[1]杨淑彬,李 婷,李晓妮,等.不同中药结肠透析模式对慢性肾脏病患者胃肠道症状和营养状态的影响[J].陕西中医,2022,(12):1698-1701.[doi:DOI:10.3969/j.issn.1000-7369.2022.12.010]
　YANG Shubin,LI Ting,LI Xiaoni,et al.Effects of different colon dialysis modes of traditional Chinese medicine on gastrointestinal symptoms and nutritional status in patients with chronic kidney disease[J].,2022,(12):1698-1701.[doi:DOI:10.3969/j.issn.1000-7369.2022.12.010]
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不同中药结肠透析模式对慢性肾脏病患者胃肠道症状和营养状态的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年12期
页码:
1698-1701
栏目:
临床研究
出版日期:
2022-12-20

文章信息/Info

Title:
Effects of different colon dialysis modes of traditional Chinese medicine on gastrointestinal symptoms and nutritional status in patients with chronic kidney disease
作者:
杨淑彬1; 李 婷1; 李晓妮1; 边 静2; 杨永红1
(1.陕西省中医医院,陕西 西安 710003; 2.解放军联勤保障部队第九八七医院,陕西 宝鸡 721004)
Author(s):
YANG Shubin;  LI Ting;  LI Xiaoni;  BIAN Jing;  YANG Yonghong
(Shaanxi Provincial Hospital of Chinese Medicine, Xi'an 710003,China)
关键词:
慢性肾脏病;  自拟湿热方;  结肠透析;  中药高位保留灌肠;  血肌酐;  尿素氮
Keywords:
Chronic kidney disease;  Self preparation of damp heat;  Colon dialysis;  High retention enema with traditional Chinese medicine;  Serum creatinine;  Blood urea nitrogen
分类号:
R 692
DOI:
DOI:10.3969/j.issn.1000-7369.2022.12.010
文献标志码:
A
摘要:
目的:探讨不同中药结肠透析模式对慢性肾脏病患者胃肠道症状和营养状态的影响和效果。方法:将慢性肾脏病患者90例按随机数字表法分为对照组和观察组各45例,对照组采用中药(医院自煎自拟湿热方)保留灌肠治疗,观察组采用结肠透析序贯中药(医院自煎自拟湿热方)高位保留灌肠治疗,所有研究对象均治疗2周,隔天治疗1次。疗程结束后,比较两组血肌酐(Scr)、尿素氮(BUN)、主观综合性营养评估(SGA)、肠道功能评价及临床治疗效果。结果:治疗后,观察组Scr、BUN下降明显,主观综合性营养评估、肠道功能评价及临床疗效均优于对照组。结论:结肠透析序贯中药高位保留灌肠治疗可改善患者营养状态和胃肠道症状,具有较好的临床疗效。
Abstract:
Objective:To investigate the effects of different colon dialysis modes of traditional Chinese medicine on gastrointestinal symptoms and nutritional status in patients with chronic kidney disease.Methods:90 patients with chronic kidney disease were randomly divided into the control group and the observation group with 45 cases each.The control group were treated with retention enema of traditional Chinese medicine(self decoction and self preparation of damp heat in the hospital), and the observation group were treated with high retention enema of colon dialysis sequential traditional Chinese medicine(self decoction and self preparation of damp heat in the hospital).All subjects were treated for 2 weeks and once every other day.At the end of the course of treatment, the two groups were compared in serum creatinine(SCR),blood urea nitrogen(BUN), subjective comprehensive nutritional assessment(SGA), intestinal function evaluation and clinical treatment effect.Results:After treatment, the levels of SCR and BUN in the observation group decreased significantly, and the subjective comprehensive nutritional evaluation, intestinal function evaluation and clinical efficacy were better than those in the control group.Conclusion:Colon dialysis sequential high retention enema with traditional Chinese medicine can improve the nutritional status and gastrointestinal symptoms of patients, with better clinical efficacy.

