[1]李 芮,刘 健,靳 楠,等.基于网络药理学探讨当归补血汤治疗再生障碍性贫血作用机制[J].陕西中医,2022,(3):384-389.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.028]
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基于网络药理学探讨当归补血汤治疗再生障碍性贫血作用机制

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年3期
页码:
384-389
栏目:
方药纵横
出版日期:
2022-03-05

文章信息/Info

作者:
李 芮12刘 健12靳 楠12蒋佩珍12毛 月12唐旭东2
(1.北京中医药大学,北京 100029; 2.中国中医科学院西苑医院血液科,北京 100091)
关键词:
再生障碍性贫血 当归补血汤 黄芪 当归 网络药理学 有效成分
分类号:
R 556
DOI:
DOI:10.3969/j.issn.1000-7369.2022.03.028
文献标志码:
A
摘要:
目的:基于网络药理学探讨当归补血汤治疗再生障碍性贫血作用机制。方法:采用中药系统药理学数据库和分析平台筛选出黄芪与当归的潜在活性成分,利用Uniprot平台预测其活性成分的潜在靶点。利用OMIM、DisGeNET、DrugBank、Genecards数据库,预测和筛选其治疗再生障碍性贫血的作用靶点,运用韦恩图对药物靶点和疾病靶点进行映射。通过String数据库和Cytoscape 3.8.0软件对主要靶点构建蛋白质相互作用网络,以获得当归补血汤治疗再生障碍性贫血的关键靶点,通过R语言对关键靶点进行GO和KEGG富集分析。结果:筛选到当归补血汤有效成分20个,药物靶点221个,再生障碍性贫血疾病靶点781个,最终获得关键靶点54个,KEGG通路121条。结论:当归补血汤中槲皮素、芒柄花黄素、当归多糖、山柰酚、β-谷甾醇、豆甾醇等多种成分可能作用于TP53、IL6、VEGFA、AKT1、TNF、CASP3等靶点,通过调控HIF-1、JAK-STAT、TNF等通路发挥治疗再生障碍性贫血作用。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(81673819,82074258); 国家中医药管理局中医药行业科研专项(201507001-13)
更新日期/Last Update: 2022-03-09