[1]齐 宁,宋姝西,刘香玉,等.参芪延肾方治疗慢性肾脏病疗效及对患者半乳糖缺陷IgA1、晚期糖基化终产物和微炎性反应状态的影响[J].陕西中医,2022,(5):596-599.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.012]
　QI Ning,SONG Shuxi,LIU Xiangyu,et al.Effects of Shenqi Yanshen recipe on the levels of Gd-IgA1,AGEs and micro inflammatory response in patients with chronic kidney disease[J].,2022,(5):596-599.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.012]
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参芪延肾方治疗慢性肾脏病疗效及对患者半乳糖缺陷IgA1、晚期糖基化终产物和微炎性反应状态的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年5期
页码:
596-599
栏目:
临床研究
出版日期:
2022-05-05

文章信息/Info

Title:
Effects of Shenqi Yanshen recipe on the levels of Gd-IgA1,AGEs and micro inflammatory response in patients with chronic kidney disease
作者:
齐 宁1; 宋姝西2 ; 刘香玉1; 杨宏伟2; 王志文1; 刘宝义2
(1.华北理工大学附属医院,河北 唐山 063000; 2.唐山市人民医院,河北 唐山 063000)
Author(s):
QI Ning; SONG Shuxi; LIU Xiangyu; YANG Hongwei; WANG Zhiwen; LIU Baoyi
(Affiliated Hospital of North China University of Technology,Tangshan 063000,China)
关键词:
慢性肾脏病;  参芪延肾方;  晚期糖基化终产物;  炎症反应;  肾功能
Keywords:
Chronic kidney disease;  Shenqi Yanshen recipe;  AGEs;  Inflammatory reaction;  Renal function
分类号:
R 692
DOI:
DOI:10.3969/j.issn.1000-7369.2022.05.012
文献标志码:
A
摘要:
目的:探讨参芪延肾方对慢性肾脏病患者半乳糖缺陷IgA1(Gd-IgA1)、晚期糖基化终产物(AGEs)水平及微炎性反应状态的影响。方法:选择慢性肾脏病患者96例,随机分为对照组和研究组各48例。其中两组患者均给予常规治疗,对照组给予醋酸泼尼松片治疗,观察组在此基础上给予参芪延肾方治疗,比较两组患者治疗前后血液流变学指标、肾功能指标以及血清Gd-IgA1、AGEs水平、炎症水平变化,观察两组患者临床治疗效果差异。结果:治疗8周后,两组全血低切、全血高切、血浆黏度值均明显降低,研究组更明显(P<0.05)。用药8周后,两组尿微量白蛋白(UmAlb)、24 h 尿微量白蛋白排泄率(UAER)、血肌酐(Scr)水平降低,研究组更明显(P<0.05)。治疗8周后,两组血清Gd-IgA1、AGEs、C-反应蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8)水平下降,研究组低于对照组(P<0.05)。研究组总有效率明显高于对照组(P<0.05)。结论:参芪延肾方可改善慢性肾脏病患者肾功能,降低Gd-IgA1、AGEs水平,减轻微炎性反应状态。
Abstract:
Objective:To investigate the effects of Shenqi Yanshen recipe on the levels of galactose deficient IgA1(Gd-IgA1),advanced glycation end products(AGEs)and micro inflammatory response in patients with chronic kidney disease.Methods:A total of 96 patients with chronic kidney disease were randomly divided into control group(n=48)and study group(n=48).The two groups were given routine treatment,the control group was treated with prednisone acetate tablets,and the observation group was treated with Shenqi Yanshen recipe on the basis of the control group.The changes of hemorheological indexes,renal function indexes,serum Gd-IgA1,AGEs levels and inflammation levels before and after treatment were compared between the two groups,and the differences of clinical treatment effects between the two groups were observed.Results:After 8 weeks of treatment,the values of LS,HS and PV decreased significantly in the two groups,especially in the study group(P<0.05).After 8 weeks of treatment,the levels of Umalb,UAER and Scr decreased in the two groups,especially in the study group(P<0.05).After 8 weeks of treatment,the levels of serum Gd-IgA1,AGEs,CRP,IL-6 and IL-8 in the study group were lower than those in the control group(P<0.05).The total effective rate of the study group was significantly higher than that of the control group(P<0.05).Conclusion:Shenqi Yanshen recipe can improve renal function,reduce the levels of Gd-IgA1 and AGEs,and reduce the state of micro inflammatory reaction in patients with chronic nephritis.It has satisfactory clinical effect and is worthy of popularization and application.