参考文献/References:

[1] 梁 衍,闫晓辉.高位结肠透析联合肾康栓保留灌肠治疗慢性肾脏病的疗效观察[J].临床医学研究与实践,2016,15(1):18-19.
[2] Dersky AS,Mclaugh JR,Baker JP,et al.What is subjective global assessment of nutritional status[J].Parenter Enterol Nutr,1987,11(1):8-13.
[3] 中国行为医学科学编辑委员会.行为医学量表手册[M].北京:中华医学电子音像出版社,2005:223-224.
[4] 国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:163-168.
[5] Louis E,Tack J,Vandenhoven G,et al.Evaluation of the GERD impact scale an international validated patient questionnaire in daily practice results of the alegria study[J].Acta Gastroenterol Belg,2009,72(1):3-8.
[6] Urganci N,Ozcelik G,Kalyoncu D,et al.Serum gastrin levels and gastroduodenal lesions in children with chronic renal failure on continuous ambulatory peritoneal dialysis:A single-center experience[J].Eur J Gastroenterol Hepatol,2012,24(10):924-928.
[7] Bacci M,Russo F,Carvalho G,et al.Endoscopic alterations in acohort of hemodialysis patients:A cross-sectional study[J].Int J Gen Med,2014,16(7):459-461.
[8] Borazan A,Cavdar Z,Saglam F.The effect of renal replacementtherapies on serum gastrointestinal system hormones[J].Ren Fail,2007,29(8): 1019-1023.
[9] 张 静,郭立华,姜 琦,等.胃肠肽激素在慢性肾功能衰竭患者行血液透析后的变化影响[J].现代消化及介入诊疗,2016,21(1):135-137.
[10] Dejardin A,Robert A,Goffin E.Intraperitoneal pressure in PD patients:Relationship tointraperitoneal volume body size and PD-related complications[J].Nephrol Dial Transplant,2007,22(5): 1437-1444.
[11] Van V,Schoonjans RS,Struijk DG,et al.Influence of dialysate on gastric emptying time in peritoneal dialysis patients[J].Perit Dial Int,2002,22(1): 32-38.
[12] Santos PR,Monteiro DL,De PH,et al.Volaemic status and dyspepsia in end-stage renal disease patients[J].Nephrology(Carlton),2015,20(8):519-522.
[13] Salles LD,Santos PR,Santos AA,et al.Dyspepsiaand gastric emptying in end-stage renal disease patients on hemodi-alysis[J].BMC Nephrol,2013,14(14):275-279.
[14] 魏金花,张翠芹.辨证分型应用中药结肠透析治疗慢性肾衰竭早中期32例疗效观察[J].中国中西医结合肾病杂志,2014,15(3):228.
[15] 段昱芳,张海滨.结肠透析治疗慢性肾脏病2-4期65例患者的疗效观察[J].中国中西医结合肾病杂志,2015,16(5): 444-445.
[16] 高辰馨,张勉之.补肾活血法配合结肠透析治疗早中期慢性肾衰竭的短期临床观察[J].中华中医药杂志,2014,29(6):2063-2065.
[17] 海广范,詹合琴,许 华,等. nmhaFGF对肾脏缺血再灌注损伤大鼠不同时间SOD、MDA、BUN、Cr和尿蛋白含量的影响[J].陕西医学杂志,2009,38(7):774-777.
[18] 马 丽,何 帆,杨文君. 联机和高通量血液透析单独与贯序应用对于终末期肾病患者透析充分性和生活质量的影响[J].重庆医学,2019,48(8):1354-1358,1362.
[19] 李柱宏,李开龙,杨聚荣,等. 血液透析联合血液滤过清除尿毒症患者血清成纤维细胞生长因子23的效果观察[J].中华临床医师杂志:电子版,2012,6(4):897-900.
[20] 林 钐.不同方式中药结肠透析在慢性肾脏病的研究进展[J].中国中西医结合肾病杂志,2019,20(1):80-81.
[21] 周 刊,吕冬宁,曾海飞.中药结肠透析治疗慢性肾衰竭临床应用进展[J].广西中医药大学学报,2019,22(2):63-65.
[22] 杨淑彬,陈婉丽.中药结肠透析改良法治疗慢性肾衰竭疗效观察[J].陕西中医,2015,36(12):1616-1617.
[23] 段连香,刘子洋,陈 杰,等. 叶氏降酐合剂结肠透析治疗湿热蕴结型慢性肾脏病4期患者的短期疗效观察[J].中国中西医结合肾病杂志,2022,23(5):435-437.
[24] 毛东东,熊 飞,周文祥,等. 参芪肾衰合剂联合结肠透析对慢性肾脏病4期(脾肾气虚证)患者的临床疗效观察[J].临床肾脏病杂志,2022,22(6):465-470.
[25] 晏慧民,童 薇,邱国萍. 中药结肠透析联合尿毒清颗粒对慢性肾脏病3-5期患者疗效及肾功能指标的影响[J].中国当代医药,2022,29(19):105-108.

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备注/Memo

备注/Memo:
基金项目:陕西省中医药管理局科研课题(YSPT004)
更新日期/Last Update: 2022-12-09