[1]李吉旭,张 林,李 财,等.半夏白术天麻汤治疗H型高血压Meta分析[J].陕西中医,2022,(8):1122-1127.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.033]
　LI Jixu,ZHANG Lin,LI Cai,et al.Meta-analysis of Banxia Baizhu Tianma decoction in treating H-type hypertension[J].,2022,(8):1122-1127.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.033]
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半夏白术天麻汤治疗H型高血压Meta分析
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年8期
页码:
1122-1127
栏目:
Meta分析
出版日期:
2022-08-05

文章信息/Info

Title:
Meta-analysis of Banxia Baizhu Tianma decoction in treating H-type hypertension
作者:
李吉旭1; 张 林2; 李 财3; 秦后伟2
(1.山东中医药大学第一临床医学院,山东 济南 250355; 2.泰安市中医医院,山东 泰安 271099; 3.山东中医药大学针灸推拿学院,山东 济南 250355)
Author(s):
LI Jixu; ZHANG Lin; LI Cai; QIN Houwei
(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
关键词:
H型高血压;  半夏白术天麻汤;  血同型半胱氨酸;  收缩压;  舒张压
Keywords:
H-type hypertension;  Banxia Baizhu Tianma decoction;  Homocysteine;  Systolic blood pressure;  Diastolic blood pressure
分类号:
R 544.1
DOI:
DOI:10.3969/j.issn.1000-7369.2022.08.033
文献标志码:
A
摘要:
目的:系统评价半夏白术天麻汤治疗H型高血压的有效性与安全性。方法:检索中国知网、万方、维普、中国生物医学文献服务系统、Embase、Cochrane Library、Pub Med数据库中半夏白术天麻汤治疗H型高血压的随机对照试验,时间为建库起至2021年11月14日,用Revman 5.4.1软件进行Meta分析,对异质性采用敏感性分析,发表偏倚采用漏斗图评价。结果:共纳入19项随机对照试验,共1449例患者,Meta分析显示:与对照组相比,观察组患者的收缩压明显更低[MD=-10.37,95%CI(-12.62,-8.11),P<0.00001]、舒张压明显更低[MD=-8.72,95%CI(-10.05,-7.38),P<0.00001)]、血同型半胱氨酸水平明显更低[MD=-3.91,95%CI(-4.67,-3.16),P<0.00001],两组患者不良反应比较,差异无统计学意义。结论:半夏白术天麻汤可明显改善H型高血压患者的血压和血同型半胱氨酸水平,且安全性较好。
Abstract:
Objective:To systematically evaluate the efficacy and safety of Banxia Baizhu Tianma decoction in treating H-type hypertension.Methods:We searched the randomized controlled trials of Banxia Baizhu Tianma decoction in the treatment of H-type hypertension from CNKI,Wanfang,VIP,Sino Med,Cochrane Library,Embase and Pub Med databases,the search period was from database establishment to November 14,2021.Literature quality was evaluated using the 5.4.1 risk assessment tool recommended by the Cochrane Handbook,Meta-analysis was performed with Revman 5.4.1 software,sensitivity analysis was used for heterogeneity,and funnel plot was used for publication bias evaluation.Results:19 RCTs included,1449 total patients.Meta-analysis showed that compared with the control group,the systolic blood pressure[MD=-10.37,95%CI(-12.62,-8.11),P<0.00001],diastolic blood pressure [MD=-8.72,95%CI(-10.05,-7.38),P<0.00001] and blood homocysteine level in the observation group were significantly lower [MD=-3.91,95%CI(-4.67,-3.16),P<0.00001].There was no significant difference in adverse reactions between the two groups.Conclusion:Banxia Baizhu Tianma decoction can obviously improve the blood pressure and blood homobuchine level in patients with H-type hypertension.Limited by the quality and quantity of included literatures,the above conclusions need to be confirmed by high-level evidence-based medical evidence.

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备注/Memo

备注/Memo:
基金项目:山东省中医药科技青年项目(2020Q104)
更新日期/Last Update: 2022-08-10