[1]张 娜,唐华燕.生地苦参汤联合艾拉莫德对类风湿性关节炎患者血清抗CCP抗体及炎症因子的影响[J].陕西中医,2022,(3):318-320,341.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.011]
　ZHANG Na,TANG Huayan.Effect of Shengdi Kushen decoction combined with iguratimod on serum anti CCP antibody and inflammatory factors in rheumatoid arthritis[J].,2022,(3):318-320,341.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.011]
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生地苦参汤联合艾拉莫德对类风湿性关节炎患者血清抗CCP抗体及炎症因子的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年3期
页码:
318-320,341
栏目:
临床研究
出版日期:
2022-03-05

文章信息/Info

Title:
Effect of Shengdi Kushen decoction combined with iguratimod on serum anti CCP antibody and inflammatory factors in rheumatoid arthritis
作者:
张 娜; 唐华燕
(上海中医药大学附属市中医医院风湿病科,上海 200071)
Author(s):
ZHANG Na; TANG Huayan
(Department of Rheumatology,Shanghai Hospital of Traditional Chinese Medicine,Shanghai University of Chinese Medicine,Shanghai 200071,China)
关键词:
类风湿性关节炎;  生地苦参汤;  艾拉莫德;  抗环瓜氨酸肽抗体;  炎症因子;  免疫平衡
Keywords:
Rheumatoid arthritis;  Shengdi Kushen decoction;  Iguratimod;  Anti-cyclic citrullinated peptide antibody;  Inflammatory factor;  Immune balance
分类号:
R 593.22
DOI:
DOI:10.3969/j.issn.1000-7369.2022.03.011
文献标志码:
A
摘要:
目的:观察生地苦参汤联合艾拉莫德对类风湿性关节炎患者临床疗效、血清抗环瓜氨酸肽(CCP)抗体及炎症因子的影响。方法:将80例类风湿性关节炎患者随机分为对照组和观察组,每组40例,疗程3个月。观察两组治疗前后血清CCP抗体、干扰素-γ(IFN-γ)、白介素-4(IL-4)、肿瘤坏死因子α(TNF-α)、干扰素α(IFN-α)水平及临床总有效率。结果:观察组血清CCP、IFN-γ、IFN-α、TNF-α水平均低于对照组,IL-4水平高于对照组,差异有统计学意义(均P<0.05)。观察组显效率、有效率高于对照组,差异有统计学意义(均P<0.05)。观察组总不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:生地苦参汤治疗类风湿性关节炎患者可降低血清CCP抗体水平,抑制TLR通路细胞因子TNF-α、IFN-α分泌,从而调节IFN-γ、IL-4平衡,发挥稳定免疫微环境作用。
Abstract:
Objective:To observe the effects of Shengdi Kushen decoction combined with iguratimod on the clinical efficacy,serum anti-cyclic citrullinated peptide antibodies and inflammatory factors in patients with rheumatoid arthritis.Methods:80 patients with rheumatoid arthritis were randomly divided into control group and observation group,with 40 cases in each group,and course of treatment 3 months.The levels of serum CCP,IFN-γ,IL-4,TNF-α,IFN-α and the total clinical effective rate were observed before and after treatment between the two groups.Results:The levels of CCP,IFN-γ,IFN-α and TNF-α in the observation group were lower than those in the control group,while the level of IL-4 was higher than that in the control group,difference statistically significant(all P<0.05).The significant efficiency and effective rate in the observation group were higher than those in the control group,differences statistically significant(all P<0.05).The incidence of total adverse reactions in the observation group was lower than that in the control group,difference statistically significant(P<0.05).Conclusion:Shengdi Kushen decoction can reduce serum anti-cyclocitline peptide antibody level and inhibit the secretion of TNF-α and IFN-α in TLR pathway,thus regulating the balance of IFN-γ and IL-4 to stabilize the immune microenvironment.

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备注/Memo

备注/Memo:
基金项目:国家重点研发计划项目中医药现代化研究专项(2018YFC1705502); 上海市卫生和计划生育委员会中医药科研课题(2018LP031); 上海市卫生和计划生育委员会名老中医学术经验研究工作室建设项目(ZYSNXD-CC-MZY048)
更新日期/Last Update: 2022-03-09