[1]谭 锴,曾普华,郜文辉,等.基于癌毒-态靶理论探讨生物碱类天然药物配伍治疗癌痛[J].陕西中医,2022,(11):1585-1588.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.022]
　TAN Kai,ZENG Puhua,GAO Wenhui,et al.Exploring the compatibility of alkaloids in natural medicines in the treatment of cancer pain based on cancer toxin-state and target theory[J].,2022,(11):1585-1588.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.022]
点击复制

基于癌毒-态靶理论探讨生物碱类天然药物配伍治疗癌痛
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年11期
页码:
1585-1588
栏目:
学术探讨
出版日期:
2022-11-05

文章信息/Info

Title:
Exploring the compatibility of alkaloids in natural medicines in the treatment of cancer pain based on cancer toxin-state and target theory
作者:
谭 锴1; 曾普华2; 郜文辉1; 张长慧1
(1.湖南中医药大学,湖南 长沙 410208; 2.湖南省中医药研究院附属医院,湖南 长沙 410006)
Author(s):
TAN Kai; ZENG Puhua; GAO Wenhui; ZHANG Changhui
(Hunan University of Traditional Chinese Medicine,Changsha 410208,China)
关键词:
癌痛;  癌毒;  态靶;  生物碱;  配伍;  镇痛制剂
Keywords:
Cancer pain;  Cancer toxin;  State and target;  Alkaloids;  Compatibility;  Analgesic preparations
分类号:
R 730
DOI:
DOI:10.3969/j.issn.1000-7369.2022.11.022
文献标志码:
A
摘要:
癌痛是影响癌症晚期患者生活质量的主要原因之一。癌痛发病机制极其复杂,西医学治疗癌痛疗效欠佳。现通过“癌毒学说”确定癌痛的病因病机和治疗原则; 依靠“态靶理论”全方面把握癌痛全过程,精准制定靶方靶药; 挖掘具有安全性、疗效性和多样性的生物碱类天然药物的镇痛作用; 探讨生物碱类天然药物在中医药内治、外治法中如何配伍成镇痛制剂,同时查阅药理研究、临床试验等保证其科学性和有效性,凸显中药药效显著、无成瘾性、不良反应少及资源丰富等天然优势,从而更好地应用中医药内外兼治、提高癌痛缓解率、改善癌痛患者的整体生活质量,使其成为癌痛综合治疗的重要手段之一。
Abstract:
Cancer pain is one of the main reasons affecting the quality of life of patients with advanced cancer.The pathogenesis of cancer pain is extremely complex,and western medicine is not effective in treating cancer pain.The article identifies the etiology and pathogenesis and treatment principles of cancer pain through the “cancer toxin theory”,relies on the “state and target theory” to grasp the whole process of cancer pain and precisely formulate target prescriptions and target herbs,explores the analgesic effects of alkaloids in natural medicines with safety,efficacy and diversity.Finally,discussion on how alkaloids in natural medicines are compatible with analgesic preparations in the internal and external treatment of traditional Chinese medicine.At the same time,pharmacological research,clinical trials will be consulted to ensure the scientificity and effectiveness of the products,highlighting the natural advantages of traditional Chinese medicine such as significant efficacy,non-addictive,few adverse reactions and abundant resources,so as to better apply both internal and external treatment of Chinese medicine,increase the remission rate of cancer pain and improve the overall quality of life of cancer pain patients,making it one of the important means of comprehensive treatment of cancer pain.

参考文献/References:

[1] 中华人民共和国国家卫生健康委员会.癌症疼痛诊疗规范(2018年版)[J].临床肿瘤学杂志,2018,23(10):937-944.
[2] 程海波,王俊壹,李 柳.癌毒病机分类及其在肿瘤临床治疗中的应用[J].中医杂志,2019,60(2):119-122.
[3] 肖雅瑜,曾普华,郜文辉,等.曾普华教授辨治胰腺癌特色探析[J].陕西中医,2020,41(5):667-669,681.
[4] 仝小林.态靶医学——中医未来发展之路[J].中国中西医结合杂志,2021,41(1):16-18.
[5] 王玲燕,夏桂阳,夏 欢,等.天然生物碱类镇痛成分的研究进展[J].中国中药杂志,2020,45(24):5829-5839.
[6] 张新庄,柯志鹏,李 娜,等.从网络角度研究元胡止痛胶囊治疗头痛与痛经的分子作用机制[J].中国新药杂志,2016,25(20):2323-2330.
[7] 魏 黎,肖 红,谢元明,等.奥施康定联合复方苦参注射液治疗骨转移癌痛临床疗效以及对患者生活质量、癌痛情况影响研究[J].陕西医学杂志,2018,47(12):1626-1628.
[8] 王 薇,李 杰,刘 航,等.草乌甲素片治疗轻中度癌痛多中心、随机对照、非劣效性研究[J].中国疼痛医学杂志,2021,27(3):188-195.
[9] Ameri A.The effects of Aconitum alkaloids on the central nervous system[J].Prog Neurobiol,1998,56(2):211-235.
[10] Yu G,Qian L,Yu J,et al.Brucine alleviates neuropathic pain in mice via reducing the current of the sodium channel[J].J Ethnopharmacol,2019,233:56-63.
[11] Yin W,Wang TS,Yin FZ,et al.Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of strychnos nux-vomica[J].J Ethnopharmacol,2003,88(2):205-214.
[12] 邹方友,周 莉,熊宜军.复方夏天无片治疗轻度癌痛的临床观察[J].中国现代应用药学,2011,28(3):268-270.
[13] 吴雪松,许 浚,张喜民,等.元胡止痛方的化学成分及药理作用研究进展[J].中草药,2015,46(7):1081-1095.
[14] Liu YY,Wang TX,Zhou JC,et al.Dopamine D1and D2receptors mediate analgesic and hypnotic effects of l-tetrahydropalmatine in a mouse neuropathic pain model[J].Psychopharmacology,2019,236(11):3169-3182.
[15] 张 明.复方马钱子胶囊治疗癌痛的疗效观察[J].上海中医药大学学报,2001,15(2):31-32.
[16] 高建清,雷艳容,陈红蓓.中药外敷痛点及腧穴配合针刺对晚期肺癌患者癌痛程度、睡眠质量的影响[J].陕西中医,2020,41(7):972-975,979.
[17] 喻 明,王华伟,王文萍,等.中药止痛贴联合吗啡治疗中重度癌痛的多中心临床研究[J].中国新药与临床杂志,2015,34(8):617-621.
[18] Lee JY,Yoon SY,Won J,et al.Sinomenine produces peripheral analgesic effects via inhibition of voltage-gated sodium currents[J].Neuroscience,2017,358:28-36.
[19] Zhu Q,Sun Y,Zhu J,et al.Antinociceptive effects of sinomenine in a rat model of neuropathic pain[J].Sci Rep,2014,4:7270.
[20] Yin LL,Zhu XZ.The involvement of central cholinergic system in matrine-induced antinociception in mice[J].Pharmacol Biochem Behav,2005,80(3):419-425.
[21] Liu HY,Li YX,Hao YJ,et al.Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice[J].CNS Neurosci Ther,2012,18(12):1030-1032.
[22] 安国松,张润宁,寇久社,等.盐酸羟考酮缓释片联合射频热凝对骨转移癌痛患者镇痛效果、睡眠及生活质量的影响[J].陕西医学杂志,2020,49(12):1645-1647.
[23] 黄凤仙,靳荣辉,高 晖,等.两种不同放疗方案联合热疗治疗骨转移瘤临床研究[J].陕西医学杂志,2021,50(5):550-554.

相似文献/References:

[1]陈 军,乔海法,李 静,等.艾灸背俞穴联合羟考酮缓释片干预癌痛临床研究*[J].陕西中医,2020,(1):105.
　CHEN Jun,QIAO Haifa,LI Jing,et al.The clinic research of BackShu point moxibustion plus oral oxycodone in cancer pain[J].,2020,(11):105.
[2]江 东,徐长亮,沈卫星,等.参白解毒方对溃疡性结肠炎肠黏膜上皮细胞保护作用机制研究[J].陕西中医,2022,(1):23.[doi:DOI:10.3969/j.issn.1000-7369.2022.01.005]
　JIANG Dong,XU Changliang,SHEN Weixing,et al.Explore protective mechanism of Shenbai Jiedu decoction on colon epithelial cells of ulcerative colitis[J].,2022,(11):23.[doi:DOI:10.3969/j.issn.1000-7369.2022.01.005]
[3]简小兰,蒋益兰,蒋盛昶.蒋益兰教授治疗恶性肿瘤骨转移经验[J].陕西中医,2022,(5):620.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.018]
　JIAN Xiaolan,JIANG Yilan,JIANG Shengchang.Experiences from Professor JIANG Yilan in treating bone metastasis of malignant tumour[J].,2022,(11):620.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.018]
[4]邢 莹,滕钰浩,王瑞平.王瑞平辨治胰腺癌经验探讨[J].陕西中医,2023,(2):241.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.024]
　XING Ying,TENG Yuhao,WANG Ruiping.Discussion on the experience of WANG Ruiping in syndrome differentiation and treatment of pancreatic cancer[J].,2023,(11):241.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.024]
[5]雷 勇,杨 永,王笑民.名中医王笑民基于消燚祛瘀法治疗大肠癌便血经验[J].陕西中医,2023,(7):936.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.026]
[6]宁永波,王雅兴,陈香颖,等.名中医王瑞平“期证相合”理论在肺癌术后研究肿瘤微环境经验[J].陕西中医,2023,(10):1448.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.026]
　NING Yongbo,WANG Yaxing,CHEN Xiangying,et al.Wang Ruiping's theory of “phase correspondence” in postoperative lung cancer patients[J].,2023,(11):1448.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.026]
[7]吕 晶,赵晓平,范小璇,等.赵晓平基于“虚瘀毒损”治疗脑胶质瘤术后复发经验[J].陕西中医,2024,(7):955.[doi:DOI:10.3969/j.issn.1000-7369.2024.07.021]
　LYU Jing,ZHAO Xiaoping,FAN Xiaoxuan,et al.ZHAO Xiaoping's experience in treatment of glioma recurrence after surgery using theory of deficiency stasis and toxic damage[J].,2024,(11):955.[doi:DOI:10.3969/j.issn.1000-7369.2024.07.021]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82074425); 全国青年岐黄学者人才项目[国中医药人教函(2020)7号]; 湖南省重点研发计划项目(2021SK2006); 湖南省自然科学基金资助项目(2021JJ30417); 抗肿瘤中药创制技术湖南省工程研究中心项目[长发改高技(2016)886号]
更新日期/Last Update: 2022-11-09