccharide;  Total flavonoids of astragalus;  Astragaloside;  Immune regulation;  Pharmacological effects
分类号:
R 285
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.037
文献标志码:
A
摘要:
黄芪从古至今应用广泛,现代药理研究证明其主要有效组分黄芪多糖、黄芪总黄酮、黄芪甲苷等具有保护心血管、调节免疫、抗肿瘤、抗氧化应激、改善代谢等作用。疾病的发生多与免疫系统相关,而作为补气中药,黄芪对免疫系统有更大贡献。不仅单用有效,与西药及现代医学技术联用更能呈现出提高机体抗病原体能力。如抗肿瘤的免疫疗法及维持机体免疫平衡环境免受外界刺激带来的损害,这正体现了中医“扶正”的理念。在临床应用上,黄芪注射液的开发为更多疾病的治疗提供可能性。另有学者已开展了黄芪纳米粒干预脓毒症小鼠的基础研究。这暗示中药潜在的临床价值建立在改进治疗手段和开发新型制剂上。现对近几年黄芪及其组分的药理作用和临床应用现状进行总结,以期为黄芪临床应用开发提供新的研究思路和科学依据。
Abstract:
Astragalus has been widely used since ancient times.Modern pharmacological studies have proved that its main components,Astragalus polysaccharides,total flavonoids of Astragalus,Astragaloside can protect the cardiovascular system,regulate immunity,fight tumors,resist oxidative stress,improve metabolism and so on.Dieases occurance has relationships with immune system closely.As Chinese medicine for invigorating Qi,Astragalus has a greater contribution to the immune system.Not only is it practical for single-use,but it also shows how it can improve the body's ability to resist pathogens when used in combination with western medicine and morden medical technology.Such as anti-tumor immunotherapy and maintaining the body's immune balance environment from damage caused by external stimuli embodies the concept of “strengthening the body” of Chinese medicine.In clinical application,the development of Astragalus injection has provided more possibilities for more diseases.Other scholars have carried out fundamental research on the intervention of Astragalus nanoparticles in mice with sepsis.This implies that the potential clinical needs of traditional Chinese medicine are based on improving treatment methods and developing new formulations.This article comprehensive summarizes the pharmacological effects and clinical application status of Astragalus and its effective components in recent years,hoping to provide new research ideas and a scientific basis for the clinical application and development of Astragalus.

参考文献/References:

[1] 赵 岩,杨 丹,于珊珊.黄芪甲苷对慢性心力衰竭大鼠心肌细胞凋亡及P-Cx43表达水平的影响[J].临床和实验医学杂志,2018,17(20):2143-2147.
[2] 张石在,刘天龙,张铭杰,等.黄芪三萜皂苷通过抑制CVB3诱导的心肌细胞凋亡保护病毒性心肌炎小鼠的心肌损伤[J].中国分子心脏病学杂志,2019,19(2):2856-2860.
[3] 姜 帅.黄芪多糖对游离脂肪酸所致人血管内皮细胞NLRP3炎性小体表达的影响[J].陕西中医,2019,40(9):1165-1169,1314.
[4] 杜 芳,董立江.黄芪多糖抑制人肝癌细胞增殖的作用机制研究[J].华西药学杂志,2020,35(4):402-406.
[5] 王禹璇,刘海英,姚 红,等.中药黄芪蛋白抗肝癌细胞HepG2作用机制[J].药学学报,2020,55(2):241-246.
[6] 曹 松,严晓燕,马 军,等.黄芪多糖调控细胞DNA损伤修复发挥抗非小细胞肺癌活性的机制研究[J].药物评价研究,2020,43(6):1051-1058.
[7] 杨 冰,于桂红,李明雨,等.基于“补气固表”探究黄芪黄酮组分抑制C57BL/6荷瘤小鼠肿瘤生长及免疫调节机制研究[J].中国中药杂志,2019,44(23):5184-5190.
[8] 王莉新,吴文斌,胥孜杭,等.黄芪甲苷通过诱导M1型巨噬细胞极化发挥抗肿瘤作用的机制[J].中国实验方剂学杂志,2019,25(14):19-24.
[9] 刘 慧.黄芪糖蛋白对CIA模型小鼠Th17/Treg细胞平衡的影响及机制研究[D].北京:北京中医药大学,2017.
[10] 王 頔,唐桥斐,姜玉秋,等.PD-L1对过敏性鼻炎小鼠Treg/Th17细胞免疫失衡调节作用研究[J].陕西医学杂志,2018,47(3):287-291.
[11] 邢发萍,杨 柳,韩欣研,等.黄芪提取物抑制小鼠实验性自身免疫性脑脊髓炎的作用及机制[J].中国药理学与毒理学杂志,2019,33(11):941-948.
[12] Li W,Hu X,Wang S,et al.Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation[J].International Journal of Biological Macromolecules,2020(145):985-987.
[13] 王 萌,郭 泽,周鸿缘,等.黄芪总黄酮对巨噬细胞RAW264.7抗炎免疫的双向调节研究[J].中国预防兽医学报,2020,42(8):822-829.
[14] 周鸿缘,张 贤,王 萌,等.黄芪总黄酮体外抗炎作用及对MAPKs信号通路的调控[J].中国兽医学报,2020,40(12):2392-2397.
[15] 赵启跃,姚 遥,郑 萍,等.黄芪甲苷对阿尔茨海默症小鼠脑内氧化应激和NADPH氧化酶蛋白表达的影响[J].宁夏医科大学学报,2018,40(11):1241-1244,1249.
[16] 靳晓飞,张彐宁,周晓红,等.黄芪甲苷调控自噬减轻氧糖剥夺/复氧复糖PC12细胞氧化应激损伤研究[J].中国药理学通报,2020,36(1):53-58.
[17] 雷 玲,闵 珺,刘 锋,等.黄芪对肝纤维化大鼠肝损伤保护作用及机制研究[J].陕西中医,2020,41(9):1192-1196.
[18] 马可可,鞠营辉,陈清青,等.黄芪甲苷对2型糖尿病肾病大鼠肾组织PI3K/Akt/FoxO1信号调控的影响[J].中国实验方剂学杂志,2019,25(2):74-81.
[19] 张艳丽,万 凤,田 沫,等.黄芪甲苷上调HIF-1α表达促进氧糖剥夺/再灌注胚鼠海马神经干细胞增殖和分化的作用[J].中华中医药杂志,2020,35(7):3358-3362.
[20] 叶 妮,马金昀,程晓东.黄芪多糖对C17.2神经干细胞定向分化的调控作用[J].世界中医药,2019,14(10):2598-2602,2608.
[21] 徐 进,郑 璟,严力军.黄芪多糖下调骨肉瘤细胞对阿霉素耐药的可能机制研究[J].中国中医骨伤科杂志,2020,28(11):6-9.
[22] 李 佳,吴建林.病毒性心肌炎的中医用药规律及病机分析[J].江苏中医药,2017,49(6):70-72.
[23] 杜建慧.黄芪注射液联合注射用磷酸肌酸钠治疗病毒性心肌炎患儿的临床效果[J].中华心脏与心律电子杂志,2019,7(2):89-91.
[24] 王赖儿,鱼天英,任彦林.黄芪注射液联合曲美他嗪治疗小儿急性病毒性心肌炎中作用分析[J].山西医药杂志,2020,49(8):975-977.
[25] 陈昱林,莫雪妮,梁国隆,等.黄芪注射液治疗轻中度阿尔茨海默病临床观察[J].亚太传统医药,2020,16(11):136-137.
[26] 杨军锋.黄芪注射液联合丁苯酞软胶囊对血管性痴呆患者认知功能及生活能力的影响[J].实用中西医结合临床,2018,18(1):56-57.
[27] 董 华.黄芪总苷和MK-801对宫内窘迫后认知障碍的作用[J].中国医院药学杂志,2017,37(18):1823-1826,1846.
[28] 李建娣,俞维英.黄芪注射液辅助治疗对卵巢癌患者的治疗效果及对患者生活质量、炎症因子、T淋巴细胞的影响[J].新中医,2019,51(8):194-196.
[29] 郝珊瑚,纪立秋,王治国,等.黄芪注射液联合131I核素治疗分化型甲状腺癌临床研究[J].西部中医药,2020,33(3):97-100.
[30] 张树聪,蔡治祥,王学涛,等.黄芪多糖对人鼻咽癌CNE-1细胞的放疗增敏及上皮间质转化的作用[J].中国实验方剂学杂志,2020,26(20):59-66.
[31] 张 乔,李 静,张 琦,等.黄芪、苦参、皂角刺抗肝癌作用的比较研究[J].中医药信息,2020,37(1):48-54.
[32] 陈 霞,张国尊,刘莹莹,等.巨噬细胞与肝癌转移及临床预后关系研究[J].陕西医学杂志,2018,47(3):292-294,298.
[33] 陈 腾,王 之,王丹丽,等.黄芪治疗糖尿病肾病临床疗效及对尿足细胞标志蛋白影响[J].中国中西医结合肾病杂志,2019,20(8):694-696.
[34] 刘 岐.黄芪注射液穴位注射辅助治疗糖尿病性下肢动脉硬化闭塞症的临床观察[D].哈尔滨:黑龙江中医药大学,2019.
[35] 李 晓,马振卉,王园园,等.黄芪注射液对人角质细胞增殖和黏附功能的影响及其治疗银屑病的作用机制[J].吉林大学学报:医学版,2020,46(6):1202-1207.
[36] 沈立飞,王海英.黄芪注射液联合阿维A、复方氟米松软膏对银屑病患者外周血细胞因子的影响[J].中国老年学杂志,2016,36(14):3546-3547.
[37] 张会文.重用黄芪救治狼疮性肾炎患者1例[J].中国中医急症,2015,24(2):372-373,376.
[38] 李倩倩,周 佳,谭祖教,等.论治系统性红斑狼疮慎用人参、黄芪[J].中华中医药杂志,2019,34(9):4145-4147.
[39] Xu X,Rui S,Chen C,et al.Protective effects of astragalus polysaccharide nanoparticles on septic cardiac dysfunction through inhibition of TLR4/NF-κB signaling pathway[J].International Journal of Biological Macromolecules,2020(153):977-985.

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　WANG Jili,ZHAO Yanlong..Analysis of planting related factors affecting polysaccharide content of Astragalus[J].,2019,(8):1803.
[2]雷 玲,闵 珺,刘 锋,等.黄芪对肝纤维化大鼠肝损伤保护作用及机制研究*[J].陕西中医,2020,(9):1192.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.004]
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备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年基金资助项目(81800401); 陕西省中医药管理局中医药科研项目(ZYPT002); 陕西中医药大学学科创新团队项目(2019-YL13); 陕西省中医药管理局中药药效机制与物质基础重点研究室建设项目
更新日期/Last Update: 2021-08-09