[1]仪 凡,王晓旭,赵子慧,等.从肝论治寻常型银屑病伴焦虑抑郁Meta分析[J].陕西中医,2022,(11):1632-1637.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.034]
　YI Fan,WANG Xiaoxu,ZHAO Zihui,et al.Meta-analysis of resolving superficies method in the treatment of psoriasis vulgaris[J].,2022,(11):1632-1637.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.034]
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从肝论治寻常型银屑病伴焦虑抑郁Meta分析
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年11期
页码:
1632-1637
栏目:
Meta分析
出版日期:
2022-11-05

文章信息/Info

Title:
Meta-analysis of resolving superficies method in the treatment of psoriasis vulgaris
作者:
仪 凡1; 2; 王晓旭1; 赵子慧1; 2; 刘博文2; 张广中1
(1.首都医科大学附属北京中医医院,北京 100010; 2.北京中医药大学,北京 100020)
Author(s):
YI Fan; WANG Xiaoxu; ZHAO Zihui; LIU Bowen; ZHANG Guangzhong
(Beijing Hospital of Traditional Chinese Medicine,Affiliated to Capital Medical University,Beijing 100010,China)
关键词:
寻常型银屑病;  从肝论治;  焦虑抑郁;  Meta分析;  随机对照试验
Keywords:
Psoriasis vulgaris;  Treatment from the liver;  Anxiety and depression;  Meta-analysis;  Randomized controlled trial
分类号:
R 758.63
DOI:
DOI:10.3969/j.issn.1000-7369.2022.11.034
文献标志码:
A
摘要:
目的:系统评价从肝论治寻常型银屑病伴焦虑抑郁的效果与安全性。方法:搜集建库以来针对寻常型银屑病从肝论治的随机对照研究(RCT),由2名研究者独立筛选文献、提取资料和评价偏倚风险,采用 Rev Man 5.4 软件进行合并分析。主要分析指标为总有效率、银屑病面积与严重性指数(PASI评分)、SAS评分、SDS评分、HAMD评分、不良反应发生率等。结果:共纳入8个RCT,共计738例患者。Meta分析结果显示从肝论治较其他治疗方式在提高临床总有效率[RR=1.23,95%CI(1.12,1.35),P<0.00001]、降低PASI评分[MD=-1.30,95%CI(-1.65,-0.95),P<0.00001]、减低SAS、SDS、HAMD评分[SAS:MD=-7.36,95%CI(-12.12,-2.61),P=0.002; SDS:MD=-7.67,95%CI(-13.26,-2.08),P=0.007; HAMD:MD=-4.85,95%CI(-6.05,-3.65),P<0.00001]、降低不良反应发生率[RR=0.33,95%CI(0.16,0.70),P=0.004]方面差异显著,具有统计学意义。结论:从肝论治寻常型银屑病伴焦虑抑郁有较好的临床疗效与安全性。但本研究纳入文献数据质量偏低,样本量不足,今后需开展更多高质量、大样本研究,对从肝论治寻常型银屑病伴焦虑抑郁的疗效优势进一步验证。
Abstract:
Objective:To systematically evaluate the efficacy and safety of treating psoriasis vulgaris with anxiety and depression from liver.Methods:Randomized controlled trials(RCTs)on the treatment of psoriasis vulgaris from liver were collected.Two reviewers independently screened literature,extracted data and assessed risk of bias.Rev Man 5.4 software was used for Meta-analysis.The main analysis indexes were:total effective rate,psoriasis area and severity index(PASI score),Zung Self-Rating Anxiety Scale(SAS score),Self-rating Depression Scale(SDS score),Hamilton Depression Scale(HAMD score),incidence of adverse reactions,etc.Results:A total of 8 RCTs involving 738 patients were included.The results of Meta-analysis showed that the application of treatment from the liver compared with other treatment methods improved the clinical effective rate [RR=1.23,95%CI(1.12,1.35),P<0.00001],and decreased the PASI score [MD=-1.30,95%CI(-1.65,-0.95),P<0.00001],reduced SAS,SDS,HAMD score [SAS:MD=-7.36,95%CI(-12.12,-2.61),P=0.002; SDS:MD=-7.67,95%CI(-13.26,-2.08),P=0.007; HAMD:MD=-4.85,95%CI(-6.05,-3.65),P<0.00001],reduced incidence of adverse reactions [RR=0.33,95%CI(0.16,0.70),P=0.004],the difference was statistically significant.Concludion:There is a good clinical efficacy and safety from the anxiety depression from the constant type of psoriasis from the liver theory.However,this study is included in the low quality of literature,the amount of sample is insufficient.In the future,more high-quality and large-sample studies are needed to further scientifically verify the therapeutic advantages of treating psoriasis vulgaris with anxiety and depression from the liver.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81974572)
更新日期/Last Update: 2022-11-09