[1]吴金兰,马 岚,张 丽.补肾安胎饮加减联合穴位贴敷治疗先兆流产疗效及对患者血清β-HCG、孕酮、雌二醇的影响[J].陕西中医,2021,(9):1193-1196.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.010]
　WU Jinlan,MA Lan,ZHANG Li.Clinical effect of modified Bushen Antai decoction combined with acupoint application in threatened abortion and influence on serum β-HCG,progesterone and estradiol[J].,2021,(9):1193-1196.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.010]
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补肾安胎饮加减联合穴位贴敷治疗先兆流产疗效及对患者血清β-HCG、孕酮、雌二醇的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年9期
页码:
1193-1196
栏目:
临床研究
出版日期:
2021-09-05

文章信息/Info

Title:
Clinical effect of modified Bushen Antai decoction combined with acupoint application in threatened abortion and influence on serum β-HCG,progesterone and estradiol
作者:
吴金兰; 马 岚; 张 丽
(芜湖市中医医院产科,安徽 芜湖 241000)
Author(s):
WU Jinlan; MA Lan; ZHANG Li
(Department of Obstetrics,Wuhu Hospital of Traditional Chinese Medicine,Wuhu 241000,China)
关键词:
先兆流产;  脾肾两虚证;  补肾安胎饮;  穴位贴敷;  人绒毛膜促性腺激素;  孕酮;  雌二醇
Keywords:
Threatened abortion;  Pishen Liangxu syndrome;  Bushen Antai decoction;  Acupoint application;  Human chorionic gonadotropin;  Progesterone;  Estradiol
分类号:
R 271.4
DOI:
DOI:10.3969/j.issn.1000-7369.2020.09.010
文献标志码:
A
摘要:
目的:研究补肾安胎饮加减联合穴位贴敷治疗先兆流产的临床疗效及对血清β-绒毛膜促性腺激素(β-HCG)、孕酮(P)、雌二醇(E2)的影响。方法:以随机数字表法将110例先兆流产脾肾两虚证患者分为联合组(56例)和对照组(54例)。联合组给予补肾安胎饮加减联合穴位贴敷及西药治疗,对照组给予西药治疗。比较两组患者治疗前后子宫螺旋动脉血流动力学[收缩期峰值血流(PSV)、舒张末期流速(EDV)和阻力指数(RI)]、炎症因子[γ-干扰素(INF-γ)、白细胞介素-2(IL-2)、IL-4]和血清β-HCG、P、E2水平及中医证候积分变化,评估疗效。结果:联合组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,联合组患者PSV、EDV水平和血清IL-4、β-HCG、P、E2水平高于对照组,RI、INF-γ、IL-2水平和中医证候积分低于对照组(均P<0.05)。结论:补肾安胎饮加减联合穴位贴敷及西药治疗先兆流产脾肾两虚证,可调节炎症因子、子宫螺旋动脉血流动力学水平,明显改善血清β-HCG、P、E2水平及患者症状。
Abstract:
Objective:The purpose of the study was to study the clinical effect of modified Bushen Antai decoction combined with acupoint application in adjuvant treatment of threatened abortion,and the influence on serum β-human chorionic gonadotropin(β-HCG),progesterone(P)and estradiol(E2).Methods:110 patients with acupoint application of Pishen Liangxu syndrome were divided into combination group(56 cases)and control group(54 cases)by random number table method.Patients in the combination group were treated with modified Bushen Antai decoction combined with acupoint application based on western medicine treatment,while the control group were treated with western medicine.Uterine spiral artery hemodynamics[peak systolic velocity(PSV),end-diastolic velocity(EDV)and resistance index(RI)],inflammatory factors[interferon-γ(INF-γ),interleukin-2(IL-2)and IL-4],serum β-HCG,P,E2 levels and TCM syndrome scores were compared between the two groups.The curative effect was evaluated.Results:Total effective rate in the combination group was significantly higher than that in the control group(P<0.05).After treatment,PSV,EDV,serum IL-4,β-HCG,P and E2 levels in the combination group were significantly increased,and higher than those in the control group.RI,INF-γ,IL-2 and TCM syndrome scores were significantly decreased,and lower than those in the control group(all P<0.05).Conclusion:Applying modified Bushen Antai decoction combined with acupoint application based on western medicine to treat patients with acupoint application of Pishen Liangxu syndrome can regulate levels of inflammatory factors and uterine spiral artery hemodynamicsand,significantly improve levels of serum β-HCG,P and E2,thus promoting the improvement of symptoms.

