[1]王彩霞,韦 林,李春玲,等.补气温阳法治疗老年性胸腰椎骨折中后期便秘临床研究[J].陕西中医,2022,(2):211-214.[doi:DOI:10.3969/j.issn.1000-7369.2022.02.017]
　WANG Caixia,WEI Lin,LI Chunling,et al.Clinical effects of the method of invigorating qi and warming yang in the treatment of senile thoracolumbar fracture with constipation in middle and late stages[J].,2022,(2):211-214.[doi:DOI:10.3969/j.issn.1000-7369.2022.02.017]
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补气温阳法治疗老年性胸腰椎骨折中后期便秘临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年2期
页码:
211-214
栏目:
临床研究
出版日期:
2022-02-05

文章信息/Info

Title:
Clinical effects of the method of invigorating qi and warming yang in the treatment of senile thoracolumbar fracture with constipation in middle and late stages
作者:
王彩霞; 韦 林; 李春玲; 范小春
(南充市中医医院南院区骨科,四川 南充 637000)
Author(s):
WANG Caixia; WEI Lin; LI Chunling; FAN Xiaochun
(Department of Orthopedics,South Campus,Nanchong Hospital of Traditional Chinese Medicine,Nanchong 637000,China)
关键词:
胸腰椎骨折;  便秘;  补气温阳法;  老年;  胃泌素
Keywords:
Thoracolumbar fracture;  Constipation;  Method of invigorating qi and warming yang;  Elderly;  Gastrin
分类号:
R 256.35
DOI:
DOI:10.3969/j.issn.1000-7369.2022.02.017
文献标志码:
A
摘要:
目的:探析补气温阳法在老年性胸腰椎骨折中后期便秘中的治疗效果。方法:选取老年性胸腰椎骨折中后期便秘患者230例,采用随机数字表法将其分为对照组(114例)与治疗组(116例)。对照组予以口服聚乙二醇4000散治疗,治疗组则接受补气温阳法其方药(配方颗粒)治疗,两组均以连续治疗1周为1个疗程,均行2个疗程的治疗。采用Cleveland便秘评分系统(CCS)评价患者治疗前后的便秘严重程度,Bristol大便性状分型法评价大便性状,并对患者的中医证候积分进行统计。评价两组的治疗效果,患者治疗前后胃肠功能以及肠道菌群数量的差异性,评价用药安全性。结果:治疗组治疗有效率为93.10%,明显高于对照组的84.21%(P<0.05)。两组治疗后CCS、Bristol评分以及中医证候积分均较治疗前下降(P<0.05),且治疗组治疗后上述指标评分均低于对照组(P<0.05)。治疗组患者治疗后胃泌素、生长抑素水平均低于对照组,其胃动素水平高于对照组(P<0.05)。治疗后两组乳酸杆菌/双歧杆菌数量高于治疗前,球杆菌、肠杆菌数量低于治疗前(P<0.05),且治疗组变化程度大于对照组(P<0.05)。两组患者面红、皮疹及恶心呕吐等不良反应发生率分别为8.62%和6.14%,两组比较,差异无统计学意义(P>0.05)。结论:补气温阳法在老年性胸腰椎骨折中后期便秘中的治疗效果显著,其能够明显改善患者的便秘症状和胃肠道功能,纠正肠道菌群失调。
Abstract:
Objective:To explore the therapeutic effect of method of invigorating qi and warming yang on senile thoracolumbar fracture with constipation in middle and late stages.Methods:230 elderly patients with thoracolumbar fracture and constipation in middle and late stages were selected.Using random number table method,the patients were divided into control group(114 cases)and treatment group(116 cases).The control group was treated by oral administration of polyethylene glycol 4000 powder,and the treatment group was treated by method of invigorating qi and warming yang.1 week was a course of treatment,and both groups received 2 courses of treatment.The CCS was used to evaluate the severity of constipation before and after treatment,and the Bristol stool form scale was used to evaluate stool traits.The patients' TCM syndrome scores were counted.Gastrointestinal function and the number of intestinal flora were compared before and after treatment.Results:The effective rate of treatment in the treatment group was 93.10%,significantly higher than 84.21% in the control group(P<0.05).After treatment,the CCS scores,Bristol scores and TCM syndrome scores of the two groups were reduced(P<0.05),and the above scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the levels of gastrin and somatostatin in the treatment group were lower than those in the control group,and the motilin level was higher than that in the control group(P<0.05).After treatment,the quantity of lactobacillus/bifidobacterium was increased,and the quantities of coccobacillus and enterobacterium were reduced in the two groups(P<0.05).Changes of the numbers in the treatment group were greater than those in in the control group(P<0.05).The incidence of adverse reactions such as flushing,skin rash,nausea and vomiting in the two groups during treatment were 8.62% and 6.14% respectively(P>0.05).Conclusion:The method of invigorating qi and warming yang is markedly effective in the treatment of senile thoracolumbar fracture with constipation in middle and late stages.It can significantly improve constipation symptoms and gastrointestinal function,and correct alteration of intestinal flora.

