[1]马国辉,董艳玲,吴 楠,等.养阴解毒汤对气阴两虚型晚期鼻咽癌放化疗患者免疫功能和癌因性疲乏的影响[J].陕西中医,2022,(10):1407-1410.[doi:DOI:10.3969/j.issn.1000-7369.2022.10.020]
　MA Guohui,DONG Yanling,WU Nan,et al.Effect of Yangyin Jiedu decoction combined with radiotherapy and chemotherapy on immune function and cancer-related fatigue of advanced nasopharyngeal carcinoma cases with syndrome of qi and yin deficiency[J].,2022,(10):1407-1410.[doi:DOI:10.3969/j.issn.1000-7369.2022.10.020]
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养阴解毒汤对气阴两虚型晚期鼻咽癌放化疗患者免疫功能和癌因性疲乏的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年10期
页码:
1407-1410
栏目:
临床研究
出版日期:
2022-10-05

文章信息/Info

Title:
Effect of Yangyin Jiedu decoction combined with radiotherapy and chemotherapy on immune function and cancer-related fatigue of advanced nasopharyngeal carcinoma cases with syndrome of qi and yin deficiency
作者:
马国辉1; 董艳玲1; 吴 楠2; 李 倩1; 郑 加1
(1.廊坊市第四人民医院,河北 廊坊 065799; 2.霸州市中医院口腔科,河北 霸州 065700)
Author(s):
MA Guohui; DONG Yanling; WU Nan; LI Qian; ZHENG Jia
(The Fourth People's Hospital of Langfang,Langfang 065799,China)
关键词:
癌因性疲乏;  鼻咽癌;  养阴解毒汤;  气阴两虚证;  免疫功能;  不良反应
Keywords:
Cancer-related fatigue;  Nasopharyngeal carcinoma;  Yangyin Jiedu decoction;  Syndrome of qi and yin deficiency;  Immune function;  Adverse reaction
分类号:
R 739.6
DOI:
DOI:10.3969/j.issn.1000-7369.2022.10.020
文献标志码:
A
摘要:
目的:观察养阴解毒汤对气阴两虚型晚期鼻咽癌放化疗患者的疗效以及免疫功能和癌因性疲乏的影响。方法:将94例晚期鼻咽癌患者随机分为观察组和对照组,每组47例。对照组患者予放化疗治疗; 观察组患者在对照组基础上口服养阴解毒汤。两组连续治疗9周,并随访6个月。比较两组疗效、不良反应、外周血淋巴细胞亚群、癌因性疲乏评分。结果:观察组患者总有效率为87.23%,与对照组65.96%比较,差异有统计学意义(P<0.05); 观察组治疗期间白细胞减少、中性粒细胞减少、血红蛋白减少、胃肠道反应、口腔黏膜炎、放射性皮炎的发生率与对照组比较均下调,并且两组口腔黏膜炎发生率比较差异有统计学意义(P<0.05); 观察组患者治疗后的CD3+、CD4+高于对照组CD8+低于对照组(P<0.05)。随访6个月后,观察组患者CD3+、CD4+、CD8+较对照组均明显改善(P<0.05)。治疗后,对照组患者躯体疲乏、情感疲乏、认知疲乏评分明显增加,且观察组以上评分明显低于对照组(P<0.05)。结论:对气阴两虚型晚期鼻咽癌放化疗患者予养阴解毒汤干预疗效显著,可有效减轻放化疗所引起的不良反应、免疫功能损伤以及癌因性疲乏。
Abstract:
Objective:To observe the efficacy of Yangyin Jiedu decoction combined with radiotherapy and chemotherapy in treating advanced nasopharyngeal carcinoma patients with syndrome of qi and yin deficiency and its effect on immune function and cancer-related fatigue.Methods:A total of 94 patients with advanced nasopharyngeal carcinoma were selected and divided into observation group and control group according to random number table method,47 cases in each group.Control group received radiotherapy and chemotherapy,observation group was given Yangyin Jiedu decoction orally on the basis of control group.Both groups were treated for 9 weeks and followed up for 6 months.Efficacy,adverse reactions,peripheral blood lymphocyte subsets and scores of cancer-induced fatigue were compared between the two groups.Results:The total effective rate was 87.23% for observation group and 65.96% for control group,and the difference was statistically significant(P<0.05).The incidence of leukopenia,neutropenia,hemoglobin reduction,gastrointestinal reaction,oral mucositis and radioactive dermatitis in the observation group were lower than those in the control group,and the difference in the incidence of oral mucositis between the two groups was statistically significant(P<0.05).After treatment,CD3+and CD4+for observation group were evidently higher as compared with control group,while CD8+was lower than that in control group(P<0.05).After 6 months of follow-up,CD3+,CD4+and CD8+in observation group were significantly improved compared with control group(P<0.05).After treatment,the scores of physical fatigue,emotional fatigue and cognitive fatigue in control group were significantly increased,and those for observation group were evidently lower than those in control group(P<0.05).Conclusion:The intervention of Yangyin Jiedu decoction on advanced nasopharyngeal carcinoma patients with qi and yin deficiency has a significant effect,which can effectively reduce the adverse reactions,immune function damage and cancer-induced fatigue caused by radiotherapy and chemotherapy.

