[1]何昊兰,鲁英娟,张小莉,等.健脾生血汤联合促红素治疗再生障碍性贫血疗效及对患者中医症候、炎症因子水平的影响[J].陕西中医,2022,(10):1411-1413,1418.[doi:DOI:10.3969/j.issn.1000-7369.2022.10.021]
　HE Haolan,LU Yingjuan,ZHANG Xiaoli,et al.Effect of Jianpi Shengxue decoction combined with erythropoietin on aplastic anemia and its effect on TCM symptoms and inflammatory factors[J].,2022,(10):1411-1413,1418.[doi:DOI:10.3969/j.issn.1000-7369.2022.10.021]
点击复制

健脾生血汤联合促红素治疗再生障碍性贫血疗效及对患者中医症候、炎症因子水平的影响

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年10期
页码:
1411-1413,1418
栏目:
临床研究
出版日期:
2022-10-05

文章信息/Info

Title:
Effect of Jianpi Shengxue decoction combined with erythropoietin on aplastic anemia and its effect on TCM symptoms and inflammatory factors
作者:
何昊兰; 鲁英娟; 张小莉; 朱 丽
(空军军医大学西京医院血液内科,陕西 西安 710032)
Author(s):
HE Haolan; LU Yingjuan; ZHANG Xiaoli; ZHU Li
(Department of Hematology,Xijing Hospital of Air Force University,Xi'an 710032,China)
关键词:
再生障碍性贫血;  促红素;  健脾生血汤;  血红蛋白;  铁蛋白;  转铁蛋白
Keywords:
Aplastic anemia;  Erythropoietin;  Jianpi Shengxue decoction;  Hemoglobin;  Ferritin;  Transferrin
分类号:
R 556.5
DOI:
DOI:10.3969/j.issn.1000-7369.2022.10.021
文献标志码:
A
摘要:
目的:分析健脾生血汤联合促红素对再生障碍性贫血的效果及对患者中医症候、炎症因子水平的影响。方法:选取104例再生障碍性贫血患者,分为对照组、观察组,各52例。对照组给予促红素治疗,观察组予健脾生血汤联合促红素治疗。比较两组患者临床疗效、中医症候、血红蛋白(Hb)、铁蛋白(SF)、转铁蛋白(TF)、炎症因子、治疗安全性。结果:观察组总有效率为90.38%,高于对照组的75.00%(P<0.05)。治疗后,观察组瘀血紫癜、心悸气短、面色萎黄、腰膝酸软症候评分均低于对照组(P<0.05)。治疗后,观察组Hb、SF、TF水平均高于对照组(P<0.05)。治疗后,观察组肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、缺氧诱导因子-2α(HIF-2α)水平均低于对照组(P<0.05)。结论:健脾生血汤结合促红素治疗再生障碍性贫血效果显著,可降低中医症候评分,提高Hb、SF、TF水平,抑制炎症反应,治疗安全性较好。
Abstract:
Objective:To analyze the effect of Jianpi Shengxue decoction combined with erythropoietin on aplastic anemia and its effect on TCM symptoms and inflammatory factors.Methods:A total of 104 patients with aplastic anemia were selected and divided into control group,observation group according to random number table method,52 cases.Control group treated with erythropoietin,observation group treated with Jianpi Shengxue decoction combined with erythropoietin.Clinical efficacy,TCM symptoms,hemoglobin(Hb),ferritin(SF),transferrin(TF),inflammatory factors and treatment safety were compared between the two group.Results:The observation group total effective rate was 90.38%,higher than that in control group 75.00%(P<0.05).The observation group scores of blood stasis and purpura,palpitations and shortness of breath,complexion and soreness of waist and knee were lower than those in control group(P<0.05).After treatment,the levels of Hb,SF and TF in the observation group were higher than that in control group(P<0.05).The observation group of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),ischemia induced factor-2α(HIF-2α)level were lower than those in the control group(P<0.05).Conclusion:Jianpi Shengxue decoction combined with erythropoietin has a significant effect on the treatment of aplastic anemia,which can reduce the score of TCM syndrome,improve the levels of Hb,SF and TF,inhibit the inflammatory response,and has a good safety.

参考文献/References:

