[1]邢 莹,滕钰浩,王瑞平.王瑞平辨治胰腺癌经验探讨[J].陕西中医,2023,(2):241-244.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.024]
　XING Ying,TENG Yuhao,WANG Ruiping.Discussion on the experience of WANG Ruiping in syndrome differentiation and treatment of pancreatic cancer[J].,2023,(2):241-244.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.024]
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王瑞平辨治胰腺癌经验探讨
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年2期
页码:
241-244
栏目:
名中医经验
出版日期:
2023-02-05

文章信息/Info

Title:
Discussion on the experience of WANG Ruiping in syndrome differentiation and treatment of pancreatic cancer
作者:
邢 莹; 滕钰浩; 王瑞平
(南京中医药大学附属医院,江苏 南京 210029)
Author(s):
XING Ying; TENG Yuhao; WANG Ruiping
(The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)
关键词:
胰腺癌;  脾虚肝郁;  用药特色;  癌毒;  健脾
Keywords:
Pancreatic cancer;  Spleen deficiency and liver depression;  Characteristic use of traditional Chinese medicine;  Poison of cancer;  Invigorating the spleen
分类号:
R 735.9
DOI:
DOI:10.3969/j.issn.1000-7369.2023.02.024
文献标志码:
A
摘要:
胰腺癌是难治性消化系恶性肿瘤,具有早期确诊率低、恶性程度高的特点,中医药在胰腺癌综合治疗中处于重要地位。王瑞平老师从多年临床经验中总结出胰腺癌“脾虚肝郁”的核心病机,治疗上强调以健脾为第一要义,以肝脾同调为基本治则,并针对关键病理因素如湿、痰、瘀、毒建立化湿泄浊、化痰散结、化瘀消癥、抗癌解毒等具体治法。同时王老师认为辨治胰腺癌须在分期论治的基础上动态辨明患者整体正邪盛衰,将辨病论治与辨证论治有机结合,融入“孟河医派”学术思想,形成了个体诊疗、动态调治、用药醇正、和缓图之的诊疗特色,临床上取得良好疗效。现从病因病机、治法治则,处方特色等方面总结梳理了王瑞平教授临床治疗胰腺癌的经验,以期指导临床实践,为临床上治疗该病开拓新思路。
Abstract:
Pancreatic cancer is a refractory digestive malignant tumor,with the characteristics of low early diagnosis rate and high degree of malignancy.Traditional Chinese medicine occupies an important position in the comprehensive treatment of pancreatic cancer.WANG Ruiping summed up the core pathogenesis of pancreatic cancer “spleen deficiency and liver stagnation” from many years of clinical experience.In terms of treatment,it is emphasized that invigorating the spleen is the first principle,and harmonizing the liver and spleen is the basic treatment principle.In view of the key pathological factors such as dampness,phlegm,blood stasis,and poison,specific treatment methods are established,such as dissipating dampness and dispelling turbidity,dissolving phlegm and resolving messes,removing stasis and eliminating abdominal mass,anti-cancer and detoxification method.Meanwhile,WANG Ruiping believed that the differential treatment of pancreatic cancer should dynamically identify the exuberance and debilitation of healthy qi and the pathogenic qi on the basis of treatment by stages.She organically combined treatment based on disease differentiation and syndrome differentiation,integrated into the academic thought of “Menghe medical school”,and formed the characteristics of individual diagnosis and treatment,dynamic treatment,drug mellow,and gentle treatment.It has achieved good clinical effects.This paper summarized WANG Ruiping's experience in the treatment of pancreatic cancer from the etiology and pathogenesis,therapeutic method and principles,and prescription characteristics to guide the clinical practice and open up new ideas for the clinical treatment of the disease.

参考文献/References:

[1] 宋亚邛,胡海燕.VEGF、TGF-β1、CA199、CA242 和DKK1联合检测对早期胰腺癌临床诊断价值研究[J].陕西医学杂志,2020,49(2):237-240.
[2] Siegel RL,Miller KD,Jemal A.Cancer statistics,2020[J].CA: A Cancer Journal For Clinicians,2020,70(1):7-30.
[3] 王延磊,王政华.CT引导下125I粒子植入联合吉西他滨、卡培他滨治疗局部进展期胰腺癌临床疗效观察[J].陕西医学杂志,2020,49(12):1604-1607.
[4] 庞 博,姜晓晨,刘福栋,等.胰腺癌中医药防治研究述评[J].北京中医药,2020,39(8):795-799.
[5] 蒋 里,简 婕,王世东,等.胰腺疾病中医病名考辨[J].北京中医药,2020,39(8):777-781.
[6] 黄 蓉,张培彤,缪 锐.基于证候分层诊断模式的223例胰腺癌患者中医证型分布特点回顾性分析[J].中医杂志,2022,63(6):551-556.
[7] 李 奕,张曦元,庞 博,等.胰腺癌从“调气解毒”立论的中医药治疗策略与实践[J].世界中医药,2022,17(11):1502-1505,1510.
[8] 程海波,周仲瑛.癌毒病机科学内涵的现代诠释[J].南京中医药大学学报,2021,37(5):637-641.
[9] 魏小曼,李 柳,王俊壹,等.癌毒病机理论辨治胰腺癌探讨[J].中华中医药杂志,2022,37(4):2062-2065.
[10] 谭 艳,陈 聪,周 聪,等.历代医家对黄疸病的认识[J].中国中医急症,2021,30(1):149-151,155.
[11] 徐楚韵,黄建波,张光霁.基于痰毒理论探讨肿瘤发病规律及其病证特点[J].中华中医药杂志,2021,36(10):5801-5803.
[12] 刘包欣子,金志超,邵 杰,等.王瑞平教授运用解毒散结对药治疗恶性肿瘤经验[J].陕西中医,2021,42(11):1601-1606,1634.
[13] 张光霁,徐楚韵.基于中医病机“瘀毒互结”致病理论的肿瘤“瘀毒同治”特色理论及抗肿瘤创新药物研究[J].浙江中医药大学学报,2019,43(10):1052-1057.
[14] 程海波,李 柳,孙东东,等.抗癌解毒法的建立与应用[J].中医杂志,2022,63(15):1420- 1426.
[15] Nawaz A,Jamal A,Arif A,et al.In vitro cytotoxic potential of solanum nigrum against human cancer cell lines[J].Saudi Journal of Biological Sciences,2021,28(8):4786-4792.
[16] Hu WL,Wu CC,Yuan CC,et al.Ethanol extracted from radix of actinidia chinensis inhibits human colon tumor through inhibiting notch-signaling pathway[J].Journal of Cancer,2021,12(3):622-629.
[17] 袁文婷,肖茂良,肖 锋.半枝莲提取物通过PI3K-Akt信号通路抑制胰腺癌模型大鼠肿瘤生长的机制研究[J].陕西中医,2021,42(12):1676-1679.
[18] 杨宇飞.基于“损者益之”的序贯健脾补肾法协同化疗方案刍议[J].中医杂志,2021,62(2):125-129.
[19] 胡博婷,方文岩.浅谈六腑以通为用在胰腺癌中的应用[J].中国中医药现代远程教育,2022,20(5):72-75.
[20] 谭 滢,朱潇雨,李 杰.基于“诸逆冲上,皆属于火”探讨肿瘤相关性呃逆的病因病机与治法[J].中医杂志,2021,62(24):2153-2156.

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备注/Memo

备注/Memo:
基金项目:江苏省自然科学基金资助青年项目(BK20181097); 江苏省研究生科研与实践创新计划项目(SJCX22-0722)
更新日期/Last Update: 2023-02-08