参考文献/References:

[1] 刘德广,马红丽,王 宇,等.先兆流产治疗的研究进展[J].中国医药导报,2019,16(5):30-33.
[2] 王安妮,冯 欣,赵志刚.先兆流产药物治疗策略进展[J].临床药物治疗杂志,2019,17(2):32-35.
[3] 赵金青,陈玉荣.滋肾育胎丸联合黄体酮对高龄二胎先兆流产孕妇血清性激素及妊娠结局的影响[J].陕西中医,2017,38(12):1695-1696.
[4] 毛燕舞,徐素君,徐晓敏,等.中药内服外敷对肾虚型早期先兆流产患者性激素水平及短期妊娠预后的影响[J].上海中医药杂志,2018,52(3):58-61.
[5] 郑晓霞,舒 景,康永茂.阴道超声结合CA125、P、E2、β-HCG检测对先兆流产的临床意义[J].长春中医药大学学报,2016,32(2):185-186.
[6] 谢 幸.妇产科学[M].北京:人民卫生出版社,2013:47,108.
[7] 国家中医药管理局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:253-258.
[8] 谈 勇.中医妇科学[M].北京:中国中医药出版社,2016:154-160.
[9] 尚惠祁,李海涛.玉门市东乡族孕妇先兆流产影响因素的研究[J].中国急救医学,2016,36(z1):132-133.
[10] 王东梅,王 宪,李伟莉,等.胎动不安中医诊疗指南临床应用评价研究[J].中华中医药杂志,2016,31(4):194-196.
[11] 尹 鑫,刘 文.自拟健脾补肾养血安胎汤联合左甲状腺素钠片治疗孕早期先兆流产合并亚临床甲状腺功能减退症的价值评估[J].中国急救医学,2018,38(z1):81.
[12] 王 芬,田丽颖,顿巨燕.自拟固肾育胎方加减内服结合穴位贴敷治疗肾虚型早期先兆流产25例[J].安徽中医药大学学报,2020,39(4):34-37.
[13] 穆晓荣,李玲俐.血清孕酮联合子宫螺旋动脉血流检测对先兆流产妊娠结局的预测作用[J].中国计划生育学杂志,2018,26(3):202-205.
[14] 董胜雯,郭 洁.子宫螺旋动脉重铸与病理妊娠[J].国际妇产科学杂志,2017,44(2):176-179.
[15] 吴林玲,闫 颖,陈婉珍,等.先兆流产患者阴道微生态与局部免疫Th1/Th2失衡研究[J].中国妇幼保健,2019,34(16):3748-3751.
[16] 韩春艳,孙自学,宋艳丽.补肾安胎饮对肾虚型不明原因复发性流产患者的临床疗效[J].中成药,2019,41(12):3067-3071.
[17] 李柯狄.经阴道彩色多普勒超声联合血清E2、β-HCG早期预测妊娠结局价值研究[J].陕西医学杂志,2020,49(6):732-735.
[18] 米艳荣,李晓倩,张会保,等.血清P、β-HCG、E2水平联合经阴道B超预测先兆流产安胎结局的意义[J].中国性科学,2020,29(11):82-85.
[19] 徐 洁,肖 明.补肾益气安胎饮对先兆流产的临床观察及对患者免疫调节的影响[J].世界中西医结合杂志,2019,14(3):122-124,128.
[20] 郑 娜,王 婷,杨丽娟.补肾固胎膏穴位贴敷对肾虚型早期先兆流产患者血清性激素水平及细胞因子的影响[J].中国医药导报,2020,17(29):87-90.

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备注/Memo

备注/Memo:
基金项目:安徽省卫生和计划生育委员会中医药科研项目(2014ZY58)
更新日期/Last Update: 2021-09-10