[1] Li S,Qin M,Wu R,et al.Insensitive to PTH of CD8+T cells regulate bone marrow mesenchymal stromal cell in aplastic anemia patients[J].International Journal of Medical Sciences,2020,17(12):1665-1672.
[2] 蒋永悟.妊娠贫血患者不同孕期血常规及凝血功能变化研究[J].陕西医学杂志,2019,29(8):188-190.
[3] 熊 皓,张惠桃,陈小青,等.再生障碍性贫血患者肺炎的临床特点及相关因素分析[J].中国感染与化疗杂志,2019,19(1):27-31.
[4] 王玉洁,郭志勇,赖学莉.重组人促红细胞生成素诱发的纯红细胞再生障碍性贫血一例[J].临床肾脏病杂志,2020,20(3):85-87.
[5] Fattizzo B,Giannotta JA,Barcellini W.Mesenchymal stem cells in aplastic anemia and myelodysplastic syndromes:The “seed and soil” crosstalk[J].International Journal of Molecular Sciences,2020,21(15):5438-5443.
[6] 董昌虎,何春玲,王越月,等.再生障碍性贫血骨髓病理分型研究[J].陕西医学杂志,2019,40(6):721-722.
[7] 卢冬彦,叶小卫.健脾补血方治疗恶性肿瘤化疗后脾虚证的临床观察[J].广州中医药大学学报,2019,36(11):1721-1725.
[8] 付 蓉.再生障碍性贫血诊断与治疗中国专家共识(2017年版)[J].中华血液学杂志,2017,29(1):188-196.
[9] 谈栩铖,赵 琳,赵艺涵,等.补肾健脾活血法对重型再生障碍性贫血免疫抑制治疗后早期造血恢复的影响[J].天津中医药,2020,37(4):48-52.
[10] 丁 奇.补髓生血颗粒对慢性再生障碍性贫血负性造血调控因子的影响[J].中国中医药现代远程教育,2019,29(18):182-184.
[11] 王金环,李鹤然,郝 晶,等.补髓生血颗粒对慢性再生障碍性贫血患者骨髓VLA-4和VLA-5 mRNA表达的影响[J].广州中医药大学学报,2019,36(12):7-11.
[12] 栾 岚,刘春雨,陈楠楠.补肾生血法治疗再生障碍性贫血的作用机制研究[J].辽宁中医杂志,2020,47(3):130-133.
[13] 张琳琳,曹宇峰,吕丽丽,等.健脾补肾方治疗再生障碍性贫血疗效观察[J].河北医药,2019,41(23):3620-3622.
[14] 曹宇峰,张琳琳,吕丽丽,等.健脾补肾方对再生障碍性贫血患者免疫T细胞亚群及相关细胞因子的影响[J].河北医药,2020,42(4):508-511.
[15] 吴 萸,朱光荣.自拟补阴温阳汤治疗重型再生障碍性贫血疗效及对外周血炎症因子、T淋巴细胞亚群和microRNA的影响[J].现代中西医结合杂志,2020,29(15):1603-1607.
[16] 吕丽丽,张琳琳,曹宇峰,等.健脾补肾方对再生障碍性贫血患者CD34+和Fas表达的影响[J].河北医药,2020,28(7):1016-1019.
[17] 张兵雷,周 健,张龚莉,等.三氧化二砷联合环孢素治疗再生障碍性贫血的机制研究[J].西北药学杂志,2019,29(4):188-192.
[18] 郑 栓,万红波.健脾补肾活血泄浊方联合杂合式血液净化疗法对慢性肾衰竭患者肾功能及血清CD4+/CD8+水平的影响[J].陕西中医,2019,40(2):188-191.
[19] 马寒星,王连成.健脾生血方联合克氏针固定治疗髌骨骨折疗效及对患者VAS疼痛评分、Bostman评分的影响[J].陕西中医,2020,41(7):926-928.
[20] 孙旭奇,程业刚.健脾生血片与多糖铁复合物治疗维持性血液透析患者肾性贫血的疗效分析[J].湖北中医杂志,2020,29(3):123-126.

相似文献/References:

[1]唐洪屈,刘 娜△,刘 勇,等.从脾肾论治熟地黄在慢性再生障碍性贫血治疗中的应用*[J].陕西中医,2020,(6):780.[doi:DOI:10.3969/j.issn.10007369.2020.06.022]
[2]黄莉荣,薛 征.基于Th1/Th2失衡探讨再生障碍性贫血中西医治疗研究进展[J].陕西中医,2021,(11):1644.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.034]
　HUANG Lirong,XUE Zheng.Discussion on treatment progress of traditional Chinese and western medicine of aplastic anemia based on Th1/Th2[J].,2021,(10):1644.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.034]
[3]李 芮,刘 健,靳 楠,等.基于网络药理学探讨当归补血汤治疗再生障碍性贫血作用机制[J].陕西中医,2022,(3):384.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.028]
[4]杨 桐,田春洪,田 原,等.益血生髓颗粒对苯试剂诱导的再生障碍性贫血小鼠造血功能及T细胞亚群的影响[J].陕西中医,2022,(8):1019.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.007]
　YANG Tong,TIAN Chunhong,TIAN Yuan,et al.Effects of Yixue Shengsui granule on hematopoietic function and T cell subsets of benzene reagent-induced aplastic anermia model mice[J].,2022,(10):1019.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.007]
[5]张志辉,束永兵.益气养血方联合促红素治疗糖尿病肾病腹膜透析患者肾性贫血临床观察[J].陕西中医,2024,(5):630.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.012]
　ZHANG Zhihui,SHU Yongbing.Clinical efficacy of Yiqi Yangxue prescription combined with erythropoietin in the treatment of renal anemia in patients undergoing peritoneal dialysis for diabetic nephropathy[J].,2024,(10):630.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.012]
[6]李玎玎,何丹迪,王金环.基于“虫子学说”探讨中医药对再生障碍性贫血免疫调控的研究进展[J].陕西中医,2025,46(8):1136.[doi:DOI:10.3969/j.issn.1000-7369.2025.08.026]
　LI Dingding,HE Dandi,WANG Jinhuan.Exploring the research progress of traditional Chinese medicine on immune regulation of aplastic anemia from insect theories[J].,2025,46(10):1136.[doi:DOI:10.3969/j.issn.1000-7369.2025.08.026]
[7]袁艺心,李柯馨,叶苗青,等.基于“补肝体强肝用”思想探讨长安张氏肝病流派辨治再生障碍性贫血[J].陕西中医,2026,(1):77.[doi:DOI:10.3969/j.issn.1000-7369.2026.01.013]
　YUAN Yixin,LI Kexin,YE Miaoqing,et al.Discussion on the treatment of aplastic anaemia by Chang’an ZHANG’s liver disease school based on the idea of “nourishing the liver’s substance and strengthening the liver’s function”[J].,2026,(10):77.[doi:DOI:10.3969/j.issn.1000-7369.2026.01.013]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82100218)
更新日期/Last Update: 2022-10-09