[1]张春玲,马 颖,孙仲函,等.芪地膝黄桂苓汤治疗慢性盆腔炎疗效及对患者炎性因子和免疫功能的影响[J].陕西中医,2022,(1):41-44.[doi:DOI:10.3969/j.issn.1000-7369.2022.01.009]
　ZHANG Chunling,MA Ying,SUN Zhonghan,et al.Qidixihuang Guiling decoction on chronic pelvic inflammation and its influence on inflammatory factors and immune function[J].,2022,(1):41-44.[doi:DOI:10.3969/j.issn.1000-7369.2022.01.009]
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芪地膝黄桂苓汤治疗慢性盆腔炎疗效及对患者炎性因子和免疫功能的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年1期
页码:
41-44
栏目:
临床研究
出版日期:
2022-01-05

文章信息/Info

Title:
Qidixihuang Guiling decoction on chronic pelvic inflammation and its influence on inflammatory factors and immune function
作者:
张春玲; 马 颖; 孙仲函; 王 宁
(长春市中医院,吉林 长春 130052)
Author(s):
ZHANG Chunling; MA Ying; SUN Zhonghan; WANG Ning
(Changchun City Traditional Chinese Medicine Hospital, Changchun 130052,China)
关键词:
慢性盆腔炎;  芪地膝黄桂苓汤;  中医证候;  炎症状态;  免疫功能
Keywords:
Chronic pelvic inflammatory disease;  Qidixihuang Guiling decoction;  TCM syndrome;  Inflammatory state;  Immune function
分类号:
R 271.1
DOI:
DOI:10.3969/j.issn.1000-7369.2022.01.009
文献标志码:
A
摘要:
目的:观察芪地膝黄桂苓汤对慢性盆腔炎(CPID)的治疗效果及对炎性因子水平和免疫功能的影响。方法:选择CPID患者120例为研究对象,依据随机数字表法分为研究组和对照组,每组各60例,对照组患者以坤复康胶囊治疗,研究组进行芪地膝黄桂苓汤治疗,以临床疗效、中医证候评分和炎性因子水平及免疫因子水平为指标,对治疗效果进行评价。结果:研究组总有效率为91.67%,显著高于对照组的76.67%(P<0.05); 与治疗前相比,两组患者下腹部疼痛、腰骶疼痛、带下异常、月经失调和肛门坠胀五项证候评分均显著降低(P<0.05); 与对照组相比,研究组患者各项指标降低更明显(P<0.05); 与治疗前相比,两组患者IL-1β、IL-18、Caspase-1水平均明显改善(P<0.05); 与对照组相比,研究组IL-1β、IL-18、Caspase-1水平改善更明显(P<0.05); 与治疗前相比,两组患者CD4+、CD8+和CD4+/CD8+水平均明显改善(P<0.05); 与对照组相比,研究组CD4+、CD8+和CD4+/CD8+水平改善更明显(P<0.05)。结论:芪地膝黄桂苓汤对慢性盆腔炎有较好的疗效,能有效减轻患者各项中医证候,改善CPID患者体内炎性状态和免疫功能。
Abstract:
Objective:To investigate the therapeutic effect of Qidixihuang Guiling decoction on CPID and its effect on inflammatory factors and immune factors.Methods:Taking 120 patients who were diagnosed with CPID as the research object.According to the random number table method,it is divided into research group and control group,with 60 cases in each group.The patients in the control group were treated with Kunfukang capsules,and the patients in the research group were treated with Qidixihuang Guiling decoction.The clinical efficacy,syndrome score and inflammatory factor levels,and immune factors were used as indicators to evaluate the therapeutic effect.Results:The total effective rate in the study group was 91.67%,significantly higher than that in the control group was 76.67%(P<0.05).Compared with before treatment,the five syndrome scores of lower abdomen pain,lumbosacral pain,abnormal banding,menstrual disorders and anal bulge were significantly reduced(P<0.05).Compared with before treatment,the levels of IL-1β,IL-18,and Caspase-1 in the two groups were significantly improved(P<0.05),compared with the control group,the levels of IL-1β,IL-18,and Caspase-1 in the study group improved more significantly(P<0.05).Compared with before treatment,the levels of CD4+,CD8+ and CD4+/CD8+ in the two groups were significantly improved(P<0.05),compared with the control group,the levels of CD4+,CD8+ and CD4+/CD8+ in the study group improved more significantly(P<0.05).Conclusion:Qidixihuang Guiling decoction had a good effect on chronic pelvic inflammatory disease,which could effectively relieve the patients' various symptoms and improve the inflammatory state and immune factors in CPID patients.

