[1]林瑞芳,俞赟丰,阳凌峰,等.基于肠道菌群探讨中医药治疗功能性消化不良研究进展[J].陕西中医,2022,(11):1647-1650.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.037]
　LIN Ruifang,YU Yunfeng,YANG Lingfeng,et al.Research progress on treatment of functional dyspepsia with traditional Chinese medicine based on intestinal flora[J].,2022,(11):1647-1650.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.037]
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基于肠道菌群探讨中医药治疗功能性消化不良研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年11期
页码:
1647-1650
栏目:
综 述
出版日期:
2022-11-05

文章信息/Info

Title:
Research progress on treatment of functional dyspepsia with traditional Chinese medicine based on intestinal flora
作者:
林瑞芳; 俞赟丰; 阳凌峰; 喻 斌; 徐 寅
(湖南中医药大学第一附属医院,湖南 长沙 410007)
Author(s):
LIN Ruifang; YU Yunfeng; YANG Lingfeng; YU Bin; XU Yin
(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)
关键词:
功能性消化不良;  肠道菌群;  有效成分;  中药复方;  四君子汤
Keywords:
Functional dyspepsia;  Intestinal flora;  Effective ingredients;  Chinese herbal formulae;  Sijunzi decoction
分类号:
R 57
DOI:
DOI:10.3969/j.issn.1000-7369.2022.11.037
文献标志码:
A
摘要:
肠道菌群与功能性消化不良(FD)的发生发展密切相关。在生理状态下,厚壁菌门和拟杆菌门是人类肠道微生物群的优势菌群(>98%),两者的比值是反映肠道微生物群紊乱的重要指标。在病理状态下,紊乱的肠道菌群通过影响胃肠动力、破坏胃肠道屏障功能和免疫功能、紊乱脑-肠轴功能及影响药物吸收代谢等机制参与FD的发生发展。研究表明,中医药能够通过扶植益生菌生长和抑制有害菌增殖来逆转肠道菌群失调,从而减轻FD患者的临床症状。白术、炙甘草、枳实、神曲等中药,以及四君子汤、参苓白术散、逍遥散、半夏泻心汤、焦三仙、调中健脾汤、胃祺饮等复方均能够通过调节肠道菌群起到治疗FD的作用,具有一定的应用前景。
Abstract:
The intestinal flora is closely related to the occurrence and development of functional dyspepsia(FD).In physiological state,Firmicutes and Bacteroidetes are the dominant flora(>98%)of human gut microbiota,and their ratio is an important index to reflect the disturbance of gut microbiota.Under pathological conditions,disturbed intestinal flora participates in the occurrence and development of FD by affecting gastrointestinal motility,disrupting gastrointestinal barrier function and immune function,disrupting brain-gut axis function and affecting drug absorption and metabolism.Studies have shown that traditional Chinese medicine can reverse the imbalance of intestinal flora by supporting the growth of probiotics and inhibiting the proliferation of harmful bacteria,thereby alleviating the clinical symptoms of FD patients.Both traditional Chinese medicines such as Baizhu,Zhigancao,Zhishi,Shenqu,and Chinese herbal formulae such as Sijunzi decoction,Shenling Baizhu powder,Xiaoyao powder,Banxia Xiexin decoction,Jiaosanxian,Tiaozhong Jianpi decoction and Weiqi Yin can play a role in the treatment of FD by regulating intestinal flora,which has a certain application prospect.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81904176); 全国名老中医药专家传承工作室建设项目[国中医药人教函(2022)75号]; 湖南省教育厅科学研究项目(21B0389)
更新日期/Last Update: 2022-11-09