参考文献/References:

[1] 张宏强,李桂霞,章彩凤,等.许筠治疗慢性肾脏病临床药对举隅[J].陕西中医,2020,41(1):111-113.
[2] 马雷雷,王明哲,刘玉宁,等.肾炎防衰液延缓慢性肾脏病5期非透析患者透析时机的探索研究[J].中华中医药杂志,2020,35(4):2120-2123.
[3] 张显龙,刘旭生,傅立哲,等.远程饮食记录法与纸质3 d饮食记录法对慢性肾脏病患者营养管理依从性的影响研究[J].中国全科医学,2021,24(15):1909-1914.
[4] 陈玉贞,徐家云.来氟米特联合中小剂量糖皮质激素治疗慢性进展性IgA肾脏病的疗效及安全性分析[J].中华肾脏病研究电子杂志,2019,8(5):208-212.
[5] 刘开翔,龚 蓉,冯 杰.单纯糖皮质激素治疗IgA肾病的系统评价[J].中国中西医结合肾病杂志,2020,21(4):321-327.
[6] 马春成,李叶枚,申 旺,等.加味六味地黄汤联合尿激酶治疗早中期慢性肾功能衰竭疗效研究[J].陕西中医,2019,40(3):375-377.
[7] 程勇前,蔡广研.2018年全球改善肾脏病预后委员会慢性肾脏病中丙型肝炎预防、诊断、评价和治疗指南更新概要及其解读[J].中华传染病杂志,2019,37(1):44-50.
[8] 卞志翔,陈佩华,顾慧益,等.非布司他片联合贝前列素钠片对高尿酸血症合并慢性肾脏病患者疗效观察[J].重庆医学,2019,48(14):2484-2486.
[9] 杨 雄,高 伟,邱万胜,等.白蛋白球蛋白比值对慢性肾脏病患者预后判断的价值研究[J].陕西医学杂志,2020,49(1):4-7.
[10] Neaga B,Bba C,Knc D,et al.Exome sequencing and metabolomic analysis of a chronic kidney disease and hearing loss patient family revealed RMND1 mutation induced sphingolipid metabolism defects-science direct[J].Saudi Journal of Biological Sciences,2020,27(1):324-334.
[11] 王世琤,杜 华,张 宁.基于复杂网络技术和点式互信息分析慢性肾脏病本虚标实证中药配伍规律[J].北京中医药,2020,39(6):548-552.
[12] 孙蓓蓓,王云满,毕月萍,等.中医辨证治疗206例慢性肾脏病1～2期多中心前瞻性临床研究[J].中华中医药杂志,2019,34(11):5479-5483.
[13] 赵爱萍,吴洋洋,吴 竞,等.温阳活血法联合常规治疗对阳虚血瘀型3～4期慢性肾脏病患者的临床疗效[J].中成药,2019,41(1):70-74.
[14] 王 岚,王 平,邹新蓉,等.从“肾藏精主骨”理论探讨中医药治疗CKD骨-血管轴病变的机理[J].时珍国医国药,2020,31(2):385-387.
[15] 刘 毓,刘 鹏,韩晶雪,等.基于网络药理学大黄治疗慢性肾脏病机制研究[J].中华中医药学刊,2021,39(2):32-36.
[16] 黄一珊,张帅星,刘伟敬,等.黄芪在肾脏病中的应用及不良反应[J].中国中西医结合肾脏病杂志,2020,21(6):550-552.
[17] 徐闪闪,王 龙,张 霞,等.清热止血方联合雷公藤多苷治疗儿童紫癜性肾炎临床疗效及对Gd-IgA1影响的研究[J].时珍国医国药,2020,31(4):883-886.
[18] 宋轻雷,刘 颖,刘乃全,等.血清异常糖基化IgA1在40例IgA肾脏病诊断中的应用价值研究[J].中国实用内科杂志,2019,39(3):270-273.
[19] 肖 勇,贺海东,胡 屏,等.血清Gd-IgA1水平与IgA肾脏病患者临床及病理特点的关系分析[J].临床输血与检验,2021,23(4):492-496.
[20] 杨 莹,蔡广研.晚期糖基化终产物促进慢性肾脏病进展的作用及防治策略[J].解放军医学杂志,2020,45(5):554-558.

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备注/Memo

备注/Memo:
基金项目:河北省中医药管理局科研计划项目(2020218)
更新日期/Last Update: 2022-05-09