参考文献/References:

[1] 黄发婷,梁 漫,孙志圣.盆腔灌注联合TDP治疗慢性盆腔炎临床疗效研究[J].陕西医学杂志,2019,48(2):205-207.
[2] 张 展,刘朝晖.盆腔炎性疾病的诊治进展[J].中国实用妇科与产科杂志,2019,35(4):473-477.
[3] 李 娟,马永萍.自拟妇炎宁汤内服加灌肠治疗慢性盆腔炎的疗效及安全性分析[J].辽宁中医杂志,2018,45(5):980-982.
[4] 夏 媛.康妇炎胶囊联合抗生素治疗对慢性盆腔炎患者临床疗效及炎症因子水平影响[J].中华中医药学刊,2017,35(2):241-243.
[5] 张雪丽,刘翠华,厉洪江,等.桂枝茯苓汤联合激素治疗小儿原发性肾病综合征疗效及对患者血清炎性因子的影响[J].陕西中医,2018,39(11):1609-1612.
[6] 田 颖,高晓俐.桂枝茯苓胶囊联合西药治疗多囊卵巢综合征及对内分泌代谢和排卵的影响[J].陕西中医,2017,38(4):444-445.
[7] 曹泽毅.中华妇产科学[M].北京:人民卫生出版社,2014:213-214.
[8] 彭炳格.盆腔炎性疾病诊断与治疗[J].实用妇科内分泌杂志:电子版,2018,5(11):39-40.
[9] 黄 蓓.《证候类中药新药临床研究技术指导原则》发布[J].中医药管理杂志,2018,26(21):107-114.
[10] 国家食品药品监督管理局.中药新药临床研究指南原则:试行[M].北京:中国医药科技出版社,2002:136-138.
[11] 袁 蓉,李坚芬.黄藤素分散片联合左氧氟沙星、替硝唑治疗慢性盆腔炎的临床研究[J].中南医学科学杂志,2018,46(5):501-504.
[12] 李妞妞,王铁延,张丽萍.金刚藤辅助妇科千金片治疗慢性盆腔炎的临床效果[J].宁夏医科大学学报,2018,40(1):65-68.
[13] 李晓霞,徐 旭,马会霞,等.经典名方桂枝茯苓丸的临床和实验研究进展[J].药物评价研究,2018,41(9):166-171.
[14] 史 晨,夏亲华.盆腔炎性疾病后遗症中医药治疗文献分析[J].浙江中医药大学学报,2019,43(5):124-129,134.
[15] 田 燕,广姸鹭.中药临床新用途[M].北京:金盾出版社,2016:14-18.
[16] 施颖意.益气活血止痛汤联合耳穴贴压治疗慢性盆腔炎临床观察[J].新中医,2018,50(12):201-203.
[17] Glennon EKK,Dewi M,Torrevillas BK,et al.Elevated plasma abscisic acid is associated with asymptomatic falciparum malaria and with IgG-/Caspase-1-dependent immunity in plasmodium yoelii-infected mice[J].Sci Rep,2018,8(1):8896.
[18] Bai YL,Sun X,Chu Q,et al.Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β[J].Biosci Rep,2018,38(2):1438.
[19] 孟 芳,陈秀芹,李巧云,等.丹黄祛瘀胶囊联合左氧氟沙星治疗慢性盆腔炎的临床研究[J].现代药物与临床,2019,34(2):199-202.
[20] 张琳琳,周树生,刘 宝.急性肾损伤早期诊断生物标记物的研究进展[J].中国急救复苏与灾害医学杂志,2008,3(12):755-758.

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备注/Memo

备注/Memo:
基金项目:吉林省中医药科技项目(2018140)
更新日期/Last Update: 2022-01-09