参考文献/References:

[1] 纪佳朋,谢 波,周 娟,等.236例晚期鼻咽癌一线含铂双药化疗疗效的回顾性分析[J].临床肿瘤学杂志,2021,26(1):42-47.
[2] 杨保庆.局部晚期鼻咽癌治疗现状及进展[J].现代肿瘤医学,2021,29(2):337-341.
[3] 李 哲,刘树佳,翁玉玲,等.熟地黄多糖联合同步放疗对鼻咽癌增殖转移的影响研究[J].陕西医学杂志,2018,47(8):1003-1006.
[4] 赵 燕.人参皂苷Rg3对鼻咽癌Th1/Th2细胞因子表达情况及临床治疗效果分析[J].陕西中医,2018,39(1):101-103.
[5] 谢静怡,刘展华.周岱翰教授治疗鼻咽癌经验浅探[J].中医肿瘤学杂志,2021,3(4):109-113.
[6] 卢泰祥,潘建基,郎锦义,等.中国鼻咽癌分期2017版(2008鼻咽癌分期修订专家共识)[J].中华放射肿瘤学杂志,2017,26(10):1119-1125.
[7] 中华中医药学会.肿瘤中医诊疗指南[S].北京:中国中医药出版社,2008:1-5.
[8] 世界卫生组织.抗癌药急性及亚急性毒性反应分度标准(WHO标准)[J].癌症,1992,11(3):254.
[9] 陈克能,张力健.癌因性疲乏[J].中国肿瘤临床,1999,37(9):66-69.
[10] 康 敏.中国鼻咽癌放射治疗指南(2020版)[J].中华肿瘤防治杂志,2021,28(3):167-177.
[11] 魏俊华,邹 游,陈始明.鼻咽癌转移的分子机制研究进展[J].山东医药,2021,61(28):92-96.
[12] 凌 恺,盛 成.尼妥珠单抗联合同步放化疗治疗老年晚期鼻咽癌的临床疗效[J].中国老年学杂志,2018,38(8):1850-1852.
[13] 张 莉,华 毛.解毒利咽汤联合同期放化疗治疗局部晚期鼻咽癌的疗效观察[J].中医药导报,2021,27(9):121-124.
[14] 王 蕾,何 旭,殷常青,等.自拟解毒利咽汤联合同期放化疗对局部晚期鼻咽癌患者T淋巴细胞亚群及生活质量的影响[J].现代中西医结合杂志,2020,29(30):3374-3378.
[15] 顾亦婷,陈小宁.鼻咽癌放化疗后中医治疗思路与方法[J].中医药信息,2019,36(5):82-84.
[16] 李勇谋,蔡 美.益气养阴方联合贝优芬预防性治疗气阴两虚型鼻咽癌患者放疗后放射性皮炎30例[J].湖南中医杂志,2021,37(4):58-60.
[17] 王 松,王玲玲,阿依恒?曲库尔汗.灵芝三萜对鼻咽癌小鼠免疫功能及T细胞亚群分化的影响[J].中医药导报,2021,27(9):6-10.
[18] 谭 明,廖天志,向东华.调强适形放疗对鼻咽癌患者治疗效果及免疫功能的影响[J].癌症进展,2019,17(3):308-310.
[19] 周 帅,江锦芳,覃彦珠,等.鼻咽癌同步放化疗患者癌因性疲乏水平及其影响因素的纵向研究[J].癌症进展,2020,18(18):1858-1862,1876.
[20] 邱晓月,景永帅,郑玉光,等.北沙参多糖对免疫系统调节作用研究进展[J].中国药理学与毒理学杂志,2021,35(10):794.
[21] 吴天童,杜明月,庄 明.玉竹多糖的提取及其在食品中的应用研究进展[J].现代农业科技,2021,50(23):176-179.
[22] 孙 妍,王 静,侯 喆,等.麦冬有效部位提取及对支原体感染小鼠肺组织免疫调节作用[J].吉林中医药,2021,41(4):510-515.
[23] 周佳佳,胡 丹,林 呼.养阴解毒汤治疗鼻咽癌放疗所致口腔炎的临床研究[J].江西医药,2018,53(7):725-726,734.

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备注/Memo

备注/Memo:
基金项目:河北省廊坊市科技支撑计划项目(2021013027)
更新日期/Last Update: 2022-10-09