[1]巴燕·艾克海提,古洁乃特汗·拜克里木.加味四妙勇安汤联合艾灸治疗类风湿性关节炎疗效研究[J].陕西中医,2022,(3):314-317.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.010]
　Bayan·Ke'erhaiti,Gujienaitehan·Baikelimu.Study on curative effect of modified Simiao Yongan decoction combined with moxibustion on rheumatoid arthritis[J].,2022,(3):314-317.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.010]
点击复制

加味四妙勇安汤联合艾灸治疗类风湿性关节炎疗效研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年3期
页码:
314-317
栏目:
临床研究
出版日期:
2022-03-05

文章信息/Info

Title:
Study on curative effect of modified Simiao Yongan decoction combined with moxibustion on rheumatoid arthritis
作者:
巴燕·艾克海提; 古洁乃特汗·拜克里木
(新疆维吾尔自治区中医医院,新疆 乌鲁木齐 830099)
Author(s):
Bayan·Ke'erhaiti; Gujienaitehan·Baikelimu
(Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine,Urumqi 830099,China)
关键词:
类风湿性关节炎;  加味四妙勇安汤;  艾灸;  红细胞沉降率;  类风湿因子;  血小板
Keywords:
Rheumatoid arthritis;  Modified Simiao Yongan decoction;  Moxibustion;  Erythrocyte sedimentation rate;  Rheumatoid factor;  Platelet
分类号:
R 593.22
DOI:
DOI:10.3969/j.issn.1000-7369.2022.03.010
文献标志码:
A
摘要:
目的:探讨加味四妙勇安汤联合艾灸治疗类风湿性关节炎(RA)的疗效及对患者病情活动指标的影响。方法:选取100例湿热痹阻型RA患者,采用简单随机分组法将患者分为观察组和对照组,每组各50例。对照组采用艾灸治疗,观察组在对照组基础上联合加味四妙勇安汤治疗。评估两组临床疗效和治疗期间的不良反应发生情况。分别于治疗前后检测患者中医证候积分、压痛关节数(TJC)、肿胀关节数(SJC)、晨僵时间、DAS28评分、VAS评分、红细胞沉降率(ESR)、血小板计数(PLT)、C-反应蛋白(CRP)、类风湿因子(RF)水平。结果:观察组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者中医证候积分、SJC和TJC数量、晨僵时间、DAS28评分、VAS评分、ESR、CRP、PLT、RF水平均低于对照组,差异有统计学意义(均P<0.05)。治疗期间,两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:加味四妙勇安汤联合艾灸治疗RA临床疗效较好,可缓解关节肿痛,缩短晨僵时间,减轻炎症反应,安全性较好。
Abstract:
Objective:To investigate the curative effect of modified Simiao Yongan decoction combined with moxibustion on rheumatoid arthritis(RA)and its influences on disease activity indexes.Methods:100 patients with RA of Shire Bizu type were divided into observation group and control group according to simple random grouping method,50 cases in each group.The control group was treated with moxibustion,while the observation group was additionally treated with modified Simiao Yongan decoction.The clinical curative effect and occurrence of adverse reactions during treatment in both groups were evaluated.The levels of Chinese medicine syndrome score,tender joint count(TJC),swollen joint count(SJC),morning stiffness time,DAS28 score,VAS score,erythrocyte sedimentation rate(ESR),platelet(PLT),C-reactive protein(CRP),rheumatoid factor(RF)were determined before and after treatment.Results:The response rate of treatment in the observation group was significantly higher than that in the control group,difference statistically significant(P<0.05).After treatment,scores of TCM syndromes,SJC,TJC,morning stiffness time,DAS28 and VAS scores,and levels of ESR,CRP,PLT and RF in the observation group were significantly lower than those in the control group,difference statistically significant(all P<0.05).The incidence of adverse reactions during treatment between the two groups was not statistically significant(P>0.05).Conclusion:Modified Simiao yongan decoction combined with moxibustion has good clinical efficacy in the treatment of RA,which can relieve joint swelling and pain,shorten the time of morning stiffness,relieve inflammatory reaction,with better safety.

参考文献/References:

[1] Firestein GS,McInnes IB.Immunopathogenesis of rheumatoid arthritis[J].Immunity,2017,46(2):183-196.
[2] 叶天士.临证指南医案[M].北京:北京科学技术出版社,2014:294.
[3] 朱竹菁,苏 励,田 雨.蠲痹化湿汤治疗女性寒湿型类风湿关节炎临床研究[J].陕西中医,2020,41(5):632-635.
[4] Jekic B,Maksimovic N,Damnjanovic T.Methotrexate pharmacogenetics in the treatment of rheumatoid arthritis[J].Pharmacogenomics,2019,20(17):1235-1245.
[5] 朱田田,赵中亭,赵怡坤,等.艾灸对类风湿关节炎炎性损伤修复机制的现代研究进展[J].针刺研究,2017,42(3):271-274.
[6] 李光辉,张军平,丁 义,等.四妙勇安汤抑制血管内皮细胞P-选择素、NF-κB表达的实验研究[J].中华中医药学刊,2017,35(8):2058-2060.
[7] 国家食品药品监督管理总局.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:115-119.
[8] 中华医学会风湿病学分会.类风湿关节炎诊治指南(草案)[J].中华风湿病学杂志,2003,17(4):250-254.
[9] 傅丽晖,张 瑾,梁 良.MRI动态增强技术对活动性类风湿性关节炎疗效判断的应用价值[J].医学影像学杂志,2019,29(5):828-832.
[10] 鲍嘉敏,宋永嘉,陈锦漫,等.自我管理对类风湿性关节炎患者疼痛缓解的效果评价:Meta分析和系统评价[J].世界中医药,2020,15(7):89-96.
[11] McWilliams DF,Walsh DA.Pain mechanisms in rheumatoid arthritis[J].Clin Exp Rheumatol,2017,35(5):94-101.
[12] McGonagle D,Watad A,Savic S.Mechanistic immunological based classification of rheumatoid arthritis[J].Autoimmun Rev,2018,17(11):1115-1123.
[13] 卢文艺,周祖山,周艳华,等.周祖山教授分期辨治类风湿关节炎经验探析[J].中医药信息,2019,36(1):62-65.
[14] Aletaha D,Smolen JS.Diagnosis and management of rheumatoid arthritis:A review[J].JAMA,2018,320(13):1360-1372.
[15] Uneda A,Hirashita K,Kanda T,et al.Primary central nervous system methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis:Case report and review of literature[J].NMC Case Rep Journal,2020,7(3):121-127.
[16] 王瑞萍.类风湿关节炎患者血清中抗CCP抗体和TNF-α表达的临床意义[J].重庆医学,2017,12(46):46-47,50.
[17] 徐士荣,徐 骏,徐红珍,等.RF抗CCP抗体,抗AKA及CRP联合检测在类风湿关节炎诊断中的应用价值[J].检验医学与临床,2020,17(2):61-63.
[18] 高学祥,汪六庆.血清抗CCP抗体、RF、CRP、ESR水平联合检测在类风湿性关节炎患者早期诊断中的应用价值[J].检验医学与临床,2018,15(14):2156-2159.
[19] 孙 莉,王晓非.血常规指标判断类风湿关节炎活动性意义的研究进展[J].山东医药,2019,59(2):110-112.
[20] 刘昌莲,贺冬冬,李晓明,等.艾拉莫德治疗类风湿关节炎疗效及对患者免疫炎症因子水平和骨代谢指标的影响[J].陕西医学杂志,2020,49(5):603-607.
[21] 申 丹,杨卫彬,王晓曼.血小板与类风湿关节炎中医证候相关性初探[J].世界中医药,2016,11(8):1640-1643.

相似文献/References:

[1]程红卫,秦 艳,胡筱娟.青白通痹胶囊的组方学研究*[J].陕西中医,2019,(4):537.
[2]全 健,丁文涛 Δ,武 辉.穴位注射配合桂枝芍药知母汤加减治疗类风湿性关节炎临床研究[J].陕西中医,2019,(5):671.
　QUAN Jian,DING Wentao,WU Hui..Rheumatoid arthritis treated by acupoint injection combined with Guizhi Shaoyao Zhimu decoction[J].,2019,(3):671.
[3]戴凤翔,邱联群△.当归四逆汤联合灸法治疗类风湿性关节炎临床研究[J].陕西中医,2019,(9):1235.
[4]刘 茜,张翊一,李映雪△,等.川羌除痹汤联合西药对类风湿性关节炎患者免疫功能及Th1/Th2型细胞因子的影响[J].陕西中医,2019,(12):1732.
　LIU Qian,ZHANG Yiyi,LI Yingxue,et al.Effects of Chuanqiang Chubi decoction and western medicine on immune function and Th1/Th2 cytokines in patients with rheumatoid arthritis[J].,2019,(3):1732.
[5]张 娜,唐华燕.生地苦参汤联合艾拉莫德对类风湿性关节炎患者血清抗CCP抗体及炎症因子的影响[J].陕西中医,2022,(3):318.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.011]
　ZHANG Na,TANG Huayan.Effect of Shengdi Kushen decoction combined with iguratimod on serum anti CCP antibody and inflammatory factors in rheumatoid arthritis[J].,2022,(3):318.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.011]
[6]吕建敏,刘广宇,赵海河,等.温针灸配合独活寄生汤治疗类风湿性关节炎临床研究[J].陕西中医,2022,(11):1613.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.029]
　LYU Jianmin,LIU Guangyu,ZHAO Haihe,et al.Therapeutic effect of warm acupuncture combined with Duhuo Jisheng decoction on patients with rheumatoid arthritis[J].,2022,(3):1613.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.029]
[7]邓文雯,肖 智,姜 如.透骨血竭散对类风湿性关节炎模型大鼠炎症因子的影响[J].陕西中医,2023,(7):868.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.009]
　DENG Wenwen,XIAO Zhi,JIANG Ru.Effect of Tougu Xuejie powder on inflammatory factors in rats with rheumatoid arthritis[J].,2023,(3):868.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.009]
[8]代雨晴,熊 浪,唐 芳,等.中医药调控中性粒细胞治疗类风湿性关节炎研究进展[J].陕西中医,2024,(11):1576.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.030]
　DAI Yuqing,XIONG Lang,TANG Fang,et al.Research progress of Chinese medicine regulation of neutrophils in treatment of rheumatoid arthritis[J].,2024,(3):1576.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.030]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助地区项目(81860834); 新疆维吾尔自治区中医医院院内课题(ZYY2013PY13)
更新日期/Last Update: 2022-03-09