[1]吴金波,佟 颖.化湿泄浊祛瘀汤联合别嘌醇对尿酸性肾病患者肾功能及氧化应激的影响[J].陕西中医,2021,(12):1724-1727.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.018]
　WU Jinbo,TONG Ying.Effect of Huashi Xiezhuo Quyu decoction combined with allopurinol on renal function and oxidative stress in patients with uric acid nephropathy[J].,2021,(12):1724-1727.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.018]
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化湿泄浊祛瘀汤联合别嘌醇对尿酸性肾病患者肾功能及氧化应激的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年12期
页码:
1724-1727
栏目:
临床研究
出版日期:
2021-12-05

文章信息/Info

Title:
Effect of Huashi Xiezhuo Quyu decoction combined with allopurinol on renal function and oxidative stress in patients with uric acid nephropathy
作者:
吴金波1; 佟 颖2
(1.黑龙江中医药大学,黑龙江 哈尔滨 150040; 2.黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040)
Author(s):
WU Jinbo; TONG Ying
(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
关键词:
尿酸性肾病;  化湿泄浊祛瘀汤;  别嘌醇;  肾功能;  氧化应激;  不良反应
Keywords:
Uric acid nephropathy;  Huashi Xiezhuo Quyu decoction;  Allopurinol;  Renal function;  Oxidative stress;  Adverse reactions
分类号:
R 692
DOI:
DOI:10.3969/j.issn.1000-7369.2020.12.018
文献标志码:
A
摘要:
目的:研究化湿泄浊祛瘀汤联合别嘌醇对尿酸性肾病患者肾功能及氧化应激的影响。方法:选择120例尿酸性肾病患者作为研究对象,采用随机数字表法将其分为观察组(n=60)和对照组(n=60)。对照组予别嘌醇进行治疗,观察组在对照组的基础上加用化湿泄浊祛瘀汤。观察两组临床疗效、不良反应发生情况,记录两组治疗前和治疗后4周中医证候积分、肾功能相关指标水平和氧化应激指标水平。结果:观察组治疗总有效率86.67%高于对照组的68.33%,差异有统计学意义(P<0.05)。治疗后,两组各项中医证候积分均有所降低,且观察组各项中医证候积分均低于对照组,差异有统计学意义(均P<0.05)。治疗后,两组UAER、BUN、SCr、SUA水平均下降,且观察组UAER、BUN、SCr、SUA水平均低于对照组,差异有统计学意义(均P<0.05)。治疗后,两组TAOC、SOD水平有所提高,AOPP、MDA水平有所降低,差异有统计学意义(P<0.05)。治疗后,观察组TAOC、SOD水平高于对照组,AOPP、MDA水平低于对照组,差异有统计学意义(均P<0.05)。结论:化湿泄浊祛瘀汤联合别嘌醇治疗尿酸性肾病患者疗效较好,可有效改善患者临床症状、保护肾功能、抑制氧化应激反应。
Abstract:
Objective:To study the effect of Huashi Xiezhuo Quyu decoction combined with allopurinol on renal function and oxidative stress in patients with uric acid nephropathy.Methods:120 patients with uric acid nephropathy were selected as the research objects.They were randomly divided into the observation group(n=60)and the control group(n=60).The control group was treated with allopurinol,and the observation group treated with Huashi Xiezhuo Quyu decoction on the basis of the control group.The clinical efficacy and adverse reactions of the two groups were observed.TCM symptom score,renal function related index levels,oxidative stress index level were recorded before and 4 weeks after treatment.Results:The total effective rate of the observation group 86.67% was higher than that of the control group 68.33%,difference statistically significant(P<0.05).After treatment,the TCM syndrome scores of the two groups were decreased,and the TCM syndrome scores of the observation group were lower than those in the control group,difference statistically significant(all P<0.05).After treatment,the levels of UAER,BUN,SCR and SUA in the two groups were decreased,and the levels of UAER,BUN,SCR and SUA in the observation group were lower than those in the control group(all P<0.05).After treatment,the levels of TAOC and SOD in the two groups were increased and AOPP,MDA decreased,difference statistically significant(P<0.05).The levels of TAOC and SOD in the observation group were higher and AOPP and MDA were lower than those in the observasion group,difference statistically significant(all P<0.05).Conclusion:Huashi Xiezhuo Quyu decoction combined with allopurinol has good curative effect in the treatment of patients with uric acid nephropathy.It can effectively improve clinical symptoms,protect the renal function and inhibit the oxidative stress reaction.

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备注/Memo

备注/Memo:
基金项目:黑龙江省自然科学基金资助项目(LH2019H115)
更新日期/Last Update: 2021-12-09