参考文献/References:

[1] Seyedian SS,Sharifi L,Manouchehri N,et al.A comparative study of transcutaneous interferential electrical stimulation plus behavioral therapy and behavioral therapy alone on constipation in postoperative Hirschsprung disease children[J].J Pediatr Surg,2017,52(1):177-183.
[2] 黄丽君,熊润萍,王璐瑶,等.五位一体合作模式在老年股骨粗隆间骨折患者便秘预防中的应用[J].齐鲁护理杂志,2019,25(24):33-35.
[3] 曾樊莉,匡 静.老年骨折便秘患者采用中医特色护理干预临床疗效观察[J].湖北中医药大学学报,2019,21(2):102-104.
[4] 李 敏,周惠芬,丁曙晴.慢性功能性便秘中医体质特点分析[J].陕西中医,2017,38(2):149-151.
[5] 王李瑶,孙 龙,毛加荣,等.Cajal间质细胞在出口梗阻性便秘直肠肌壁中的表达相关研究[J].陕西医学杂志,2020,49(3):31-34.
[6] 丰胜利.中医治疗老年难治性便秘的现状与思考[J].中医杂志,2020,61(10):905-908.
[7] Drossman DA.The functional gastrointestinal disorders and the Rome Ⅲ process[J].Gastroenterology,2006,130(5):1377-1390.
[8] 詹红生,何 伟.中医骨伤科学[M].北京:人民卫生出版社,2019:128-133.
[9] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:11.
[10] Agachan F,Chen T,Pfeifer J,et al.A constipation scoring system to simplify evaluation and management of constipated patients[J].Dis Colon Rectum,1996,39(6):681-685.
[11] Lewis SJ,Heaton KW.Stool form scale as a useful guide to intestinal transit time[J].Scand J Gastroenterol,1997,32(9):920-924.
[12] 中华人民共和国卫生部.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,1997:54-57.
[13] 薛雅瑜.四磨汤治疗骨折患者及对胃肠功能与免疫功能的影响[J].陕西中医,2015,36(4):443-446.
[14] 郑宏明,石志敏.电针配合耳穴贴压治疗胸腰椎压缩性骨折术后便秘的随机对照研究[J].针灸临床杂志,2016,32(9):17-20.
[15] 徐 欢.腹部穴位按摩联合耳穴贴压治疗老年功能性便秘40例[J].中国中医药科技,2020,27(6):996-998.
[16] 程 莹.小麦纤维素联合布拉氏酵母菌散剂治疗小儿功能性便秘疗效及对患儿血清指标影响分析[J].陕西医学杂志,2018,47(10):1328-1330.
[17] 姚辛敏,周晓洁,周妍妍.肉苁蓉化学成分及药理作用研究进展[J].中医药学报,2021,49(2):93-97.
[18] 杨雅蛟,孔维军,孙 兰,等.槟榔化学成分和药理作用及临床应用研究进展[J].世界科学技术-中医药现代化,2019,21(12):2583-2591.
[19] 毛 刚,赵景文.补中益气汤加减配合穴位贴敷治疗出口梗阻型便秘的疗效观察[J].中国中西医结合外科杂志,2020,26(1):83-88.
[20] Giacomin P,Agha Z,Loukas A.Helminths and intestinal flora team up to improve gut health[J].Trends Parasitol,2016,32(9):664-666.
[21] 袁榴翼,李小锦,尹清晟,等.中药干预肠道菌群改善肠黏膜屏障功能的研究进展[J].中草药,2018,49(8):1932-1938.

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备注/Memo

备注/Memo:
基金项目:四川省中医药管理局科研项目(2021MS374); 四川省南充市科技计划项目(19YFZJ0004,21YFZJ0062)
更新日期/Last Update: 2022-02-09